The +1059G/C polymorphism in the CRP gene is associated with decreased serum CRP levels and involvement of the terminal ileum in patients with Crohn's disease

Thalmaier, D.; Dambacher, Julia; Seiderer, Julia; Konrad, Astrid; Schachinger, Veronika; Pfennig, Simone; Otte, Jan-Michel; Crispin, Alexander; Göke, B.; Ochsenkühn, Thomas; Brand, Stephan

doi:10.1055/s-2006-955475

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“…For example, gene variants coding for proteins involved in bacterial phagocytosis, leukocyte chemotaxis, or activation of antigen-presenting cells (APCs) have been shown to be *These authors contributed equally to this work. associated with IBD by us and others (4)(5)(6)(7). Recent genomewide scans identified several other CD susceptibility genes including IL23R and ATG16L1 (8)(9)(10).…”

Section: Introductionmentioning

confidence: 86%

“…However, most clinical trials use serum CRP measurements instead of these proinflammatory cytokines for the evaluation of inflammatory disease activity. In addition, we recently showed that certain genetic variants influence serum CRP levels (6). We, therefore, analyzed if this polymorphism also influences the expression of serum CRP, the prototypic acute phase protein, which was adjusted for disease activity using the CDAI defined by Best et al (36), in a subcohort of 111 CD patients for whom corresponding CDAI scores were available.…”

Section: Associations Of the -105g > A Polymorphism With Serum Tnf-amentioning

confidence: 99%

“…Since the identification of CARD15 as the first susceptibility gene for CD (3), there is also increasing evidence for genetic factors contributing to the exaggerated immune response in IBD patients. For example, gene variants coding for proteins involved in bacterial phagocytosis, leukocyte chemotaxis, or activation of antigen‐presenting cells (APCs) have been shown to be associated with IBD by us and others (4–7). Recent genome‐wide scans identified several other CD susceptibility genes including IL23R and ATG16L1 (8–10).…”

Section: Introductionmentioning

confidence: 99%

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The role of the selenoprotein S (SELS) gene −105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation

et al. 2007

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Recently, a -105G>A promoter polymorphism coding for selenoprotein S (SELS) has been shown to increase proinflammatory cytokine expression. We, therefore, analyzed SELS expression and potential phenotypic consequences of the -105G>A polymorphism in patients with inflammatory bowel disease (IBD). SELS mRNA was measured by quantitative polymerase chain reaction (PCR) in intestinal epithelial cells (IEC) after stimulation with proinflammatory cytokines and in human colonic biopsies of IBD patients as well as in murine models of ileitis and murine cytomegalovirus (MCMV) colitis. Genomic DNA from 563 individuals (Crohn's disease: n = 205; ulcerative colitis: n = 154; controls: n = 204) was analyzed for the presence of the SELS-105G>A polymorphism and the three nucleotide-binding oligomerization domain-containing protein 2 (NOD2)/caspase recruitment domain-containing protein 15 (CARD15) variants p.Arg702Trp, p.Gly908Arg and p.Leu1007fsX1008. SELS mRNA expression was increased in IEC after stimulation with proinflammatory cytokines, while its expression was not significantly altered in murine ileitis and MCMV colitis and in inflamed ileal and colonic lesions in IBD patients compared with normal controls. The SELS-105G>A polymorphism was observed with similar frequencies in IBD patients and controls and was not associated with a certain disease phenotype or serum tumor necrosis factor alpha (TNF-alpha) levels in these patients. Medium serum TNF-alpha was 1.27 pg/ml in IBD patients, while none of the controls had TNF-alpha concentrations above the detection threshold (P < 0.0001). SELS mRNA expression is upregulated by proinflammatory cytokines in IECs but the SELS-105G>A polymorphism is not associated with IBD susceptibility and does not contribute to a certain disease phenotype or increased TNF-alpha levels in IBD patients.

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Section: Introductionmentioning

confidence: 86%

Section: Associations Of the -105g > A Polymorphism With Serum Tnf-amentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The role of the selenoprotein S (SELS) gene −105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation

et al. 2007

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The +1059G/C polymorphism in the CRP gene is associated with decreased serum CRP levels and involvement of the terminal ileum in patients with Crohn's disease

Cited by 1 publication

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The role of the selenoprotein S (SELS) gene −105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation

The role of the selenoprotein S (SELS) gene −105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation

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