Thawed solvent/detergent‐treated plasma demonstrates comparable clinical efficacy to thawed plasma

Abstract

Background Thawed Plasma (TP), plasma thawed and refrigerated for up to 5 days, is a commonly transfused plasma product. This pilot study was conducted to determine whether Thawed Solvent/Detergent‐treated Plasma stored refrigerated for up to 5‐days post‐thaw (T‐S/D) was as efficacious as TP. Study Design and Methods This single institution retrospective cohort analysis evaluated the efficacy of T‐S/D in reversing coagulopathies in comparison to TP. Utilizing the institution's electronic medical records, transfusion data were collected in adult patients who received either TP or T‐S/D. The primary outcome was the incidence of subsequent transfusions within 24 hours after first dose of either type of plasma. Secondary outcomes included the number of blood products transfused within 24 hours of first‐dose plasma, correction of pre‐transfusion coagulation laboratory values, volume transfused, and clinical outcomes. Results TP was received by 301 patients and 137 received T‐S/D during the first 32 months post‐implementation of T‐S/D. There was no difference in incidence of subsequent transfusions or number of blood products given. The median pre‐INR of both the TP and T‐S/D cohorts was 1.9, with a similar decrease in INR of 0.2 and 0.3 (p = 0.36), respectively, post plasma transfusion. There was no difference in correction of PT/aPTT, mortality, transfusion reactions, readmission rates, length of stay, or inpatient deep venous thrombosis. The median volume of T‐S/D plasma transfused for the first dose was 126 mL less than TP (p = .0001). Conclusion T‐S/D was as efficacious as TP for the treatment of coagulopathies and the reversal of coagulation laboratory values.

Thirty years of experience with solvent/detergent‐treated plasma for transfusion medicine

“…There was no difference in mortality, transfusion reactions, readmission rates, length of stay in hospital, and deep venous thrombosis (DVT) incidence between blood products. 56 Mean total dose of octaplasLG (0.52 units [±1.43]) was comparable with that of TP (0.64 units [±1.74]). However, the standardized volume of octaplasLG resulted in a lower transfusion volume required to reverse coagulopathies to the same extent as the higher TP volume, with 126 mL less thawed octaplasLG transfused versus thawed and refrigerated TP ( p = .0001), which could be beneficial for patients at risk of TACO.…”

“…OctaplasLG is currently supplied frozen, and the thawed product is stable during refrigerated storage for ≤5 days. 21,56 However, there is increasing interest in freeze-dried plasma (FDP). 93 Recently, a new freeze-dried form of octaplasLG, octaplasLG powder and solvent for solution for infusion, which upon reconstitution has identical biochemical quality to octaplasLG, 94 has been registered in 17 European countries.…”

Evaluation of solvent/detergent‐treated plasma safety and efficacy in orthotopic liver transplant and thrombotic thrombocytopenic purpura patients: A single center experience

“…There have been several studies evaluating the clinical efficacy of SDP, although the majority have involved relatively few patients and span a broad range of clinical settings 23–33 . Four of these were prospective studies in which patients were randomized to either FFP or SDP, and all showed no significant clinical differences after transfusion of either plasma product 27–30 .…”

“…There have been several studies evaluating the clinical efficacy of SDP, although the majority have involved relatively few patients and span a broad range of clinical settings. [23][24][25][26][27][28][29][30][31][32][33] Four of these were prospective studies in which patients were randomized to either FFP or SDP, and all showed no significant clinical differences after transfusion of either plasma product. [27][28][29][30] Five were prospective, observational studies with 8, 24 30, 23 63, 25 67, 31 and 164 26 patients enrolled; these studies again found that SDP was clinically effective, and no significant differences between FFP and SDP were detected.…”

A comprehensive review of the principles, key factors, application, and assessment of thawing technologies for muscle foods

“…Racine‐Brzostek et al. (2020) reported that the high temperature generated by MT could exacerbate protein aggregation and denaturation, resulting in higher cooking losses. Similarly, Sun et al.…”