Thalidomide treatment of relapsed multiple myeloma patients and changes in circulating VEGF and bFGF

Pitini, Vincenzo; Teti, Diana; Arrigo, Carmela; Aloi, G; Righi, Maria

doi:10.1046/j.1365-2141.2002.37694.x

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“…In addition, a direct relationship between VEGF production and leukemic blasts and malignant plasma cells proliferation has been established, thus anti-VEGF agents are being evaluated in many protocols. The anti-angiogenic activity of the drug may be due to a reduction of both VEGF and b-FGF (basic fibroblast growth factor) levels, although disconcordant findings have been reported [1]. Thalidomide was shown to be effective in relapsed or refractory multiple myeloma and its role as part of the initial treatment armamentarium is under investigation.…”

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confidence: 99%