The 1-minute sit-to-stand test to detect desaturation during 6-minute walk test in interstitial lung disease

Oishi, Keiji; Matsunaga, Kazuto; Asami‐Noyama, Maki; Yamamoto, Tasuku; Hisamoto, Yukari; Fujii, Tetsuya; Harada, Mikihiko; Suizu, Junki; Murakawa, Keita; Chikumoto, Ayumi; Matsuda, Kazuki; Kanesada, Haruka; Kikuchi, Yujiro; Hamada, Kazuki; Uehara, Sho; Suetake, Ryo; Ohata, Syuichiro; Murata, Yoriyuki; Yamaji, Yoshikazu; Sakamoto, Kenji; Ito, Kosuke; Osoreda, Hisayuki; Edakuni, Nobutaka; Kakugawa, Tomoyuki; Hirano, Tsunahiko; Yano, Masafumi

doi:10.1038/s41533-022-00268-w

Cited by 17 publications

(8 citation statements)

References 45 publications

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“…This difference could be due to variations in the body stature as well as due to difference in the extent of ILD in the mentioned studies. On the other hand, number of repetitions in 1-STST was comparable to previous studies ( Oishi et al, 2022 ; Briand et al, 2018 ; Tremblay Labrecque et al, 2020 ). On comparing, a moderate degree of correlation ( r =0.48, P <0.001) was seen between 6MWD and number of 1-STST repetitions.…”

Section: Discussionsupporting

confidence: 89%

“…Fifty-six subjects (93.3%) were consistently grouped by both 6MWT and 1-STST based on oxygen desaturation of ≥4% or less, (κ=0.56; 95% CI, 0.30-0.82). Previous studies also showed a similar trend but with a higher degree of agreement (0.68-0.82) (Briand et al, 2018;Oishi et al, 2022;Tremblay Labrecque et al, 2020). The above results strongly suggest that both 6MWT and 1-STST are equally reliable in detecting changes in SpO2 in ILD patients.…”

Section: Discussionsupporting

confidence: 75%

“…The available evidence supports its use as a valuable alternative to 6MWT in COPD patients ( Ozalevli et al, 2007 ; Reychler et al, 2018 ). However, studies on the use of 1-STST in ILD has been sparse with a few showing positive correlation between 1-STST and 6MWT in terms of lowest (nadir) peripheral oxygen saturation (SpO 2 ) ( Briand et al, 2018 ; Oishi et al, 2022 ). However, the results have not been uniform, with a lack of collective evaluation of all the common variables.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the feasibility of 1-min sit-to-stand test in evaluating functional exercise capacity in interstitial lung disease patients

Singh,

Aggarwal,

Dutta

et al. 2023

J Exerc Rehabil

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Six-min walk test (6MWT) is widely used exercise test for the evaluation of interstitial lung disease (ILD). However, the long test duration and need for long and flat surface hinder its routine use. One-min sit-to-stand test (1-STST) is devoid of such limitations, but has been scarcely evaluated. The study was conducted to evaluate the performance of 1-STST by correlating it with 6MWT in ILD patients. Stable ILD patients were prospectively enrolled. After initial spirometry, all patients performed 6MWT and 1-STST following the standard recommendations. Exercise capacity and physiological parameters (heart rate, pulse oxygen saturation, blood pressure and dyspnea [modified Borg scale]) including peripheral oxygen saturation (SpO2) were correlated after the tests using Pearson correlation, Intraclass correlation coefficient (ICC) and kappa (κ) coefficient. The results showed that the mean age of the patients (n= 60) was 58.8± 11.5 years (male:female= 1:1). Repetitions after 1-STST showed significant correlation with 6MWT (r = 0.48; P< 0.001). Changes in the physiological variables were similar (P> 0.05) with good consistency (ICC= 0.68–0.95) between 6MWT and 1-STST. Both lowest SpO2 and difference in SpO2 also showed good agreement (ICC= 0.86; 95% confidence interval [CI], 0.77–0.92 and ICC= 0.68; 95% CI, 0.47–0.81 respectively) and significant correlation (r = 0.76 and r= 0.52, respectively). 1-STST and 6MWT were consistent in identifying patients having oxygen desaturation ≥ 4% (κ= 0.56; 96% CI, 0.30–0.82). The results demonstrated that the performance of 1-STST was consistent with 6MWT in terms of exercise capacity and change in physiological parameters. 1-STST can be a valid alternative to 6MWT in the assessment of ILD patients, especially in peripheral health centers.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of the feasibility of 1-min sit-to-stand test in evaluating functional exercise capacity in interstitial lung disease patients

Singh,

Aggarwal,

Dutta

et al. 2023

J Exerc Rehabil

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“…Of late, the 1-min sit-to-stand test (1STS) has gained popularity. Significant correlations were seen between distance walked during 6MWT and number of repetitions on 1STS, as well similarities in maximal oxygen uptake, nadir S pO 2 and frequency of desaturation [38][39][40], suggesting that the 1STS may offer a simpler alternative to the 6MWT, with potential for primary care use. However, responsiveness to acute oxygen administration has not been demonstrated.…”

