Thalamic volume loss as an early sign of amnestic mild cognitive impairment

Zidan, Mousa; Boban, Jasmina; Bjelan, Mladen; Todorović, Aleksandar; Vujanić, Tijana Stankov; Semnic, Marija; Boban, Nikola; Kozić, Duško

doi:10.1016/j.jocn.2019.07.004

Cited by 24 publications

(24 citation statements)

References 52 publications

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“…As for the results on subcortical volumes of the two groups, non-exercise group demonstrated reduced volumes of thalamus, caudate, putamen, pallidum, hippocampus, amygdala. Thalamic volume loss was proposed to be an early indicator of poorer cognitive performance in amnestic MCI patients in one study, 43 and early involvement of thalamus and striatum were noted in familial AD patients. 44 Moreover, subcortical volume loss increased the risk of conversion from MCI to AD.…”

Section: Discussionmentioning

confidence: 99%

Effects of Moderate Intensity Exercise on the Cortical Thickness and Subcortical Volumes of Preclinical Alzheimer’s Disease Patients: A Pilot Study

Wang

Kim

et al. 2020

Psychiatry Investig

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Objective We aimed to explore the impact of moderate intensity exercise on the cortical thickness and subcortical volumes of preclinical Alzheimer’s disease (AD) patients.Methods Sixty-three preclinical AD patients with magnetic resonance imaging (MRI) and 18-florbetaben positron emission tomography (PET) data were enrolled in the study. Information on demographic characteristics, cognitive battery scores, self-reported exercise habits were attained. Structural magnetic resonance images were analyzed and processed using Freesurfer v6.0.Results Compared to Exercise group, Non-Exercise group demonstrated reduced cortical thickness in left parstriangularis, rostral middle frontal, entorhinal, superior frontal, lingual, superior parietal, lateral occipital, inferior parietal gyrus, temporal pole, precuneus, insula, fusiform gyrus, right precuneus, superiorparietal, lateral orbitofrontal, rostral middle frontal, medial orbitofrontal, superior frontal, lingual, middle temporal gyrus, insula, supramarginal, parahippocampal, paracentral gyrus. Volumes of right thalamus, caudate, putamen, pallidum, hippocampus, amygdala were also reduced in Non-Exercise group.Conclusion Moderate intensity exercise affects cortical and subcortical structures in preclinical AD patients. Thus, physical exercise has a potential to be an effective intervention to prevent future cognitive decline in those at high risk of AD.

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Section: Discussionmentioning

confidence: 99%

Effects of Moderate Intensity Exercise on the Cortical Thickness and Subcortical Volumes of Preclinical Alzheimer’s Disease Patients: A Pilot Study

Wang

Kim

et al. 2020

Psychiatry Investig

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“…Thalamic volume loss was observed in both AD and aMCI patients, and in these latter subjects it was an early sign associated with poor cognitive performance preceding the damage to other extra-hippocampal brain regions such as the amygdala. 70 Compared with both MCI and SCD patients, a larger caudate nucleus volume, partially associated with age and female sex, was observed in AD patients and interpreted as result of pathology accumulation or mechanism of temporary compensation (i.e. to compensate for the reduced hippocampal volumes).…”

Section: Resultsmentioning

confidence: 89%

Section: New Brain Regions Of Interestmentioning

confidence: 99%

An update on magnetic resonance imaging markers in AD

Leocadi

Canu

Calderaro

et al. 2020

Ther Adv Neurol Disord

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The purpose of the present review is to provide an update of the available recent scientific literature on the use of magnetic resonance imaging (MRI) in Alzheimer’s disease (AD). MRI is playing an increasingly important role in the characterization of the AD signatures, which can be useful in both the diagnostic process and monitoring of disease progression. Furthermore, this technique is unique in assessing brain structure and function and provides a deep understanding of in vivo evolution of cerebral pathology. In the reviewing process, we established a priori criteria and we thoroughly searched the very recent scientific literature (January 2018–March 2020) for relevant articles on this topic. In summary, we selected 73 articles out of 1654 publications retrieved from PubMed. Based on this selection, this review summarizes the recent application of MRI in clinical trials, defining the predementia stages of AD, the clinical utility of MRI, proposal of novel biomarkers and brain regions of interest, and assessing the relationship between MRI and cognitive features, risk and protective factors of AD. Finally, the value of a multiparametric approach in clinical and preclinical stages of AD is discussed.

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“…Roughly, volumetric measurements indexed by total intracranial volume (ventricles as a fraction, percentage, of intracranial volume) are the most used method and are helpful to distinguish HA, MCI (amnestic and non‐amnestic), and AD; however, serial measurements seem to be more accurate than unique ones 67 . The addition of biomarkers, such as Aβ (Aβ 42 ), total tau protein, and phosphorylated tau (p‐tau 181 ), to these volumes has improved the diagnostic accuracy 24,68,69 …”

Section: Resultsmentioning

confidence: 99%

Brain ventricles, CSF and cognition: a narrative review

et al. 2022

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The brain ventricles are structures that have been related to cognition since antiquity. They are essential components in the development and maintenance of brain functions. The aging process runs with the enlargement of ventricles and is related to a less selective blood‐cerebrospinal fluid barrier and then a more toxic cerebrospinal fluid environment. The study of brain ventricles as a biological marker of aging is promissing because they are structures easily identified in neuroimaging studies, present good inter‐rater reliability, and measures of them can identify brain atrophy earlier than cortical structures. The ventricular system also plays roles in the development of dementia, since dysfunction in the clearance of beta‐amyloid protein is a key mechanism in sporadic Alzheimer's disease. The morphometric and volumetric studies of the brain ventricles can help to distinguish between healthy elderly and persons with mild cognitive impairment (MCI) and dementia. Brain ventricle data may contribute to the appropriate allocation of individuals in groups at higher risk for MCI‐dementia progression in clinical trials and to measuring therapeutic responses in these studies, as well as providing differential diagnosis, such as normal pressure hydrocephalus. Here, we reviewed the pathophysiology of healthy aging and cognitive decline, focusing on the role of the choroid plexus and brain ventricles in this process.

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Thalamic volume loss as an early sign of amnestic mild cognitive impairment

Cited by 24 publications

References 52 publications

Effects of Moderate Intensity Exercise on the Cortical Thickness and Subcortical Volumes of Preclinical Alzheimer’s Disease Patients: A Pilot Study

Effects of Moderate Intensity Exercise on the Cortical Thickness and Subcortical Volumes of Preclinical Alzheimer’s Disease Patients: A Pilot Study

An update on magnetic resonance imaging markers in AD

Brain ventricles, CSF and cognition: a narrative review

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