The 15 kDa Selenoprotein: Insights into Its Regulation and Function

Carlson, Bradley A.; Hartman, Janelle M.; Tsuji, Petra A.

doi:10.1007/978-3-319-41283-2_19

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…Several studies examined its possible role in cancer [ 103 , 104 ]. Altered expression, both high and low, has been linked to a higher cancer risk in different tissues, including lung, breast, prostate, and liver [ 105 ]. Similarly, common genetic variants in SELENOF have been studied for their relationship with higher cancer risk [ 105 ].…”

Section: Selenoproteinsmentioning

confidence: 99%

“…Altered expression, both high and low, has been linked to a higher cancer risk in different tissues, including lung, breast, prostate, and liver [ 105 ]. Similarly, common genetic variants in SELENOF have been studied for their relationship with higher cancer risk [ 105 ]. SELENOM is expressed in the brain and shows neuroprotective properties.…”

Section: Selenoproteinsmentioning

confidence: 99%

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Historical Roles of Selenium and Selenoproteins in Health and Development: The Good, the Bad and the Ugly

Tsuji

Santesmasses

Lee

et al. 2021

IJMS

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Selenium is a fascinating element that has a long history, most of which documents it as a deleterious element to health. In more recent years, selenium has been found to be an essential element in the diet of humans, all other mammals, and many other life forms. It has many health benefits that include, for example, roles in preventing heart disease and certain forms of cancer, slowing AIDS progression in HIV patients, supporting male reproduction, inhibiting viral expression, and boosting the immune system, and it also plays essential roles in mammalian development. Elucidating the molecular biology of selenium over the past 40 years generated an entirely new field of science which encompassed the many novel features of selenium. These features were (1) how this element makes its way into protein as the 21st amino acid in the genetic code, selenocysteine (Sec); (2) the vast amount of machinery dedicated to synthesizing Sec uniquely on its tRNA; (3) the incorporation of Sec into protein; and (4) the roles of the resulting Sec-containing proteins (selenoproteins) in health and development. One of the research areas receiving the most attention regarding selenium in health has been its role in cancer prevention, but further research has also exposed the role of this element as a facilitator of various maladies, including cancer.

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Section: Selenoproteinsmentioning

confidence: 99%

Section: Selenoproteinsmentioning

confidence: 99%

Historical Roles of Selenium and Selenoproteins in Health and Development: The Good, the Bad and the Ugly

Tsuji

Santesmasses

Lee

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…The 15 kDa selenoprotein, selenoprotein F (SELENOF; SEP15), has been found to be upregulated in a wide variety of cancers and reduced in others (Carlson et al, 2016). Regarding metastasis, SELENOF was shown to promote both anchorage-dependent and anchorage-independent growth and formation of experimental metastases of mouse colon carcinoma CT26 cells (Tsuji, et al, 2015).…”

Section: Other Potential Roles For Selenoproteins In Metastasismentioning

confidence: 99%

Selenoproteins and Metastasis

Marciel

Hoffmann

2017

Advances in Cancer Research

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Cancer survival is largely impacted by the dissemination of cancer cells from the original tumor site to secondary tissues or organs through metastasis. Targets for anti-metastatic therapies have recently become a focus of research, but progress will require a better understanding of the molecular mechanisms driving metastasis. Selenoproteins play important roles in many of the cellular activities underlying metastasis including cell adhesion, matrix degradation and migration, invasion into the blood and extravasation into secondary tissues, and subsequent proliferation into metastatic tumors along with the angiogenesis required for growth. In this review the roles identified for different selenoproteins in these steps and how they may promote or inhibit metastatic cancers is discussed. These roles include selenoenzyme modulation of redox tone and detoxification of reactive oxygen species, calcium homeostasis and unfolded protein responses regulated by endoplasmic reticulum selenoproteins, and the multiple physiological responses influenced by other selenoproteins.

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Chapter 2 Molecular mechanisms of selenium action: selenoproteins

Surai

2018

Selenium in Poultry Nutrition and Health

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The 15 kDa Selenoprotein: Insights into Its Regulation and Function

Cited by 3 publications

References 41 publications

Historical Roles of Selenium and Selenoproteins in Health and Development: The Good, the Bad and the Ugly

Historical Roles of Selenium and Selenoproteins in Health and Development: The Good, the Bad and the Ugly

Selenoproteins and Metastasis

Chapter 2 Molecular mechanisms of selenium action: selenoproteins

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