Thalassemia and Nutritional Status in Children

Ayukarningsih, Yoke; Amalia, Jihan; Nurfahfah, Gita

doi:10.54052/jhds.v2n1.p39-52

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…Moreover, the increased energy expenditure, where people with Betathalassemia Major have an increased energy expenditure due to the increased production of red blood cells in the bone marrow. This can result in a higher caloric requirement, which can be difficult to meet, especially if there is malabsorption (22,23).…”

Section: The Resultsmentioning

confidence: 99%

Correlation of Hepcidin with Hemoglobin and Iron Parameters in Iraqi Patients with Beta -Thalassemia major

Nahi,

Jabir

2023

Qad Med J

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Background: Thalassemia is characterized by genetic abnormalities in the synthesis of hemoglobin, leading to a decrease or missing production of one or more in the globin chains. Consequently, this disrupts the synthesis of hemoglobin molecules, resulting in anemia, which is a prominent manifestation of thalassemia. Iron is an essential element for cellular health and is involved in various functions, including oxygen transportation, biomolecule synthesis, respiration, and homeostasis. Hepcidin, a low molecular weight peptide produced in the liver, plays a crucial role in regulating iron homeostasis. Objectives: Study the correlation of Hepcidin with Hemoglobin, Ferritin, and Iron Parameters in Patients with Beta-Thalassemia major. Methods: The serum ferritin of all subjects was measured by the ELFA technique (Enzyme Linked Fluorescent Assay), Serum Hepcidin is measured by the ELISA kit, and Iron, UIBC as well as TIBC are measured via colorimetric methods. Results: The { mean ± SD } of Ages and Genders among Patients with healthy groups were not significant. The { mean ± SD } of Hb and serum levels of Iron, UIBC, TIBC, Hepcidin concentration, and BMI between Patients and healthy groups were statistically significant. The study results of the correlation between Hepcidin and other markers in the beta-thalassemia patient's group showed a non-significant negative correlation of hepcidin with TIBC and UIBC. while there is a non-significant weak correlation between hepcidin with Hb and Ferritin. and the results have shown a non-significant positive correlation between hepcidin and Iron. Conclusion: In this study showed a marked reduction in hemoglobin production and high levels of Iron and Ferritin concentration, while the concentration of TIBC and UIBC was observed to decrease in individuals with this disease compared to healthy individuals. This study showed low hepcidin concentration in ?-TM major patients compared to healthy subjects.

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Section: The Resultsmentioning

confidence: 99%

Correlation of Hepcidin with Hemoglobin and Iron Parameters in Iraqi Patients with Beta -Thalassemia major

Nahi,

Jabir

2023

Qad Med J

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“…Iron buildup can interfere with osteoid maturation and precipitate into hydroxyapatite crystals, disrupting normal bone metabolism (Moiz et al, 2018). In addition, malnutrition in thalassemia patients is caused by ineffective erythropoiesis; rapid turnover of erythrocytes also increases energy requirements (Ayukarningsih et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

Correlation Between Adherence Therapy of Iron Chelation Levels with Anthropometric Status in Major Beta-Thalassemia Patients

Sarı¹,

Permatasari²,

Ismail

2023

ihj

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Thalassemia is a condition in which hemoglobin undergoes hemolysis due to impaired synthesis of hemoglobin or globin chains. Growth failure is a common occurrence in patients with thalassemia. Iron overload due to repeated transfusions will cause disturbances in anthropometric status in children with thalassemia. Iron chelation therapy is needed to overcome iron overload in patients with beta-thalassemia major. The level of adherence affects the success of iron chelation therapy. This study aims to determine the relationship between the level of adherence to iron chelation treatment and anthropometric status in patients with thalassemia beta major at Kediri District General Hospital. This type of research is observational analytic with a cross-sectional design. This research was conducted at the SMF Pediatrics (IKA) RSUD Kediri Regency on 16 subjects with B-thalassemia major using a total sampling technique that met the inclusion criteria. The research instruments used in this study were the Morisky Medication Adherence Scale-8 questionnaire and an examination of anthropometric status. The research analysis used the Spearman correlation test. A p-value <0.05 was considered significant. The results showed that there was a significant results between adherence to iron chelation consumption and height for age (p-value = 0.049 > a 0.05), significant results between adherence to iron chelation consumption with weight for age (p-value = 0.036 < a 0.05), and significant results with weight for height (p-value = 0.001 < a 0.05). This study implies that adherence to iron chelation therapy is essential for thalassemia patients. This study shows that patients more adherent to iron chelation treatment have better anthropometric status.

