Thalamocortical connections of rat posterior parietal cortex

Chandler, Howard C.; King, Von R.; Corwin, James V.; Reep, Roger L.

doi:10.1016/0304-3940(92)90273-a

Cited by 74 publications

(53 citation statements)

References 8 publications

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“…The boundaries for measuring PRh were determined from those previously defined by Burwell and colleagues (Burwell et al, 1995;Burwell and Amaral, 1998;Burwell, 2001). Although there is still some controversy regarding the exact boundaries of rat PPC, we referred to the region as defined in previous studies by thalamic and cortical connectivity (Chandler et al, 1992;Reep et al, 1994). Accordingly, we considered PPC to occupy the area of cortex located ϳ3.5-5.0 mm caudal to bregma and 1.5-5.0 mm lateral to the midline suture (Bucci, 2009;Kesner, 2009;Reep and Corwin, 2009).…”

Section: Methodsmentioning

confidence: 99%

A Distributed Cortical Representation Underlies Crossmodal Object Recognition in Rats

Winters¹,

Reid²

2010

J. Neurosci.

111

121

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The mechanisms by which the brain integrates the unimodal sensory features of an object into a comprehensive multimodal object representation are poorly understood. We have recently developed a procedure for assessing crossmodal object recognition (CMOR) and object feature binding in rats using a modification of the spontaneous object recognition (SOR) paradigm. Here we show for the first time that rats are capable of spontaneous crossmodal object recognition when they are asked to recognize a visually presented object having previously only explored the tactile features of that object. Moreover, rats with bilateral perirhinal cortex (PRh) lesions were impaired on the CMOR task and a visual-only, but not a tactile-only, version of SOR. Conversely, rats with bilateral posterior parietal cortex (PPC) lesions were impaired on the CMOR and tactile-only tasks but not the visual-only task. Finally, crossmodal object recognition ability was severely and selectively impaired in rats with unilateral lesions made to PRh and PPC in opposite hemispheres. Thus, spontaneous tactile-to-visual crossmodal object recognition in rats relies on an object representation that requires functional interaction between PRh and PPC, which appear to mediate the visual and tactile information-processing demands of the task, respectively. These results imply that, at least under certain conditions, the separate sensory features of an object are represented in a distributed manner in the cortex. The novel paradigm introduced here should be a valuable tool for further study of the neurobiological bases of crossmodal cognition and object feature binding.

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Section: Methodsmentioning

confidence: 99%

A Distributed Cortical Representation Underlies Crossmodal Object Recognition in Rats

Winters¹,

Reid²

2010

J. Neurosci.

111

121

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show abstract

“…The PPC, characterized by multimodal sensory projections that reciprocally connect with the frontal association cortex, has strong connections with visual areas (29)(30)(31). PPC and visual association cortex share functional attributes as well as corticocortical connections with medial agranular cortex and orbital cortex (32). It has been suggested that the role of PPC is to use visual sensory input to help guide movements (29).…”

