2020
DOI: 10.3390/md18070354
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Thalassosterol, a New Cytotoxic Aromatase Inhibitor Ergosterol Derivative from the Red Sea Seagrass Thalassodendron ciliatum

Abstract: Thalassodendron ciliatum (Forssk.) Den Hartog is a seagrass belonging to the plant family Cymodoceaceae with ubiquitous phytoconstituents and important pharmacological potential, including antioxidant, antiviral, and cytotoxic activities. In this work, a new ergosterol derivative named thalassosterol (1) was isolated from the methanolic extract of T. ciliatum growing in the Red Sea, along with two known first-reported sterols, namely ergosterol (2) and stigmasterol (3), using different chromatographic … Show more

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Cited by 21 publications
(19 citation statements)
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“…Thalassosterol exhibited significant in vitro antiproliferative potential against the human cervical cancer cell line (HeLa), and human breast cancer (MCF-7) cell lines. Those results aligned with docking studies on the new sterol which explained the possible binding interactions with an aromatase enzyme; this inhibition is beneficial in both cervical and breast cancer therapy [10].…”
supporting
confidence: 67%
“…Thalassosterol exhibited significant in vitro antiproliferative potential against the human cervical cancer cell line (HeLa), and human breast cancer (MCF-7) cell lines. Those results aligned with docking studies on the new sterol which explained the possible binding interactions with an aromatase enzyme; this inhibition is beneficial in both cervical and breast cancer therapy [10].…”
supporting
confidence: 67%
“…exhibited IC 50 values less than 20 mg ml À1 (Table 1), indicating their potent anti-proliferative effects. 25,54 As depicted in Table 1, the n-butanol fraction exerted the greatest inhibitory activity against MCF7 cells, followed by the ethyl acetate fraction, total extract, and acetone fraction, with interesting IC 50 values of 2.30 AE 0.07, 9.96 AE 0.32, 13.95 AE 0.45, and 15.25 AE 0.50 mg ml À1 , respectively, which were even more potent than staurosporine (IC 50 ¼ 20.30 AE 0.6 mg ml À1 ). The petroleum ether fraction, on the other hand, showed weaker cytotoxicity against MCF7 cells (IC 50 ¼ 27.45 AE 0.90 mg ml À1 ).…”
Section: Anti-proliferative Activitymentioning
confidence: 99%
“…18,22 On the other hand, despite their chemical and biological prolicacy, the biogenic synthesis of AgNPs using marine invertebrates has been scarcely explored, 23 encompassing our recent report on the anti-inammatory potential of the biosynthesized AgNPs from the so coral Nephthea sp., which revealed greater anti-COX-2 properties compared with its bulk extracts. 24 Therefore, in continuation of our interest in marine organisms and their bioactive NPs, [24][25][26][27][28] the current study investigates the chemical complexity and anti-proliferative activity of the total extract and different fractions of Nephthea sp., along with the green synthesis of potential anti-proliferative AgNPs using the total so coral extract. Molecular docking analysis was also considered in order to predict the possible binding of the identied metabolites to a number of cancerrelated cellular proteins.…”
Section: Introductionmentioning
confidence: 99%
“…Metabolic profiling of F. microcarpa using LC-HR-ESI-MS (Abdelhameed et al 2020) annotated nine phenolic compounds (Figure S1, Table S1) using coupling MZmine with some databases such as Metlin and DNP. Dereplication yielded, a flavonoid diglycoside with molecular formula C 27 H 30 O 15 was detected, as there was a mass ion peak at m/z 594.1573 (Figures S2 and S3).…”
Section: Metabolic Profilingmentioning
confidence: 99%
“…Different parts of F. microcarpa including, the bark, leaves and aerial roots, are known to possess anti-inflammatory, antioxidant, antidiabetic, antimicrobial, antiulcer, antihistamine, and antihyperlipidemic activities (Chiang et al 2005;Kumari and Rani;Taira et al 2005;Ashok et al 2007). In the current study, SARS-CoV-2 main protease inhibition potential; using docking study; was evaluated by testing nine compounds annotated by metabolic profiling (Abdelhameed et al 2020;Elmaidomy et al 2020) from the methanolic extract of F. microcarpa leaves. To the best of our knowledge, this is the first report about the potential of F. microcarpa on COVID-19 virus.…”
Section: Introductionmentioning
confidence: 99%