“Thanatosomes”: A unifying morphogenetic concept for tumor hyaline globules related to apoptosis

Papadimitriou, John C.; Drachenberg, Cinthia B.; Brenner, David S.; Newkirk, Carnell; Trump, Benjamin F.; Silverberg, Steven G.

doi:10.1053/hupa.2000.20376

Cited by 76 publications

(89 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These hyaline droplets have been described by Szarek et al (2000) and by Jiraungkoorskul et al (2003) in others fishes exposed to Roundup ® . The hyaline droplets may represent alterations in the protein metabolism and synthesis (Papadimitriou et al 2000, Jiraungkoorskul et al 2003 due to failures in the transcription process caused by Roundup ® (Marc et al 2005). Failures in transcription and protein synthesis could be related to lipidic changes of greater severity found in Roundup ® -exposed fish due to alterations in lipoprotein synthesis necessary for the release and transport of lipids from the hepatocytes (Jones et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Acute toxicity and histopathological alterations of Roundup® herbicide on "cachama blanca" (Piaractus brachypomus)

2008

View full text Add to dashboard Cite

Acute toxicity of the glyphosate -N (phosphonomethyl) glycine- herbicide, Roundup®, in juveniles of cachama blanca, (Piaractus brachypomus), was evaluated and the histopathological lesions were assessed. The 96 h lethal concentration 50 was 97.47mg.L-1 (P<0.05). In the gill, necrotic and proliferative lesions were detected. In the liver, congestion, degenerative foci, hyaline droplets and lipidic vacuolization of the hepatocytes were observed. In the stomach mild hyperplasia of mucous cells was detected, which was also observed in the skin. In this latter tissue, a large increase in the thickness of the epidermis with necrotic lesions, infiltration of leukocytes and melanin pigment were observed. In the brain, degenerative foci of neuronal bodies in the telencephalon associated with gliosis and infiltration of eosinophilic granule cells/mast cells were shown. In conclusion, gills, liver, skin and brain are susceptible to Roundup®. Moreover, effects on the central nervous system could affect olfaction as well as individual and group behavior, the reproductive performance of the fish and hence have repercussions at the population level.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute toxicity and histopathological alterations of Roundup® herbicide on "cachama blanca" (Piaractus brachypomus)

2008

View full text Add to dashboard Cite

show abstract

“…The large bizarre cells and the excess of hyaline globules were such a constant finding as to act as a histologic tumor marker, very likely related to the germline p53 mutation. Hyaline globules are related to apoptosis and cell death, 15 a phenomenon in which p53 plays an important function. In childhood malignant adrenocortical tumor where a similar mutation occurs in the same dimerization domain of TP53, it is believed that an altered apoptotic function may be responsible for tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

Multifocal intrafollicular granulosa cell tumor of the ovary associated with an unusual germline p53 mutation

et al. 2004

View full text Add to dashboard Cite

A 23-year-old woman presented with a 7 cm right multicystic mass in the ovary, which corresponded microscopically to an unusual lesion consisting of a multifocal granulosa cell tumor with intrafollicular ('in situ') growth involving two-thirds of mature follicles. Stromal invasion was found in only one area where neoplastic follicles coalesced. Granulosa cells had atypical, bizarre TP53 positive nuclei with hyperchromatism, abundant mitoses and numerous hyaline globules. The contralateral ovary was normal. From the age of 10 years, the patient had a complex medical history of multiple tumors, including telangiectatic osteosarcoma, typical and malignant phyllodes tumor, reticulohistiocytoma of skin, carcinomas of the breast and lipo-and leiomyosarcoma. The female genital tract also harbored myometrial leiomyomas and an early endometrial carcinoma. Retrospective histologic study of all mesenchymal neoplasms in this patient showed, the conspicuous presence of similar bizarre TP53 positive cells with hyaline globules in all the mesenchymal neoplasms. In the genetic study, a germline p53 gene mutation was detected in exon 10, codon 336, generating a stop codon in the oligomerization domain of the protein (E336X). A further p53 mutation was found in exon 7 in the granulosa cell tumor. Mutation occurred de novo since there was no history of tumors in any family members, all of whom had a wild-type p53. Although this patient shows a typical tumor phenotype of Li Fraumeni syndrome, the germline mutation corresponded to a highly unusual mutated domain, which is similar to the one found in childhood malignant adrenocortical tumor; also a rare neoplasm that originates in adrenocortical cells; which are closely related, both functionally and embryologically, to granulosa cells.

