Thalidomide prevents rat liver cirrhosis via inhibition of oxidative stress

Chemically Induced Hepatocellular Carcinoma and Stages of Development with Biochemical and Genetic Modulation: A Special Reference to Insulin-Like-Growth Factor II and Raf Gene Signaling

“…During hepatic continual regeneration process, the increased collagen synthesis and deposition result in fibrosis. This alongwith further continual hepatic cell damage due to various stress conditions cause liver cirrhosis (Lv et al, 2006). In cirrhosis, liver morphology alters.…”

Protective effect of <i>Radix Bupleuri</i> extract against liver cirrhosis in rats

“…All of these factors are potential targets for therapy [2]. The inhibition of oxidative stress has been shown to play an important role in preventing the progression of liver cirrhosis [3]. In addition, the degree of liver cirrhosis observed in humans is similar to that observed in diethylnitrosamine (DEN)-induced rats [4,5].…”

Effect of <i>Salvia miltiorrhiza</i> Bge extract on liver cirrhosis in rats

“…Liver cirrhosis is the seventh leading cause of disease-related death in the United States [4]. Liver fibrosis was considered to be a passive and irreversible process due to the collapse of the hepatic parenchyma and its substitution with ECM components [5]. However, the reversibility of liver fibrosis has now been demonstrated both in patients and animal models [6].…”

“…As S. miltiorrhiza is used in traditional Chinese medicine to prevent liver cirrhosis [13], the current study was conducted to evaluate the anti-cirrhosis effects of the herb in rats. A diethylnitrosamine (DEN)-induced liver cirrhosis rat model was used, as this model closely resembles the cirrhosis observed in humans [5,6].…”