That Which Bends Up: A Case Report and Literature Review of Chikungunya Virus

Peper, Shana M.; Monson, Benjamin; Schooneveld, Trevor Van; Smith, Christopher J.

doi:10.1007/s11606-015-3459-3

Cited by 17 publications

(18 citation statements)

References 20 publications

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“…[ 7 ] It was first identified in Tanzania in 1953[ 8 ], and the name comes from a Makonde word that means “that which bends up” due to the position taken by patients suffering from the severe joint pain. [ 9 , 10 ] Since then, it has caused outbreaks in Africa[ 5 , 11 , 12 ], Indian Ocean islands, South East Asia [ 13 – 15 ], Central and South America[ 16 – 18 ], US territories[ 19 ] and Europe. [ 20 – 23 ] CHIKV has now been identified in 94 countries worldwide.…”

Section: Introductionmentioning

confidence: 99%

Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis

Contopoulos‐Ioannidis

Newman-Lindsay

Chow

et al. 2018

PLoS Negl Trop Dis

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BackgroundChikungunya virus (CHIKV) is an emerging arboviral infection with a global distribution and may cause fetal and neonatal infections after maternal CHIKV-infections during gestation.MethodologyWe performed a systematic review to evaluate the risk for: a) mother-to-child transmission (MTCT), b) antepartum fetal deaths (APFD), c) symptomatic neonatal disease, and d) neonatal deaths from maternal CHIKV-infections during gestation. We also recorded the neonatal clinical manifestations after such maternal infections (qualitative data synthesis). We searched PubMed (last search 3/2017) for articles, of any study design, with any of the above outcomes. We calculated the overall risk of MTCT, APFDs and risk of symptomatic neonatal disease by simple pooling. For endpoints with ≥5 events in more than one study, we also synthesized the data by random-effect-model (REM) meta-analysis.Principal findingsAmong 563 identified articles, 13 articles from 8 cohorts were included in the quantitative data synthesis and 33 articles in the qualitative data synthesis. Most cohorts reported data only on symptomatic rather than on all neonatal infections. By extrapolation also of these data, the overall pooled-MTCT-risk across cohorts was at least 15.5% (206/1331), (12.6% by REMs). The pooled APFD-risk was 1.7% (20/1203); while the risk of CHIKV-confirmed-APFDs was 0.3% (3/1203). Overall, the pooled-risk of symptomatic neonatal disease was 15.3% (203/1331), (11.9% by REMs). The pooled risk of symptomatic disease was 50.0% (23/46) among intrapartum vs 0% (0/712) among antepartum/peripartum maternal infections. Infected newborns, from maternal infections during gestation were either asymptomatic or presented within their first week of life, but not at birth, with fever, irritability, hyperalgesia, diffuse limb edema, rashes and occasionally sepsis-like illness and meningoencephalitis. The pooled-risk of neonatal death was 0.6% (5/832) among maternal infections and 2.8% (5/182) among neonatal infections; long-term neurodevelopmental delays occurred in 50% of symptomatic neonatal infections.Conclusions/SignificancePublished cohorts with data on the risk to the fetus and/or newborn from maternal CHIKV-infections during gestation were sparse compared to the number of recently reported CHIKV-infection outbreaks worldwide; however perinatal infections do occur, at high rates during intrapartum period, and can be related to neonatal death and long-term disabilities.

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Section: Introductionmentioning

confidence: 99%

Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis

Contopoulos‐Ioannidis

Newman-Lindsay

Chow

et al. 2018

PLoS Negl Trop Dis

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“…5 Differential diagnoses often include dengue virus, which carries similar symptoms (see Figure 1) and is transmitted by the Aedes mosquito in similar locations. 10 Additionally, chronic arthralgia may mimic rheumatologic conditions including rheumatoid arthritis, underscoring the need a comprehensive history upon initial presentation. 10 Although malaria is still the most common cause of fever in travellers returning to Canada, a broader spectrum of other vector-borne and viral infections are being detected over time including measles, CHIKV and dengue virus.…”

Section: Description Of Chikv: Pathogenesis and Epidemiologymentioning

confidence: 99%

“…10 Additionally, chronic arthralgia may mimic rheumatologic conditions including rheumatoid arthritis, underscoring the need a comprehensive history upon initial presentation. 10 Although malaria is still the most common cause of fever in travellers returning to Canada, a broader spectrum of other vector-borne and viral infections are being detected over time including measles, CHIKV and dengue virus. 11 Since early 2014 and the initial transmission of the CHIKV to the Caribbean islands, a dramatic increase in CHIKV cases diagnosed in Canada has been seen, emphasizing the need for increased awareness and education for Canadian clinicians and healthcare providers.…”

Section: Description Of Chikv: Pathogenesis and Epidemiologymentioning

confidence: 99%

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Chikungunya virus in Canada

Bami¹,

Elzinga²

2017

UWOMJ

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This article presents a previously reported case involving the first Canadian patient to acquire Chikungunya virus (CHIKV) infection after travelling to a newly endemic region in the Americas. The specific history and clinical presentation of this patient is examined, including the treatment and complete resolution of the patient’s symptoms. A brief overview of the general disease course and diagnosis of CHIKV is provided. This case emphasizes the importance of global health education in Canadian medical curricula. The current standards of global health education in Canadian medical schools are briefly reviewed and recommendations based on expert opinions are provided. Although such programs exist, their implementation was found to be variable between schools and increased attention and standardization is currently required.

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“…Chikungunya is the name derived from a work in non-famous language ‘Kimakonde’. It means “to bend out of shape”, explains the appearance of people suffering from polyarthralgia because of chikungunya virus (CHIKV) fever [ 1 ]. It is suspected clinically on symptoms of fever and severe polyarthralgia.…”

Section: Introductionmentioning

confidence: 99%