Thalamic shape and volume abnormalities in female patients with panic disorder

Asami, Takeshi; Yoshida, Haruhisa; Takaishi, Masao; Nakamura, Ryôkô; Yoshimi, Asuka; Whitford, Thomas J.; Hirayasu, Yoshio

doi:10.1371/journal.pone.0208152

Cited by 23 publications

(14 citation statements)

References 54 publications

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“…Studies have indicated that the VA has anatomical and functional connections with the rest of the thalamic nuclei and regions within the frontolimbic circuit, namely the basal ganglia and prefrontal cortices ( McFarland and Haber, 2002 ; Grodd et al. , 2020 ), and is thus thought to be an important center for executive and motor functioning as well as reward and emotion processing ( Xiao and Barbas, 2002 , 2004 ; Child and Benarroch, 2013 ; Asami et al. , 2018 ; Wolff and Vann, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Shared and unique neural circuitry underlying temporally unpredictable threat and reward processing

Radoman

Lieberman

Jimmy

et al. 2021

Social Cognitive and Affective Neuroscience

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Temporally unpredictable stimuli influence behavior across species, as previously demonstrated for sequences of simple threats and rewards with fixed or variable onset. Neuroimaging studies have identified a specific frontolimbic circuit that may become engaged during the anticipation of temporally unpredictable threat (U-threat). However, the neural mechanisms underlying processing of temporally unpredictable reward (U-reward) are incompletely understood. It is also unclear whether these processes are mediated by overlapping or distinct neural systems. These knowledge gaps are noteworthy given that disruptions within these neural systems may lead to maladaptive response to uncertainty. Here, using functional magnetic resonance imaging data from a sample of 159 young adults, we showed that anticipation of both U-threat and U-reward elicited activation in the right anterior insula, right ventral anterior nucleus of the thalamus and right inferior frontal gyrus. U-threat also activated the right posterior insula and dorsal anterior cingulate cortex, relative to U-reward. In contrast, U-reward elicited activation in the right fusiform and left middle occipital gyrus, relative to U-threat. Although there is some overlap in the neural circuitry underlying anticipation of U-threat and U-reward, these processes appear to be largely mediated by distinct circuits. Future studies are needed to corroborate and extend these preliminary findings.

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Section: Discussionmentioning

confidence: 99%

Shared and unique neural circuitry underlying temporally unpredictable threat and reward processing

Radoman

Lieberman

Jimmy

et al. 2021

Social Cognitive and Affective Neuroscience

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“…The ventral thalamic changes also corresponded with neuropsychiatric symptoms. The involvement of the ventral thalamus in neuropsychiatric symptoms has been found in anxiety, panic disorders, and schizophrenia [38,39]. In particular, schizophrenia has been shown to be associated with lesser neurons in the left ventrolateral posterior nucleus, but not the right [38].…”

Section: Discussionmentioning

confidence: 99%

Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid‐positive mild cognitive impairment is associated with key clinical features

Low

Mak

Malpetti

et al. 2019

Alz & Dem Diag Ass & Dis Mo

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Introduction Although widespread cortical asymmetries have been identified in Alzheimer's disease (AD), thalamic asymmetries and their relevance to clinical severity in AD remain unclear. Methods Lateralization indices were computed for individual thalamic subnuclei of 65 participants (33 healthy controls, 14 amyloid‐positive patients with mild cognitive impairment, and 18 patients with AD dementia). We compared lateralization indices across diagnostic groups and correlated them with clinical measures. Results Although overall asymmetry of the thalamus did not differ between groups, greater leftward lateralization of atrophy in the ventral nuclei was demonstrated in AD, compared with controls and amyloid‐positive mild cognitive impairment. Increased posterior ventrolateral and ventromedial nuclei asymmetry were associated with worse cognitive dysfunction, informant‐reported neuropsychiatric symptoms, and functional ability. Discussion Leftward ventral thalamic atrophy was associated with disease severity in AD. Our findings suggest the clinically relevant involvement of thalamic nuclei in the pathophysiology of AD.

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“…In zebrafish, the activation of cannabinoid receptor type-1 (CB1 receptor) in the telencephalon decreased anxiety from acute restraint stress [ 78 ]. Pharmacological activation of the GABAergic system in the telencephalon also reduced the anxiety levels of Japanese medaka [ 79 ]. The thalamus consists of several nuclei and is involved in various functions, including the regulation of anxiety and fear in humans [ 80 ].…”

Section: Discussionmentioning

confidence: 99%

Oxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish

Chuang

Chang

et al. 2021

IJMS

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The oxytocin system plays a role in stress responses and behavior modulation. However, the effects of oxytocin signaling on stress adaptation remain unclear. Here, we demonstrated the roles of oxytocin signaling as a biomarker under stress conditions in the peripheral tissues (the gills) and central nervous system (the brain). All the environmental stressors downregulated the expression of oxytocin receptors in the gills, and the alteration of the expression of oxytocin receptors was also found in the brain after the acidic (AC) and high-ammonia (HA) treatments. The number of oxytocin neurons was increased after double-deionized (DI) treatment. By transgenic line, Tg(oxtl:EGFP), we also investigated the projections of oxytocin neurons and found oxytocin axon innervations in various nuclei that might regulate the anxiety levels and aggressiveness of adult zebrafish under different environmental stresses. The oxytocin system integrates physiological responses and behavioral outcomes to ensure environmental adaptation in adult zebrafish. Our study provides insight into oxytocin signaling as a stress indicator upon environmental stressors.

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Thalamic shape and volume abnormalities in female patients with panic disorder

Cited by 23 publications

References 54 publications

Shared and unique neural circuitry underlying temporally unpredictable threat and reward processing

Shared and unique neural circuitry underlying temporally unpredictable threat and reward processing

Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid‐positive mild cognitive impairment is associated with key clinical features

Oxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish

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