The 13C-Xylose Breath Test for the Diagnosis of Small Bowel Bacterial Overgrowth in Children

Dellert, Susan F.; Nowicki, Michaeł; Farrell, Michael; Delente, Jacques; Heubi, James E.

doi:10.1097/00005176-199708000-00005

Cited by 38 publications

(18 citation statements)

References 11 publications

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“…Aspiration and culture of duodeno-jejunal fluid is considered the gold standard for diagnosing bacterial overgrowth in children [26,27]. Duodeno-jejunal tissue obtained endoscopically or radiologically (insertion of a jejunal tube) can also be cultured.…”

Section: Diagnosis Of Sbbomentioning

confidence: 99%

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Small bowel bacterial overgrowth: A negative factor in gut adaptation in pediatric SBS

Cole¹,

Ziegler²

2007

Curr Gastroenterol Rep

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Small bowel bacterial overgrowth (SBBO) is common in infants and children with short bowel syndrome (SBS). Its occurrence is due to alterations in anatomy, motility, and secretion, which promote the abnormal growth of bacteria. SBBO is associated with significant clinical problems, including prolonged dependence on parenteral nutrition, liver injury, and malabsorption. A major clinical challenge is in making the correct diagnosis of bacterial overgrowth. Management of this disorder is still poorly understood and should be evaluated adequately. This review addresses the current understanding of bacteria in the intestines and issues related to bacterial overgrowth in pediatric SBS.

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Section: Diagnosis Of Sbbomentioning

confidence: 99%

“…The d-xylose breath concentration and urinary choloyl-para-aminobenzoic acid excretion assays were developed as alternative noninvasive methods for diagnosing SBBO [26,27,33]. There are insufficient data on the sensitivity and specificity of these methods for diagnosing SBBO in young children and infants with SBS.…”

Section: Diagnosis Of Sbbomentioning

confidence: 99%

Small bowel bacterial overgrowth: A negative factor in gut adaptation in pediatric SBS

Cole¹,

Ziegler²

2007

Curr Gastroenterol Rep

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“…Isotope breath tests that have been used as alternative means to diagnose SBBO, e. g. using labeled glycocholate [43] or D-xylose [44], were found to be superior to the GHBT. However, most of these substrates were evaluated using radioisotopes, so that the results cannot be compared directly.…”

Section: Discussionmentioning

confidence: 99%

Use of the lactose-[13C]ureide breath test for diagnosis of small bowel bacterial overgrowth: comparison to the glucose hydrogen breath test

et al. 2009

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“…This technique is based on the use of either the radioactive isotope of carbon, 14C or the safer and preferable nonradioactive 13C isotope [33,34] . 13C differs by only one neutron from the naturally more common 12Catom.…”

Section: Principlementioning

confidence: 99%

“…Reportedly Dxylose is a poor metabolic substrate for common coliform bacteria including Esch richia coli, enterococci, and clostridia, increasing the risk of falsenegative results. Due to variation found in literature in sensitivities and specificities in comparison to hydrogen BT its use still remains controversial [34] . Glycocholate BT which is considered the forerunner of BTs for the evaluation of suspected SIBO used glyco cholic acid labeled with 14C [60] .…”

Section: Carbon-breath Tests To Determine Small Intestine Bacterial Omentioning

confidence: 99%

Update on diagnostic value of breath test in gastrointestinal and liver diseases

Siddiqui

Ahmed

Abid

2016

WJGP

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In the field of gastroenterology, breath tests (BTs) are used intermittently as diagnostic tools that allow indirect, non-invasive and relatively less cumbersome evaluation of several disorders by simply quantifying the appearance in exhaled breath of a metabolite of a specific substrate administered. The aim of this review is to have an insight into the principles, methods of analysis and performance parameters of various hydrogen, methane and carbon BTs which are available for diagnosing gastrointestinal disorders such as Helicobacter pylori infection, small intestinal bacterial overgrowth, and carbohydrate malabsorption. Evaluation of gastric emptying is routinely performed by scintigraphy which is however, difficult to perform and not suitable for children and pregnant women, this review has abridged the 13C-octanoic acid test in comparison to scintigraphy and has emphasized on its working protocol and challenges. A new development such as electronic nose test is also highlighted. Moreover we have also explored the limitations and constraints restraining the wide use of these BT. We conclude that breath testing has an enormous potential to be used as a diagnostic modality. In addition it offers distinct advantages over the traditional invasive methods commonly employed.

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The 13C-Xylose Breath Test for the Diagnosis of Small Bowel Bacterial Overgrowth in Children

Abstract: Our preliminary results suggest that with a dose of 50 mg 13C-xylose, breath test results reliably predict small-bowel bacterial overgrowth in susceptible children.

Cited by 38 publications

References 11 publications

Small bowel bacterial overgrowth: A negative factor in gut adaptation in pediatric SBS

Small bowel bacterial overgrowth: A negative factor in gut adaptation in pediatric SBS

Use of the lactose-[13C]ureide breath test for diagnosis of small bowel bacterial overgrowth: comparison to the glucose hydrogen breath test

Update on diagnostic value of breath test in gastrointestinal and liver diseases

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