Section: Discussionmentioning

confidence: 99%

Constituents and functional implications of the rat default mode network

Hsu

Liang

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

100

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The default mode network (DMN) has been suggested to support a variety of self-referential functions in humans and has been fractionated into subsystems based on distinct responses to cognitive tasks and functional connectivity architecture. Such subsystems are thought to reflect functional hierarchy and segregation within the network. Because preclinical models can inform translational studies of neuropsychiatric disorders, partitioning of the DMN in nonhuman species, which has previously not been reported, may inform both physiology and pathophysiology of the human DMN. In this study, we sought to identify constituents of the rat DMN using resting-state functional MRI (rs-fMRI) and diffusion tensor imaging. After identifying DMN using a group-level independent-component analysis on the rs-fMRI data, modularity analyses fractionated the DMN into an anterior and a posterior subsystem, which were further segregated into five modules. Diffusion tensor imaging tractography demonstrates a close relationship between fiber density and the functional connectivity between DMN regions, and provides anatomical evidence to support the detected DMN subsystems. Finally, distinct modulation was seen within and between these DMN subcomponents using a neurocognitive aging model. Taken together, these results suggest that, like the human DMN, the rat DMN can be partitioned into several subcomponents that may support distinct functions. These data encourage further investigation into the neurobiological mechanisms of DMN processing in preclinical models of both normal and disease states.default mode network | functional connectivity | modularity | rat brain | aging T he default mode network (DMN) of the brain, first demonstrated in humans (1) and then in nonhuman primates (2) and rodents (3-5), contains a set of distributed brain regions that are approximately analogous across the species. Anatomically, the human DMN includes medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC) and precuneus, bilateral inferior parietal cortex, temporal cortex, and hippocampus (HIPP) (6, 7). The human DMN is thought to support a variety of self-referential functions, including recollection and imagination, conceptual processing, and autobiographical memory (6,8,9). A reduction of DMN's activity (or deactivation) has been conceptualized as the suppression of brain activity responsible for processing introspective thinking and planning. In so doing, it supports the processing of events external to the individual, including such executive functions as working memory (10). Compared with healthy individuals, various neurological and psychiatric disorders including schizophrenia (11), Alzheimer's disease (12), autism (13), and addiction (14, 15) have been linked to DMN dysregulation.Based on distinct responses to various cognitive tasks and functional connectivity architecture, the human DMN has been fractionated using both graph theory (16) and independentcomponent analysis (ICA) methods (17) into a set of...

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“…Studies using retrograde degeneration or, more recently, axonal tracing techniques provide a very consistent pattern of thalamic inputs. Thalamic afferents involve the lateral dorsal, lateral posterior, and posterior nuclei (McDaniel et al, 1978;Chandler et al, 1992). In contrast with the visual areas or somatosensory areas, the APC does not receive projection from the ventrobasal and dorsal lateral geniculate nuclei (Chandler et al, 1992;Reep et al, 1994).…”

Section: Neuroanatomical Interactions Between the Apc And The Hippocamentioning

confidence: 99%

“…Thalamic afferents involve the lateral dorsal, lateral posterior, and posterior nuclei (McDaniel et al, 1978;Chandler et al, 1992). In contrast with the visual areas or somatosensory areas, the APC does not receive projection from the ventrobasal and dorsal lateral geniculate nuclei (Chandler et al, 1992;Reep et al, 1994). Most importantly, injections of retrograde tracers in the parietal area and connected structures allowed researchers to determine the cortico-cortical connections of the APC and to distinguish this area from the secondary visual areas (Kolb and Walkey, 1987;Reep et al, 1994).…”

Section: Neuroanatomical Interactions Between the Apc And The Hippocamentioning

confidence: 99%

Hippocampal-parietal cortical interactions in spatial cognition

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Poucet

2000

Hippocampus

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Growing evidence suggests that the associative parietal cortex (APC) of the rat is involved in the processing of spatial information. This observation raises the issue of the respective functions of the APC and the hippocampus in spatial processing as well as of their possible interactions. In this paper, we review neuroanatomical, electrophysiological, and behavioral data that support the existence of such functional interactions. Our hypothesis is that the APC is involved in the initial combination of visuospatial information and self‐motion information necessary for the integration of egocentrically acquired information into allocentrically coded information, the latter step being completed in the hippocampus. The dialogue between the hippocampus and the APC is therefore crucial, particularly when the elaboration and/or updating of an allocentric representation depends on complex combinations of visuospatial and self‐motion information. Hippocampus 10:491–499, 2000 © 2000 Wiley‐Liss, Inc.

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Thalamocortical connections of rat posterior parietal cortex

Cited by 74 publications

References 8 publications

A Distributed Cortical Representation Underlies Crossmodal Object Recognition in Rats

A Distributed Cortical Representation Underlies Crossmodal Object Recognition in Rats

Constituents and functional implications of the rat default mode network

Hippocampal-parietal cortical interactions in spatial cognition

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