Section: Introductionmentioning

confidence: 87%

Oxygen in interstitial lung diseases

Cordeiro

Nunes²,

Smith³

et al. 2023

Breathe

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Domiciliary oxygen is essential in the care of hypoxaemic interstitial lung disease (ILD) patients. Guidelines concur in advising prescription of long-term oxygen therapy (LTOT) for ILD patients with severe hypoxaemia at rest, in view of its beneficial impact on breathlessness/disability and extrapolating potential survival benefits seen in COPD patients. A less severe hypoxaemia threshold for initiation of LTOT is recommended for patients with pulmonary hypertension (PH)/right heart failure, requiring careful evaluation in all ILD patients. In light of evidence suggesting a link between nocturnal hypoxaemia, development of PH and poor survival, studies assessing the impact of nocturnal oxygen are urgently needed.Severe exertional hypoxaemia is frequent in ILD patients, with impact on exercise tolerance, quality of life and mortality. Ambulatory oxygen therapy (AOT) has been associated with improvement in breathlessness and quality of life in ILD patients with exertional hypoxaemia. However, given the paucity of evidence, not all current AOT guidelines are in agreement. Ongoing clinical trials will provide further useful data. Despite its beneficial effects, supplemental oxygen imposes burdens and challenges to patients. A key unmet area of need is the development of less cumbersome and more efficient oxygen delivery systems to reduce the negative impact of AOT on patients' lives.

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“…Details of the COVID-19 restrictions throughout the study period are summarised in the e-supplement. Including the 6 min walk test (6MWT) [ 21 ] which was conducted in person or the 1-minute sit-to-stand (STS) conducted remotely [ 22 , 23 ]. For the one-minute STS participants were instructed to use a stable kitchen or dining room chair.…”

Section: Intervention - Pulmonary Rehabilitationmentioning

confidence: 99%

Changes in physical activity in people with idiopathic pulmonary fibrosis before and after virtual pulmonary rehabilitation: a feasibility study

O’Shea,

Murphy,

Fox

et al. 2024

BMC Pulm Med

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Background Pulmonary rehabilitation (PR) is recommended for the treatment of people with idiopathic pulmonary fibrosis (IPF). Physical activity is an important health behaviour, closely linked to survival in people with IPF. Little is known about the impact of virtual (V) PR on physical activity in people with IPF. Objective To explore the feasibility of conducting a trial to explore effect of virtual PR on objectively measured physical activity in people with IPF. Methods All patients with a diagnosis of IPF in a stable phase of the disease were invited to participate in VPR: a 10 week exercise programme delivered twice-weekly for one hour. Data were collected at baseline (BL) and post VPR (10 weeks): Kings Brief Interstitial Lung Disease (K-BILD), Exercise capacity (6-minute walk test (6MWT) or 1-minute sit-to-stand (STS)) and Physical Activity. Physical activity was measured with a triaxial accelerometer for seven days. Screening, recruitment, adherence and safety data were collected. Results 68 people were screened for this study. N = 16 participants were recruited to the study. There was one dropout. N = 15 completed VPR. All results reported in mean (standard deviation) (SD). Participants attended 18.1(2.0) of the 20 sessions. No adverse events were detected. The mean age of participants was 71.5(11.5) years, range: 47–95 years; 7 M:9 F. Mean (SD) FEV1 2.3(0.3)L, FVC 2.8(0.7)L. No statistically significant changes were observed in outcome measures apart from exercise capacity. Light physical activity increased from 152(69.4) minutes per day (n = 16) to 161.9(88.7) minutes per day (n = 14), mean change (SD) (CI) p-value: 9.9 (39.8) [-12.3 to 30.9] p = 0.4. Moderate-to-vigorous physical activity increased from 19.1(18.6) minutes per day (n = 16) to 25.7(28.3) minutes per day (n = 14), mean change (SD) (CI) p-value: 6.7 (15.5) [-2.1 to 15.1] p = 0.1. Step count increased from 3838(2847) steps per day (n = 16) to 4537(3748) steps per day (n = 14), mean change (SD) (CI) p-value: 738 (1916) [-419.3 to 1734.6] p = 0.2. K-BILD (n = 15) increased from 55.1(7.4) at BL to 55.7(7.9) post VPR mean change (SD) [95% confidence interval] (CI) p-value: 1.7(6.5) [-1.7 to 5.3], p = 0.3. 6MWT (n = 5) increased from 361.5(127.1) to 452.2(136.1) meters, mean change (SD) (CI) p-value: 63.7 (48.2) [-3.8 to 123.6], p = 0.04 and 1-minute STS increased from 17.6(3.0) (n = 11) to 23.7(6.3) (n = 10), mean change (SD) (CI) p-value 5.8 (4.6) [2.6 to 9.1], p = 0.003. Conclusion VPR can improve physical activity in people with IPF. A number of important feasibility issues included recruitment, retention, adherence and safety have been reported which are crucial for future research in this area. A fully powered trial is needed to determine the response of people with IPF to PR with regard to physical activity.

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The 1-minute sit-to-stand test to detect desaturation during 6-minute walk test in interstitial lung disease

Cited by 17 publications

References 45 publications

Assessment of the feasibility of 1-min sit-to-stand test in evaluating functional exercise capacity in interstitial lung disease patients

Assessment of the feasibility of 1-min sit-to-stand test in evaluating functional exercise capacity in interstitial lung disease patients

Oxygen in interstitial lung diseases

Changes in physical activity in people with idiopathic pulmonary fibrosis before and after virtual pulmonary rehabilitation: a feasibility study

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