Thaumatin and gum arabic allergy in chewing gum factory workers

Tschannen, Mattias P.; Glück, Ulrich; Bircher, Andreas J.; Heijnen, Ingmar; Pletscher, Claudia

doi:10.1002/ajim.22729

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…Owing to lack of toxicity, its ADI is still to be established [110]. There is, however, a risk of allergic reactions [111]. The metabolism of thaumatin is similar to that of any other protein in human diet.…”

Section: Proteinsmentioning

confidence: 99%

Natural Sweeteners: The Relevance of Food Naturalness for Consumers, Food Security Aspects, Sustainability and Health Impacts

Saraiva

Carrascosa

Raheem

et al. 2020

IJERPH

127

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At a moment when the population is increasingly aware and involved in what it eats, both consumers and the food sector are showing more interest in natural foods. This review work discusses, addresses and provides details of the most important aspects of consumer’s perceptions of and attitudes to natural foods and in-depth research into natural sweeteners. It also includes issues about their use and development as regards health impacts, food security and sustainability. In line with our main research outcome, we can assume that consumers are very keen on choosing foods with clean labelling, natural ingredients, preferably with other functional properties, without the loss of taste. In response to such a phenomenon, the food industry offers consumers alternative natural sweeteners with the advantage of added health benefits. It is noteworthy that Nature is a superb source of desirable substances, and many have a sweet taste, and many still need to be studied. Finally, we must stress that being natural does not necessarily guarantee market success.

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Section: Proteinsmentioning

confidence: 99%

Natural Sweeteners: The Relevance of Food Naturalness for Consumers, Food Security Aspects, Sustainability and Health Impacts

Saraiva

Carrascosa

Raheem

et al. 2020

IJERPH

127

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show abstract

“…The harmful concentration of AqGP observed was approximately four times higher than the active one, demonstrating a comfortable safety margin between the active and harmful doses of the molecules. Despite the possible allergenic epitope in thaumatin, these results indicate that using the extract in question is safe in practice [31,32]. Evaluation of the anti-nociceptive response was performed using formalin and contortion tests [33].…”

Section: Resultsmentioning

confidence: 99%

Identification of the Active Principle Conferring Anti-Inflammatory and Antinociceptive Properties in Bamboo Plant

et al. 2021

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Early plants began colonizing earth about 450 million years ago. During the process of coevolution, their metabolic cellular pathways produced a myriad of natural chemicals, many of which remain uncharacterized biologically. Popular preparations containing some of these molecules have been used medicinally for thousands of years. In Brazilian folk medicine, plant extracts from the bamboo plant Guadua paniculata Munro have been used for the treatment of infections and pain. However, the chemical basis of these therapeutic effects has not yet been identified. Here, we performed protein biochemistry and downstream pharmacological assays to determine the mechanisms underlying the anti-inflammatory and antinociceptive effects of an aqueous extract of the G. paniculata rhizome, which we termed AqGP. The anti-inflammatory and antinociceptive effects of AqGP were assessed in mice. We identified and purified a protein (AgGP), with an amino acid sequence similar to that of thaumatins (~20 kDa), capable of repressing inflammation through downregulation of neutrophil recruitment and of decreasing hyperalgesia in mice. In conclusion, we have identified the molecule and the molecular mechanism responsible for the anti-inflammatory and antinociceptive properties of a plant commonly used in Brazilian folk medicine.

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“…The ELS search carried out by the applicant identified a publication on potential respiratory allergenic potential of thaumatin in workers (Tschannen et al., 2017 ). The same study has been recently assessed by the FAF Panel (EFSA FAF Panel, 2021 ).…”

Section: Assessmentmentioning

confidence: 99%

Assessment of the feed additive consisting of thaumatin for all animal species for the renewal of its authorisation (ADISSEO France S.A.S.)

Bampidis¹,

Azimonti²,

Bastos³

et al. 2023

EFS2

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Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for the renewal of authorisation of thaumatin as a sensory additive (flavouring compound) for all animal species. The applicant requested a change in the authorising regulation for the minimum content of nitrogen and protein in the specification of the additive. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) confirms that the use of thaumatin under the current authorised conditions of use is safe for the target species, the consumers and the environment. This conclusion can be extended to the newly proposed specification. Due to its proteinaceous nature, the additive is considered to be a respiratory sensitiser. Thaumatin is not irritant to the eyes and the skin. In the absence of data, no conclusion on skin sensitisation could be made. The proposed modification of the specification of the additive is not considered to have an impact on the efficacy of thaumatin.

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Thaumatin and gum arabic allergy in chewing gum factory workers

Cited by 9 publications

References 15 publications

Natural Sweeteners: The Relevance of Food Naturalness for Consumers, Food Security Aspects, Sustainability and Health Impacts

Natural Sweeteners: The Relevance of Food Naturalness for Consumers, Food Security Aspects, Sustainability and Health Impacts

Identification of the Active Principle Conferring Anti-Inflammatory and Antinociceptive Properties in Bamboo Plant

Assessment of the feed additive consisting of thaumatin for all animal species for the renewal of its authorisation (ADISSEO France S.A.S.)

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