Thalamic taste nuclei lesions and taste aversion

Loullis, Costas C.; Wayner, M.J.; Jolicoeur, F.B.

doi:10.1016/0031-9384(78)90259-7

Cited by 33 publications

(28 citation statements)

References 13 publications

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“…Early research favored a role for the GT in CTA acquisition (e.g., Lasiter, 1985;Loullis, Wayner, & Jolicoeur, 1978;Yamamoto, 1993;Yamamoto & Fujimoto, 1991;Yamamoto et al 1995). However, more recent research, using electrolytic lesions that caused minimal damage beyond the boundaries of the GT, finds no evidence that discrete GT lesions disrupt first-order CTA (e.g., Flynn, Grill, Schulkin, & Norgren, 1991;Grigson, Lyuboslavsky, & Tanase, 2000;Reilly & Pritchard, 1996).…”

Section: Discussionmentioning

confidence: 99%

C-fos expression in the rat brain following lithium chloride-induced illness

2007

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The present study examined c-Fos expression in selected brain areas consequent to administration of lithium chloride, the typical illness-inducing agent used in laboratory studies of conditioned taste aversion. The results replicated previous findings of significant c-Fos expression in the parabrachial nucleus, the central nucleus of the amygdala and the basolateral amygdala. New findings indicate significant lithium-induced c-Fos in the gustatory region of the thalamus and the bed nucleus of the stria terminalis but not in the insular cortex. The results are discussed with respect to the neural substrates of conditioned taste aversion.

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Section: Discussionmentioning

confidence: 99%

C-fos expression in the rat brain following lithium chloride-induced illness

2007

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“…The degree to which this may also be true for the modulation of learned taste preferences (e.g., Garcia, Ervin, Yorke, & Koelling, 1967;Rozin & Kalat, 1971) remains to be determined. Loullis, Wayner, and Jolicoeur (1978) reported that some capacity to acquire a taste aversion habit appeared to be present in rats with gustatory thalamus lesions, although severe attenuation of learning was found. However, the experiment did not include controls for sensitization effects or for assessing the discriminative specificity of the taste aversion.…”

Section: Gustatory Thalamus and Amygdalamentioning

confidence: 99%

The gustatory neocortex of the rat

1982

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Research findings related to the functional significance of the gustatory neocortical system of the rat are reviewed and interpreted. Studies of gustatory neocortex (GN) involvement in taste-related cognitive processes are emphasized after briefly reviewing GN anatomy and physiology. Evidence is presented supporting the conclusion that the GN contributes relatively little to fundamental taste reactivity, but is deeply involved in cognitive (learning and memorial) taste processes; that is, "reactive salience" to taste stimuli is preserved following GN ablation, while "associative salience" is markedly degraded. Apparent functional similarities between GN and other sensory neocortical areas are emphasized throughout the paper, and a hierarchical view of gustatory system functioning is addressed.Patton began his 1950 review of the chemical senses by pointing out that taste and smell essentially had been neglected relative to the other sensory systems. As a partial explanation for this neglect, he men-

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“…For example, whereas the afferent projections from the PbN to the VPMpc were well documented, the efferent projections from the VPMpc to the PbN were not demonstrated (4,21,64). In addition, while earlier studies have shown that the VPMpc is involved in taste detection and discrimination (32), sodium appetite (30,44), and CTA (37,92,93), more recent studies have demonstrated that the VPMpc has a minimal influence on innate taste preference (15,62,78), sodium appetite (14,65), or CTA (14,65). Thorough reviews of earlier studies suggested that the claim of the involvement of VPMpc in taste preference, sodium appetite, and CTA were derived from the lesions that were misplaced, inordinately large, or destroyed fibers of passage (58,60,69).…”

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confidence: 96%

Modulation of activity of gustatory neurons in the hamster parabrachial nuclei by electrical stimulation of the ventroposteromedial nucleus of the thalamus

Mao¹,

Cho²,

Li³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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(VPMpc) is positioned at the key site between the gustatory parabrachial nuclei (PbN) and the gustatory cortex for relaying and processing gustatory information via the thalamocortical pathway. Although neuroanatomical and electrophysiological studies have provided information regarding the gustatory projection from PbN to VPMpc, the exact relationship between PbN and VPMpc, especially the efferent projection involving VPMpc to PbN, is obscure. Here we investigated the reciprocal connection between these two gustatory relays in urethaneanesthetized hamsters. We recorded from 114 taste-responsive neurons in the PbN and examined their responsiveness to electrical stimulation of the VPMpc bilaterally. Stimulation of either or both of the ipsilateral or contralateral VPMpc antidromically activated 109 gustatory PbN neurons. Seventy-two PbN neurons were antidromically activated after stimulation of both sides of the VPMpc, indicating that taste neurons in the PbN project heavily to the bilateral VPMpc. Stimulation of VPMpc also orthodromically activated 110 of PbN neurons, including 106 VPMpc projection neurons. Seventyeight neurons were orthodromically activated bilaterally. Among orthodromic activations of the PbN cells, the inhibitory response was the dominant response; 106 cells were inhibited, including 10 neurons that were also excited contralaterally, indicating that taste neurons in the PbN are subject to strong inhibitory control from VPMpc. Moreover, stimulation of VPMpc altered taste responses of the neurons in the PbN, indicating that VPMpc modulates taste responses of PbN neurons. These results may provide functional insight of neural circuitry for taste processing and modulation involving these two nuclei.central gustatory pathway; pons; electrophysiology THE PARABRACHIAL NUCLEI (PbN) and the parvicellular part of the ventroposteromedial nucleus of the thalamus (VPMpc) are the second and tertiary central relays for taste information processing in rodents, respectively (4,13,17,28,45,49,51). Gustatory information elicited from the tongue and oropharyngeal cavity is initially carried to the rostral portion of the nucleus of the solitary tract (NST) by the VIIth, IXth, and Xth cranial nerves, and these terminals are distributed in a topographic fashion with rostral-caudal sequence in the rostral NST (2,9,23,24,89). From the NST, ascending gustatory fibers project to third-order taste cells within the PbN of the pons (7,22,42,46,(53)(54)(55)87). Two separate routes carry taste information from the PbN further to the forebrain taste areas and cortex: the ventral forebrain pathway that involves the central nucleus of the amygdala (CeA), the lateral hypothalamus (LH), the bed nucleus of the stria terminalis (BNST), the substantia innominata (3,12,16,21,31,33,34,41,47,63,64,71); and the thalamocortical pathway that is characterized by the involvement of the bilateral VPMpc, which, in turn, carries taste information to the gustatory cortex (GC) (5,25,45,48,51).The PbN is a critical neural substrate for a number...

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Thalamic taste nuclei lesions and taste aversion

Cited by 33 publications

References 13 publications

C-fos expression in the rat brain following lithium chloride-induced illness

C-fos expression in the rat brain following lithium chloride-induced illness

The gustatory neocortex of the rat

Modulation of activity of gustatory neurons in the hamster parabrachial nuclei by electrical stimulation of the ventroposteromedial nucleus of the thalamus

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