show abstract

“…They have microscopic and morphologic features such as apoptotic nuclear fragments, cytoplasmic blebbing, and plasma protein infiltration that reflect stages of cell injury. 6 In this case of PRCC, the exact nature of the hyaline material is unclear and perhaps simply represents an unusual appearance of the loose myxoid matrix often found in RCCs. Adenoid cystic-like hyaline structures have been described previously in papillary thyroid 7 and metastatic thymic carcinoma.…”

mentioning

confidence: 90%

Papillary renal cell carcinoma with “hyaline globules” simulating adenoid cystic carcinoma

Eluri

Ali

2010

Diagnostic Cytopathology

View full text Add to dashboard Cite

A 59-year-old man with a history of papillary renal cell carcinoma (status-post nephrectomy), HIV infection, and Hepatitis C presented with a right humerus fracture. On physical exam, he was found to have a ''ping-pong ball'' sized swelling in the left supraclavicular region with massive, bilateral cervical and axillary lymphadenopathy. CT scan confirmed significant chest and abdominal adenopathy, compression of major neurovascular bundles and airway by cervical adenopathy, and bilateral lung lesions. There were no lesions in the area of his right radical nephrectomy performed 1 year ago for papillary renal cell carcinoma (PRCC). Pathology of the resected lesion at that time revealed a 4 cm, Fuhrman grade III carcinoma extending into the renal pelvis. Margins were uninvolved and there was no evidence of metastatic disease.Fine needle aspiration (FNA), of one of the enlarged lymph nodes in the left neck was performed using a 25-gauge needle. Smears were either air-dried or alcoholfixed and stained with Diff-Quik and Papanicolaou stains, respectively. Cytomorphology was characterized by hypercellular smears composed of highly unusual, eyecatching, well-defined globoid structures surrounded by a uniform population of malignant cells (Fig. C-1). These globoid structures had a bright magenta or metachromatic appearance on Diff-Quik stain and were highly reminiscent of adenoid cystic carcinoma, especially when surrounded by epithelial cells with a vague basaloid appearance ( Fig. C-2). However, the presence of fine cytoplasmic vacuoles provided evidence that these cells were in fact not basaloid in origin. The hyaline globules appeared pale green and translucent on Papanicolaou stain surrounded by hyperchromatic and crowded malignant cells (Fig. C-3). The hyaline globular material was exclusively extracellular and none of the malignant cells showed intracytoplasmic inclusions. Location of this lesion in the neck did raise the possibility of a salivary gland adenoid cystic carcinoma; however, some of the other smears had true papillary fragments with finely vacuolated neoplastic epithelial cells, abundant macrophages, and other features consistent with metastasis from patient's known PRCC.Papillary renal cell carcinoma (PRCC) comprises from 7 to 15% of all renal cell carcinomas and more commonly presents in women. It has a distinct clinical and pathologic presentation that can separate it from low-grade transitional cell carcinoma, metastatic adenocarcinoma, and Wilms' tumor.1 PRCC can present with a variety of cytological features such as the presence of psammoma bodies, cytoplasmic vacuoles, hyperchromasia, and nuclear grooves.2 However, smooth bordered papillary fragments with fibrovascular cores, lipid-laden foamy macrophages, and intracytoplasmic hemosiderin have been found to be most sensitive for the diagnosis of PRCC.3 Along with cytology, immunoreactivity to CK7 4 and a characteristic cystic, necrotic radiographic finding are useful diagnostic tools.

show abstract

“Thanatosomes”: A unifying morphogenetic concept for tumor hyaline globules related to apoptosis

Cited by 76 publications

References 46 publications

Acute toxicity and histopathological alterations of Roundup® herbicide on "cachama blanca" (Piaractus brachypomus)

Acute toxicity and histopathological alterations of Roundup® herbicide on "cachama blanca" (Piaractus brachypomus)

Multifocal intrafollicular granulosa cell tumor of the ovary associated with an unusual germline p53 mutation

Papillary renal cell carcinoma with “hyaline globules” simulating adenoid cystic carcinoma

Contact Info

Product

Resources

About