Thalamic Visual Prosthesis Project

Kyada, Margee J.; Killian, Nathaniel J.; Pezaris, John S.

doi:10.1007/978-3-319-41876-6_14

Cited by 8 publications

(2 citation statements)

References 55 publications

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“…So far, there have been very few preclinical studies in animals conducted to test the stimulation efficacy [81,83,84]. With future advancements from the technological point of view, LGN visual prostheses could start to carve their way into a feasible solution for patients [85].…”

Section: Thalamic Prosthesesmentioning

confidence: 99%

Advances in visual prostheses: engineering and biological challenges

Borda

Ghezzi²

2022

Prog. Biomed. Eng.

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Vision is an extraordinary sense through which we can appreciate the beauty of the world we live in, gain invaluable knowledge and communicate with others using visual expression and arts. On the contrary, blindness is a threatening medical condition disrupting the life of affected people and their families. Therefore, restoring sight is one of the open challenges of our society. Today, the synergistic convergence of science and technology holds the potential to provide blind patients with artificial vision using visual prostheses: a type of implantable medical device able to reactivate visual neurons using electrical stimulation. Although clinical trials showed that vision restoration is still far away, significant technological advances make visual prostheses a valuable solution for blind patients. This review is not only a description of the state-of-the-art. Instead, it provides the reader with an update on recent developments, a critical discussion of the open challenges, and an overview of promising future directions.

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Section: Thalamic Prosthesesmentioning

confidence: 99%

Advances in visual prostheses: engineering and biological challenges

Borda

Ghezzi²

2022

Prog. Biomed. Eng.

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“…The most important limitation, though, is that although Alpha IMS consists of a 1500 photodiode array, visual acuity remains unexpectedly poor and clinical outcomes are highly inconclusive (for a review see Zrenner et al, 2017). Simulation studies from other groups have demonstrated that 500 distinct phosphenes can provide useful visual information in letter recognition and reading tasks (Sommerhalder et al, 2004; Kyada et al, 2017), as well as in navigational, mobility and visuomotor coordination tasks (Perez Fornos et al, 2008). Thus, given the high phosphene density offered by Alpha IMS, one would expect improved functional outcomes in patients using the device.…”

Section: Gaze Compensation In Artificial Visionmentioning

confidence: 99%

Eye Movement Compensation and Spatial Updating in Visual Prosthetics: Mechanisms, Limitations and Future Directions

Paraskevoudi

Pezaris

2019

Front. Syst. Neurosci.

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Despite appearing automatic and effortless, perceiving the visual world is a highly complex process that depends on intact visual and oculomotor function. Understanding the mechanisms underlying spatial updating (i.e., gaze contingency) represents an important, yet unresolved issue in the fields of visual perception and cognitive neuroscience. Many questions regarding the processes involved in updating visual information as a function of the movements of the eyes are still open for research. Beyond its importance for basic research, gaze contingency represents a challenge for visual prosthetics as well. While most artificial vision studies acknowledge its importance in providing accurate visual percepts to the blind implanted patients, the majority of the current devices do not compensate for gaze position. To-date, artificial percepts to the blind population have been provided either by intraocular light-sensing circuitry or by using external cameras. While the former commonly accounts for gaze shifts, the latter requires the use of eye-tracking or similar technology in order to deliver percepts based on gaze position. Inspired by the need to overcome the hurdle of gaze contingency in artificial vision, we aim to provide a thorough overview of the research addressing the neural underpinnings of eye compensation, as well as its relevance in visual prosthetics. The present review outlines what is currently known about the mechanisms underlying spatial updating and reviews the attempts of current visual prosthetic devices to overcome the hurdle of gaze contingency. We discuss the limitations of the current devices and highlight the need to use eye-tracking methodology in order to introduce gaze-contingent information to visual prosthetics.

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Advances in Neuroscience, Not Devices, Will Determine the Effectiveness of Visual Prostheses

Abbasi

Rizzo

2021

Seminars in Ophthalmology

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Thalamic Visual Prosthesis Project

Cited by 8 publications

References 55 publications

Advances in visual prostheses: engineering and biological challenges

Advances in visual prostheses: engineering and biological challenges

Eye Movement Compensation and Spatial Updating in Visual Prosthetics: Mechanisms, Limitations and Future Directions

Advances in Neuroscience, Not Devices, Will Determine the Effectiveness of Visual Prostheses

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