Thalamic structures and associated cognitive functions: Relations with age and aging

Fama, Rosemary; Sullivan, Edith V.

doi:10.1016/j.neubiorev.2015.03.008

Cited by 260 publications

(186 citation statements)

References 77 publications

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“…The relevance of thalamic macrostructural changes during healthy human aging is being progressively recognized (62). Our findings of largest gray matter volumetric reduction in the thalamus over time are in agreement with the results of one (21) out of the three previous longitudinal VBM investigations of healthy elderly samples carried out to date (21,31,32).…”

Section: Discussionsupporting

confidence: 90%

“…The thalamus is nowadays recognized as critical to several aspects of normal cognitive functioning, including memory, processing speed, attention and executive functions (62). In our VBM investigation, a trend significant correlation was found between reduced gray matter volume in the right thalamus and the degree of cognitive performance change over time,…”

Section: Discussionmentioning

confidence: 48%

“…However, healthy elderly subjects did display decreased thalamic volumes relative to younger adults in a number of ROI-based cross-sectional comparisons (12,62).…”

Section: Discussionmentioning

confidence: 99%

“…suggesting that gray matter volume shrinkage in this brain region may be relevant to explain the subtle cognitive deficits that progressively occur during healthy aging (62,63).…”

Section: Discussionmentioning

confidence: 99%

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Padrões de atrofia cortical e declínio cognitivo associado ao envelhecimento saudável: um estudo de seguimento por ressonância magnética estrutural

Silveira¹

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 48%

“…However, healthy elderly subjects did display decreased thalamic volumes relative to younger adults in a number of ROI-based cross-sectional comparisons (12,62).…”

Section: Discussionmentioning

confidence: 99%

“…suggesting that gray matter volume shrinkage in this brain region may be relevant to explain the subtle cognitive deficits that progressively occur during healthy aging (62,63).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Padrões de atrofia cortical e declínio cognitivo associado ao envelhecimento saudável: um estudo de seguimento por ressonância magnética estrutural

Silveira¹

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“…The thalamus is an important transition nucleus and plays a pivotal role in a number of neuronal activities. Areas of the thalamus are considered to play a role in the formation of new memories partly through their connections with the hippocampus, and partly because the thalamus is important for mental alertness [4]. Normal sleep architecture and arousal also require an intact thalamus.…”

Section: Introductionmentioning

confidence: 99%

Sleep and Cognitive Abnormalities in Acute Minor Thalamic Infarction

Cui

et al. 2016

Neurosci. Bull.

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In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction (AMTI), we enrolled 27 patients with AMTI and 12 matched healthy individuals. Questionnaires about sleep and cognition as well as polysomnography (PSG) were performed on days 14 and 90 post-stroke. Compared to healthy controls, in patients with AMTI, hyposomnia was more prevalent; sleep architecture was disrupted as indicated by decreased sleep efficiency, increased sleep latency, and decreased non-rapid eye movement sleep stages 2 and 3; more sleep-related breathing disorders occurred; and cognitive functions were worse, especially memory. While sleep apnea and long-delay memory recovered to a large extent in the patients, other sleep and cognitive function deficit often persisted. Patients with AMTI are at an increased risk for hyposomnia, sleep structure disturbance, sleep apnea, and memory deficits. Although these abnormalities improved over time, the slow and incomplete improvement suggest that early management should be considered in these patients.

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Association of Pediatric Acute-Onset Neuropsychiatric Syndrome With Microstructural Differences in Brain Regions Detected via Diffusion-Weighted Magnetic Resonance Imaging

et al. 2020

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IMPORTANCE Epidemiological studies indicate a link between obsessive-compulsive disorder and infections, particularly streptococcal pharyngitis. Pediatric acute-onset neuropsychiatric syndrome (PANS) manifests suddenly with obsessions, compulsions, and other behavioral disturbances, often after an infectious trigger. The current working model suggests a unifying inflammatory process involving the central nervous system, particularly the basal ganglia. OBJECTIVE To investigate whether diffusion-weighted magnetic resonance imaging (DWI) detects microstructural abnormalities across the brain regions of children with PANS. DESIGN, SETTING, AND PARTICIPANTS Case-control study performed at a single-center, multidisciplinary clinic in the United States focusing on the evaluation and treatment of children with PANS. Sixty consecutive patients who underwent 3 Tesla (T) magnetic resonance imaging (MRI) before immunomodulation from September 3, 2012, to March 30, 2018, were retrospectively reviewed for study inclusion. Six patients were excluded by blinded investigators because of imaging or motion artifacts, 3 patients for major pathologies, and 17 patients for suboptimal atlas image registration. In total, 34 patients with PANS before initiation of treatment were compared with 64 pediatric control participants. MAIN OUTCOMES AND MEASURESUsing atlas-based MRI analysis, regional brain volume, diffusion, and cerebral blood flow were measured in the cerebral white matter, cerebral cortex, thalamus, caudate, putamen, pallidum, hippocampus, amygdala, nucleus accumbens, and brainstem.An age and sex-controlled multivariable analysis of covariance was used to compare patients with control participants. RESULTSThis study compared 34 patients with PANS (median age, 154 months; age range, 55-251 months; 17 girls and 17 boys) and 64 pediatric control participants (median age, 139 months; age range, 48-213 months); 41 girls and 23 boys). Multivariable analysis demonstrated a statistically significant difference in MRI parameters between patients with PANS and control participants (F 21,74 = 6.91; P < .001; partial η 2 = 0.662). All assessed brain regions had statistically significantly increased median diffusivity compared with 64 control participants. Specifically, the deep gray matter (eg, the thalamus, basal ganglia, and amygdala) demonstrated the most profound increases in diffusivity consistent with the cardinal clinical symptoms of obsessions, compulsions, emotional dysregulation, and sleep disturbances. No statistically significant differences were found regarding volume and cerebral blood flow. (continued) Key Points Question How does diffusion-weighted magnetic resonance imaging differ between patients with pediatric acuteonset neuropsychiatric syndrome and pediatric control participants? Findings In this case-control study of 34 consecutive patients with pediatric acute-onset neuropsychiatric syndrome who had 3 Tesla magnetic resonance imaging, all assessed brain regions, particularly the deep gray matter (eg, the thalamus, b...

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Thalamic structures and associated cognitive functions: Relations with age and aging

Cited by 260 publications

References 77 publications

Padrões de atrofia cortical e declínio cognitivo associado ao envelhecimento saudável: um estudo de seguimento por ressonância magnética estrutural

Padrões de atrofia cortical e declínio cognitivo associado ao envelhecimento saudável: um estudo de seguimento por ressonância magnética estrutural

Sleep and Cognitive Abnormalities in Acute Minor Thalamic Infarction

Association of Pediatric Acute-Onset Neuropsychiatric Syndrome With Microstructural Differences in Brain Regions Detected via Diffusion-Weighted Magnetic Resonance Imaging

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