Thalamo-hippocampal pathway regulates incidental memory capacity in mice

Torromino, Giulia; Loffredo, Vittorio; Cavezza, D.; Sonsini, G; Esposito, Federica; Crevenna, Álvaro H.; Gioffrè, M.; Risi, Maria De; Treves, Alessandro; Griguoli, Marilena; Leonibus, Elvira De

doi:10.1038/s41467-022-31781-8

Cited by 14 publications

(12 citation statements)

References 62 publications

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“…and this may be the reason of the highlighted association of hippocampus with all three self-reported negative emotions in females. There have been many rodent-based studies trying to validate the more rigorous role of hippocampus in memory consolidation in females than males (Qi et al, 2016; Soler et al, 2021; Torromino et al, 2022; C. L. Williams & Meck, 1991). Hippocampal memory and female estrogen control have an established relation.…”

Section: Discussionmentioning

confidence: 99%

Sex-specific brain effective connectivity patterns associated with negative emotions

Sultana,

Ijaz,

Khan

et al. 2024

Preprint

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Sex differences in effective brain connectivity in emotional intelligence, emotional regulation, and stimuli-induced negative emotions have been highlighted in previous research. However, to our knowledge, no research has yet investigated the sex-specific effective connectivity related to negative emotions in healthy population during resting-state. The goal of this study is to find the association between sex-specific resting-state effective brain connectivity and basic negative emotions. For this, we have employed the NIH emotion battery of the three self-reported, basic negative emotions: anger-affect, fear-affect, and sadness which we divided into high, moderate, and low emotion scores in each. The dataset comprises 1079 subjects (584 females) from HCP Young Adults. We selected large-scale resting-state brain networks important for emotional processing namely default mode, executive, and salience networks. We employed subject-level analysis using spectral dynamic causal modelling and group-level association analyses using parametric empirical Bayes. We report association of the self-connection of left hippocampus in females in high anger-affect, fear-affect, and sadness, whereas in males we found involvement of dorsal anterior cingulate cortex (dACC) in all three negative emotions - association of right amygdala to dACC in high anger-affect, association of the self-connection of dACC in high fear-affect, and association of dACC to left hippocampus in high sadness. Our findings primarily revealed the effective brain connectivity that is related to the higher levels of negative emotions that may lead to psychiatric disorders if not regulated. Sex-specific therapies and interventions that target psychopathology can be more beneficial when informed by the sex-specific resting-state effective connectivity.

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Section: Discussionmentioning

confidence: 99%

Sex-specific brain effective connectivity patterns associated with negative emotions

Sultana,

Ijaz,

Khan

et al. 2024

Preprint

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“…During the study phase, animals were allowed to explore each different object for 35 s, meaning that they were allowed to collect a total of 35 s and 210 s in the 6-IOT and 6-DOT, in 5 min or 10 min maximum duration time, respectively. The different set of objects used were chosen based on pilot experiments that allowed to avoid basal differences for any of the sample objects and was identical to that used in previous studies 23 , 24 , 53 , 55 . After an inter-trial interval of 1 min, mice were exposed for 5 min to identical copies of the objects of the study phase, of which one was replaced by a novel object (test trial).…”

Section: Methodsmentioning

confidence: 99%

Synaptic mechanisms underlying onset and progression of memory deficits caused by hippocampal and midbrain synucleinopathy

Iemolo

Risi

Giordano

et al. 2023

npj Parkinsons Dis.

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Cognitive deficits, including working memory, and visuospatial deficits are common and debilitating in Parkinson’s disease. α-synucleinopathy in the hippocampus and cortex is considered as the major risk factor. However, little is known about the progression and specific synaptic mechanisms underlying the memory deficits induced by α-synucleinopathy. Here, we tested the hypothesis that pathologic α-Synuclein (α-Syn), initiated in different brain regions, leads to distinct onset and progression of the pathology. We report that overexpression of human α-Syn in the murine mesencephalon leads to late onset memory impairment and sensorimotor deficits accompanied by reduced dopamine D1 expression in the hippocampus. In contrast, human α-Syn overexpression in the hippocampus leads to early memory impairment, altered synaptic transmission and plasticity, and decreased expression of GluA1 AMPA-type glutamate receptors. These findings identify the synaptic mechanisms leading to memory impairment induced by hippocampal α-synucleinopathy and provide functional evidence of the major neuronal networks involved in disease progression.

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“…Indeed, several astrocytic factors that can be regulated by GPCRs have been implicated in sex-specific effects, including cAMP response element-binding protein (CREB) (61)(62)(63), nuclear factor-ĸB (64,65), and superoxide dismutase 2 (66). Astrocytic receptor signaling might also engage sex-specific neuronal mechanisms that result in distinct functional outcomes in a non-cell autonomous manner (13,16,67,68). Further investigations are required to unravel if and how potential astrocyte-intrinsic and extrinsic neural circuit mechanisms mediate the divergent sex-specific effects of different astrocytic receptors, including mGluR3.…”

Section: Main Textmentioning

confidence: 99%

Astrocytes regulate spatial memory in a sex-specific manner

Meadows

Palaguachi

Licht-Murava

et al. 2022

Preprint

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Cognitive processes and neurocognitive disorders are regulated by astrocytes and have prominent sex differences. However, the contribution of astrocytes to sex differences is not known. We leveraged astrocyte-targeted gene editing and chemogenetics in adult mice to reveal that astrocytic glutamate receptors and other G protein-coupled receptors (GPCRs) modulate hippocampus-dependent cognitive function in a sexually dimorphic manner. In females, spatial memory was improved by increasing metabotropic glutamate receptor 3 (mGluR3) in astrocytes or stimulating astrocytic Gi/o-coupled signaling, whereas stimulating Gs-coupled signaling impaired memory. However, in males, memory was improved by reducing mGluR3 or stimulating Gs-coupled signaling, whereas stimulating Gi/o-coupled signaling impaired memory. Thus, memory requires a sex-specific balance of astrocytic Gs-coupled and Gi/o-coupled receptor activities, and disease-associated alterations or therapeutic targeting of these pathways may cause opposing sex-dependent effects on cognitive function.

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Thalamo-hippocampal pathway regulates incidental memory capacity in mice

Cited by 14 publications

References 62 publications

Sex-specific brain effective connectivity patterns associated with negative emotions

Sex-specific brain effective connectivity patterns associated with negative emotions

Synaptic mechanisms underlying onset and progression of memory deficits caused by hippocampal and midbrain synucleinopathy

Astrocytes regulate spatial memory in a sex-specific manner

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