Thalidomide for the Treatment of Refractory Necrobiosis Lipoidica

Kukreja, Tarun; Petersen, Jeffrey

doi:10.1001/archderm.142.1.20

Cited by 23 publications

(9 citation statements)

References 11 publications

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“…481 Thalidomide, 481 topical PUVA therapy, 482 UVA1 phototherapy, 483 photodynamic therapy, 484 methotrexate, 485 topical granulocyte-macrophage colony-stimulating factor (GM-CSF), 486 and pioglitazone 487 have all been used with some improvement of the disease. It has included topical and intralesional steroids, antiplatelet drugs such as aspirin and ticlopidine, and drugs that decrease blood viscosity such as pentoxifylline.…”

Section: Treatment Of Necrobiosis Lipoidicamentioning

confidence: 99%

The granulomatous reaction pattern

Weedon

2010

Weedon's Skin Pathology

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Section: Treatment Of Necrobiosis Lipoidicamentioning

confidence: 99%

The granulomatous reaction pattern

Weedon

2010

Weedon's Skin Pathology

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“…[42] Thalidomide has anti-TNF effects and has also been reported as a successful therapy. [43] Etanercept too has been used successfully. [44] Topical tacrolimus (0.1%) ointment has been successfully employed in the treatment of early non-ulcerated NLD.…”

Section: Discussionmentioning

confidence: 99%

Necrobiosis lipoidica diabeticorum: A case-based review of literature

Kota¹,

Jammula²,

Kota³

et al. 2012

Indian J Endocr Metab

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Necrobiosis lipoidica diabeticorum (NLD) is a rare chronic and granulomatous skin disorder that affects 0.3% of diabetic patients. Although the etiology and pathogenesis of NLD is still controversial, it is thought that microangiopathy has an important role. The legs are the most common site for NLD, but involvement of other areas such as the abdomen, upper extremities and scalp has been reported. There is no rational therapy. However, benefit has been reported from different treatment regimens such as drugs acting on the hemostatic mechanisms, corticosteroid therapy (topical, intralesional and systemic), enhancers of wound healing, surgery and immunomodulating therapies (including photochemotherapy). We report a 59-year-old female, who was a diabetic patient with multiple, disseminated lesions on the legs, which tended to disappear as the glycemic control was achieved. Hereby, we also review the existing literature for the evolving aspects of etiopathogenesis and treatment.

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“…2 The association of necrobiosis lipoidica with diabetes mellitus is controversial however. In one large series, two-thirds of patients with necrobiosis lipoidica had diabetes.…”

Section: Discussionmentioning

confidence: 99%