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“…Beslenme durumu, optimal sağlık durumuna ulaşmadaki faktörlerden biridir (28). Bu çalışmada, talasemi tanılı çocukların yaklaşık yarısı (%52,3) besin desteği kullandığını, en yaygın kullandıkları besin desteğinin D vitamini, folik asit ve çinko olduğunu ifade etmişlerdir.…”

Section: Discussionunclassified

Evaluation of Nutritional Status of Children with Thalassemia

ASLAN ÇİN,

KOÇ

2023

STED

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Amaç: Araştırma 2-17 yaş arası talasemi tanılı çocukların beslenme durumunu incelemek amacıyla yapılmıştır. Yöntem: Araştırma, 86 talasemi hastasından dahil edilme kriterlerini karşılayan ve gönüllü olan 2-17 yaş arası, talasemi tanısı alan 23 çocuk ile yürütülmüştür. Veriler çocukların sosyodemografik özellikleri, beslenme alışkanlıkları, antropometrik ölçümleri, biyokimyasal bulguları ve besin tüketim kaydı sorularından oluşan anket formu ile yüz yüze toplanmıştır. Araştırmadan elde edilen veriler SPSS 25,0 paket programı kullanılarak uygun istatistiki testler kullanılarak değerlendirilmiştir. Bulgular: Katılımcıların %65,2’si kız ve %34,8’i erkek olup, ortalama yaş 10,3±5,2 yıl olarak saptanmıştır. Çalışmaya katılan çocukların tamamının (%100,0) hemoglobin ve hematokrit düzeyleri düşük, ferritin düzeyleri yüksekti. Talasemi hastası çocukların %52,2’si besin desteği kullandığını ve en çok kullandıkları üç besin desteğinin D vitamini (%52,2), folik asit (%26,1) ve çinko (%21,7) olduğu belirlenmiştir. Talasemi hastası kız çocuklarının yaklaşık yarısının enerji (%43,5) ve kalsiyum (%53,3) alımlarının yetersiz olduğu; erkek çocukların enerji (%50,0), folat, (%50,0), C vitamini (%37,5), kalsiyum (%37,5) ve magnezyum (%37,5) alımlarının yetersiz olduğu saptanmıştır. İki-10 yaş aralığındaki çocukların %30,0’unun folat, %40’ının kalsiyum alımlarının yetersiz olduğu saptanmıştır. Bunun yanı sıra, 11-17 yaş aralığındaki çocukların %53,8’inin C vitamini ve kalsiyum, %38,5’inin çinko alımlarının yetersiz olduğu saptanmıştır. Sonuç: Talasemi hastası çocukların makro ve mikro besin ögelerini yetersiz aldığı saptanmıştır. Bu çalışma talasemi tanılı çocukların beslenme yetersizliği açısından risk altında olduğunu saptamak için beslenme izlemine ihtiyaçları olduğunu belirlemiştir. Gelecekteki çalışmalar, Türk talasemi hastası çocuklarda daha geniş örneklemde diyet kalitesi ve beslenme durumunun sağlık sonuçları üzerindeki etkisine doğrudan odaklanmalıdır.

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Thalassemia and Nutritional Status in Children

Cited by 5 publications

References 3 publications

Correlation of Hepcidin with Hemoglobin and Iron Parameters in Iraqi Patients with Beta -Thalassemia major

Correlation of Hepcidin with Hemoglobin and Iron Parameters in Iraqi Patients with Beta -Thalassemia major

Correlation Between Adherence Therapy of Iron Chelation Levels with Anthropometric Status in Major Beta-Thalassemia Patients

Evaluation of Nutritional Status of Children with Thalassemia

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