1987
DOI: 10.1007/bf00364276
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The ?1 and ?2 domains of H-2 class I molecules interact to form unique epitopes

Abstract: Mouse class I antigens are the major targets of cytolytic T lymphocytes in both major histocompatibility complex (MHC)-restricted and allogeneic responses. Considerable evidence has recently accumulated demonstrating that MHC class I molecules encoded by genes whose alpha 1 and alpha 2 coding exons were interchanged are not recognized by T lymphocytes specific for parental class I products. Along with the loss of T-cell reactivity, there is a loss of recognition by some, but not all monoclonal antibodies. In t… Show more

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Cited by 5 publications
(3 citation statements)
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“…RIA of transfected cells was performed as described (11). The three H-2DP-specific monoclonal antibodies (mAb; 135,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)3) used in this study have been described (21,22 Fig. 2.…”
mentioning
confidence: 99%
“…RIA of transfected cells was performed as described (11). The three H-2DP-specific monoclonal antibodies (mAb; 135,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)3) used in this study have been described (21,22 Fig. 2.…”
mentioning
confidence: 99%
“…Kanda et al by recombination between the LP and Dd genes for expression of antibody-defined epitopes (Darsley et al, 1987;Kanda et al, 1987). Kanda et al by recombination between the LP and Dd genes for expression of antibody-defined epitopes (Darsley et al, 1987;Kanda et al, 1987).…”
mentioning
confidence: 99%
“…T. Kanda et al by recombination between the LP and Dd genes for expression of antibody-defined epitopes (Darsley et al, 1987;Kanda et al, 1987). Comparison of these exon-shuffled genes with those of Dd and Ld allowed us to implicate particular amino acid residues in the formation of specific serological epitopes.…”
mentioning
confidence: 99%