The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description

Holstege, Henne; Beker, Nina; Dijkstra, Tjitske; Pieterse, Karlijn; Wemmenhove, Elizabeth; Schouten, Kimja; Thiessens, Linette; Horsten, Debbie; Rechtuijt, Sterre; Sikkes, Sietske A.M.; Poppel, F.W.A. van; Meijers-Heijboer, Hanne; Hulsman, Marc; Scheltens, Philip

doi:10.1101/295287

Cited by 13 publications

(25 citation statements)

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“…The value of using the clinical impression of the study researcher as a selection criterion was evidenced by previous results of the 100‐plus Study. Centenarians who were estimated to be cognitively impaired by the study researcher had significantly lower test scores compared to those who were regarded cognitively healthy …”

Section: Discussionmentioning

confidence: 99%

“…Participants were recruited by searching different types of (online) media that mention centenarians and by mouth‐to‐mouth advertisement. A further description of inclusion and recruitment procedures can be found elsewhere . This study was approved by the Medical Ethics Committee, and all participants provided informed consent.…”

Section: Methodsmentioning

confidence: 99%

“…A further description of inclusion and recruitment procedures can be found elsewhere. 20 This study was approved by the Medical Ethics Committee, and all participants provided informed consent.…”

Section: Populationmentioning

confidence: 99%

“…Here, we aim to generate robust normative data for the evaluation of cognitive functioning in centenarians, while considering sensory impairments. For this, we used a large sample of cognitively healthy centenarians from the Dutch 100‐plus Study …”

mentioning

confidence: 99%

“…For this, we used a large sample of cognitively healthy centenarians from the Dutch 100-plus Study. 20…”

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confidence: 99%

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Neuropsychological Test Performance of Cognitively Healthy Centenarians: Normative Data From the Dutch 100‐Plus Study

Beker

Sikkes

Hulsman

et al. 2018

J American Geriatrics Society

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Objectives The fraction of the population that reaches the age of 100 years is growing. At this age, dementia incidence is high and cognitive functioning is highly variable across individuals. Normative data for neuropsychological tests are lacking in centenarians, which hampers the ability to evaluate their cognitive functioning for both research and clinical practice. Here, we generated norms for neuropsychological tests in a sample of cognitively healthy centenarians while taking sensory impairments into account. Design Cross‐sectional cohort study. Setting Centenarians who participate in the prospective 100‐plus Study. Participants A total of 235 centenarians (71.5% female), who self‐reported to be cognitively healthy, which was confirmed by an informant and a trained researcher. Measurements We generated normative data for 15 cognitive tests, measuring global cognition (Mini‐Mental State Examination [MMSE]), premorbid intelligence, attention, language, memory, executive function, and visuospatial function by multiple linear regressions and/or by reporting percentiles. Results Normative data for global cognition resulted in a mean MMSE score of 25.6 ± 3.1 (range = 17‐30; interquartile range = 24‐28). Vision problems and fatigue often complicated the ability to complete tests, and these problems explained 41% and 22% of the missing test scores, respectively. In contrast, hearing problems (4%) and task incomprehension (6%) rarely complicated test performance. While educational level was associated with performance on the majority of the tests, sex and age were only weakly associated with test performance. Conclusions We generated normative data for 15 common neuropsychological tests in a large sample of cognitively healthy centenarians, while taking age‐related sensory impairments into consideration. These normative data allow the detection of deficits across a wide range of cognitive domains. Our results suggest that, next to education level, vision ability and the level of fatigue should be taken into account when evaluating cognitive functioning in centenarians. J Am Geriatr Soc 67:759–767, 2019.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Populationmentioning

confidence: 99%

mentioning

confidence: 99%

“…For this, we used a large sample of cognitively healthy centenarians from the Dutch 100-plus Study. 20…”

mentioning

confidence: 99%