The 13C urea breath test in the diagnosis of Helicobacter pylori infection

Savarino, Vincenzo; Vigneri, Sergio; Celle, G

doi:10.1136/gut.45.2008.i18

Cited by 161 publications

(126 citation statements)

References 28 publications

(28 reference statements)

Supporting

Mentioning

119

Contrasting

Unclassified

Order By: Relevance

“…Test methods to identify the activity of H. pylori infections such as the urease breath test 11 are very accurate, but there were limitations because this is a retrospective study and the study was conducted using serum antibody tests. The antibody titer becomes positive and remains so for long periods in some cases.…”

Section: Patientsmentioning

confidence: 99%

Influence of Helicobacter pylori on platelets after bone marrow transplantation from unrelated donors

Wakae

Takatsuka

Mori

et al. 2003

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:This study was performed to clarify the influence of Helicobacter pylori on the platelet count in patients undergoing bone marrow transplantation (BMT) from unrelated donors. Of 23 consecutive patients undergoing BMT from unrelated donors, the H. pylori antibody test did not change from before conditioning until recovery of the platelet count in 15 patients. These patients were classified into H. pylori antibody-positive (n ¼ 8) and -negative (n ¼ 7) groups. In the H. pylori antibody-positive group, the platelet count exceeded 20 Â 10 9 /l significantly faster after BMT, than in the H. pylori antibody-negative group. When myelosuppression was most severe, the interleukin-6 (IL-6) level was significantly higher in the positive group than in the negative group (67.0710.6 vs 9.972.4 pg/ml, Po0.05). In addition, the thrombopoietin level was significantly lower in the positive group than in the negative (510.17313.9 vs 3209.172006.7 pg/ml, Po0.01). These data suggest that H. pylori infection accelerates recovery of the platelet count after BMT from unrelated donors, possibly by stimulating IL-6 production.

show abstract

Section: Patientsmentioning

confidence: 99%

Influence of Helicobacter pylori on platelets after bone marrow transplantation from unrelated donors

Wakae

Takatsuka

Mori

et al. 2003

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…Thus the UBT is a highly accurate test, with a sensitivity and specificity of more than 90 % (Lerang et al, 1998;Savarino et al, 1999;Gomez et al, 2002;Perri et al 2002). Ohara et al (2004) reported that a UBT using film-coated [ 13 C]urea tablets resulted in better accuracy compared with a standard UBT in Japanese patients.…”

Section: Resultsmentioning

confidence: 99%

“…A UBT is a useful method for diagnosis of H. pylori, particularly in patients treated with eradication therapy (Metz et al, 1998;Savarino et al, 1999;Riepl et al, 2000;Wu et al, 2006). As bacteria other than H. pylori possess urease activity and colonize the oral cavity and gastric mucosa, false-positive reactions can occur with the UBT.…”

Section: Introductionmentioning

confidence: 99%

Urease-positive bacteria in the stomach induce a false-positive reaction in a urea breath test for diagnosis of Helicobacter pylori infection

Osaki

Mabe

Hanawa

et al. 2008

Journal of Medical Microbiology

110

View full text Add to dashboard Cite

This study investigated the influence of urease-positive non-Helicobacter pylori bacteria on the results of a urea breath test (UBT) to evaluate the diagnostic utility of a UBT using film-coated [ 13 C]urea tablets. The UBT was performed in 102 patients treated with a proton pump inhibitor and antibiotics for the eradication of H. pylori. Urease-producing bacteria other than H. pylori were isolated and identified from the oral cavity and stomach. In 4/102 patients, the UBT gave false-positive results. These false-positive results were found to be caused by the presence of urease-positive bacteria in the oral cavity and stomach. Five bacterial species with urease activity (Proteus mirabilis, Citrobacter freundii, Klebsiella pneumoniae, Enterobacter cloacae and Staphylococcus aureus) were subsequently isolated from the oral cavity and/or stomach. As there was no correlation between the in vitro urease activity of urease-positive non-H. pylori bacteria and the UBT value, and all of the patients with a false-positive UBT result were suffering from atrophic gastritis, it is possible that the false-positive results in the UBT were a result of colonization of urease-positive bacteria and gastric hypochlorhydric conditions. Thus, for the diagnosis of H. pylori infection using a UBT, the influence of stomach bacteria must be considered when interpreting the results.

show abstract

“…E-mail: vsavarin@unige.it of the outcome of eradication therapy. 6 The excellent performance of UBT in the pre-and post-treatment diagnosis of H. pylori infection has been confirmed in many studies, 7 whereas HpSA has been assessed in a smaller number of trials due to its more recent availability. Studies on untreated subjects have indicated that HpSA and UBT provide similar results in the detection of the infection.…”

Section: Introductionmentioning

confidence: 99%

Stool antigen assay (HpSA) is less reliable than urea breath test for post‐treatment diagnosis of Helicobacter pylori infection

Bilardi¹,

Biagini²,

Dulbecco³

et al. 2002

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

The 13C urea breath test in the diagnosis of Helicobacter pylori infection

Cited by 161 publications

References 28 publications

Influence of Helicobacter pylori on platelets after bone marrow transplantation from unrelated donors

Influence of Helicobacter pylori on platelets after bone marrow transplantation from unrelated donors

Urease-positive bacteria in the stomach induce a false-positive reaction in a urea breath test for diagnosis of Helicobacter pylori infection

Stool antigen assay (HpSA) is less reliable than urea breath test for post‐treatment diagnosis of Helicobacter pylori infection

Contact Info

Product

Resources

About