Thallium-induced testicular toxicity in the rat

Remedial investigation report on the Melton Valley watershed at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Volume 3: Appendix C

“…All rats fed a daily dose of 0.45 mg TYkg died after 4 months . Rats exposed to 10 mg/L T1 in drinking water for 2 mo accumulated TI in testis and exhibited signs of testicular toxicity including reduced sperm motility (Formigli et al, 1986).…”

White Oak Creek Watershed: Melton Valley Area Remedial Investigation Report, Oak Ridge National Laboratory, Oak Ridge, Tennessee: Volume 3 Appendix C

“…All rats fed a daily dose of 0.45 mg TVkg died after 4 months . Rats exposed to 10 m a TI in drinking water for 2 mo accumulated TI in testis and exhibited signs of testicular toxicity including reduced sperm motility (Formigli et al, 1986).…”

Preliminary assessment of the ecological risks to wide-ranging wildlife species on the Oak Ridge Reservation

“…The short-tailed shrew NOAEL and LOAEL are based on a study in which rats were fed thallium sulfate for 60 days (Formigli et al 1986). This study represents subchronic exposures since the duration of the study did not include a critical life stage.…”

“…To estimate the chronic NOAEL, the chronic LOAEL was multiplied by a LOAELNOAEL uncertainty factor of 0.1. Based on the results of Formigli et al (1986), short-tailed shrews experiencing exposures L the LOAEL may display impaired reproduction from a reduction of sperm motility.…”

“…All rats fed a daily dose of 0.45 mg Tl/kg died after 4 months (Kazantzis 1979). Rats exposed to 10 ppm T1 in drinking water for 2 mo accumulated T1 in testis and exhibited signs of testicular toxicity including reduced sperm motility (Formigli et al 1986). Bean and Hudson (1976) orally dosed 3 golden eagles with 60 and 120 mg T12S04/kg bw; the bird receiving 60 mg T12S04/kg survived while the two dosed with 120 mg Tl2SO4/kg died, suggesting an LD,, between the doses.…”