The 1982 revised criteria for the classification of systemic lupus erythematosus

Tan, Eng M.; Cohen, Alan S.; Fries, James F.; Masi, Alfonse T.; McShane, Dennis J.; Rothfield, Naomi F.; Schaller, Jane G.; Talal, Norman; Winchester, Robert

doi:10.1002/art.1780251101

Cited by 12,657 publications

(7,643 citation statements)

References 6 publications

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“…The inclusion criteria were fulfillment of ≥4 American College of Rheumatology (ACR) criteria for SLE 13, 14, ages ≥16 years, literate ability in the English language, willingness to give written informed consent, and a flare of SLE requiring specific treatment. A flare was defined as a significant increase in disease activity, resulting in a British Isles Lupus Assessment Group 2004 (BILAG‐2004) index A or B score, based on criteria that are new or worse 15, 16, 17.…”

Section: Methodsmentioning

confidence: 99%

Sensitivity to Change and Minimal Important Differences of the LupusQoL in Patients With Systemic Lupus Erythematosus

McElhone

Abbott

Sutton

et al. 2016

Arthritis Care & Research

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ObjectiveAs a health‐related quality of life (HRQOL) measure, the LupusQoL is a reliable and valid measure for adults with systemic lupus erythematosus (SLE). This study evaluates the responsiveness and minimal important differences (MIDs) for the 8 LupusQoL domains.MethodsPatients experiencing a flare were recruited from 9 UK centers. At each of the 10 monthly visits, HRQOL (LupusQoL, Short Form 36 health survey [SF‐36]), global rating of change (GRC), and disease activity using the British Isles Lupus Assessment Group 2004 index were assessed. The responsiveness of the LupusQoL and the SF‐36 was evaluated primarily when patients reported an improvement or deterioration on the GRC scale and additionally with changes in physician‐reported disease activity. MIDs were estimated as mean changes when minimal change was reported on the GRC scale.ResultsA total of 101 patients were recruited. For all LupusQoL domains, mean HRQOL worsened when patients reported deterioration and improved when patients reported an improvement in GRC; SF‐36 domains showed comparable responsiveness. Improvement in some domains of the LupusQoL/SF‐36 was observed with a decrease in disease activity, but when disease activity worsened, there was no significant change. LupusQoL MID estimates for deterioration ranged from −2.4 to −8.7, and for improvement from 3.5 to 7.3; for the SF‐36, the same MID estimates were −2.0 to −11.1 and 2.8 to 10.9, respectively.ConclusionAll LupusQoL domains are sensitive to change with patient‐reported deterioration or improvement in health status. For disease activity, some LupusQoL domains showed responsiveness when there was improvement but none for deterioration. LupusQoL items were derived from SLE patients and provide the advantage of disease‐specific domains, important to the patients, not captured by the SF‐36.

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Section: Methodsmentioning

confidence: 99%

Sensitivity to Change and Minimal Important Differences of the LupusQoL in Patients With Systemic Lupus Erythematosus

McElhone

Abbott

Sutton

et al. 2016

Arthritis Care & Research

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“…Patients and pedigrees were recruited as previously described (23). All affected individuals met at least 4 components of the American College of Rheumatology (ACR) 1982 revised criteria for SLE (24), and the relationship between affected individuals within each pedigree was potentially informative for genetic linkage analysis.…”

Section: Methodsmentioning

confidence: 99%

Increased prevalence of renal disease in systemic lupus erythematosus families with affected male relatives

Stein

Olson

Gray‐McGuire

et al. 2002

Arthritis & Rheumatism

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Objective. To distinguish familial differences from sex-related differences in the clinical manifestations of systemic lupus erythematosus (SLE).Methods. A total of 372 affected individuals from 160 multiplex SLE pedigrees were analyzed. Twenty-five of these pedigrees contained at least 1 affected male relative. Comparisons of the presence of each of the 11 1982 American College of Rheumatology criteria for SLE were made between female family members with affected male relatives and those without affected male relatives, using Fisher's exact tests.Results. The presence of renal disease was significantly increased in female family members with an affected male relative when compared with those with no affected male relative (68% and 43%, respectively; P ‫؍‬ 0.002). This trend remained after stratifying by race and was most pronounced in European Americans. A familial basis for differences in hematologic and immunologic manifestations was also suggested, while arthritis and dermatologic features appeared to be most influenced by sex.Conclusion. Our results demonstrate that the increased prevalence of renal disease previously reported in men with SLE is, in large part, a familial rather than sex-based difference, at least in multiplex SLE families. Distinguishing familial from sex-related differences may facilitate efforts to understand the genetic and hormonal factors that underlie this complex autoimmune disease.

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“…Diagnoses were made according to a review of clinical charts and information from the attending physicians, and were based on American College of Rheumatology criteria (29)(30)(31) and on Sjogren's syndrome classification criteria (32).…”

Section: Methodsmentioning

confidence: 99%

Two major autoantigen—Antibody systems of the mitotic spindle apparatus

Andrade

Chan

Peebles

et al. 1996

Arthritis & Rheumatism

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Objective. To characterize human autoantigenantibody systems related to the mitotic poles and spindles.Methods. Thirty-seven human sera with autoantibodies staining mitotic poles and spindles in indirect immunofluorescence (IIF) studies were further characterized by immunofluorescence on mitotic cells and by immunoblotting and immunoprecipitation. Clinical diagnoses meeting the American College of Rheumatology criteria were based on chart review and interview with the corresponding physicians.ResuUs. Two autoantibody systems reactive with mitotic poles and spindles were defined. Type 1 nuclear mitotic apparatus (NuMA-1) antibodies were identified in the serum of 30 patients. Interphase cells showed a fine, speckled, nuclear staining, while mitotic cells had bright staining of the rim of the centrosomes and light staining of the spindles proximal to the centrosomes. In telophase, the staining shifted from the centrosomes to the reforming nuclei. On immunoblotting, antiNuMA-1 sera reacted with a 210-kd protein. The reactivity of these sera was identified (with the aid of reference antibodies) as the previously described NuMA antigen-antibody system. Clinical information was available for only 17 of the 30 patients with antiNuMA-1; of these, 17 (53%) had clinical and lip biopsy findings that met the criteria for Sjiigren's syndrome.Publication 7668-MEM from The Scripps Research Institute.

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The 1982 revised criteria for the classification of systemic lupus erythematosus

Cited by 12,657 publications

References 6 publications

Sensitivity to Change and Minimal Important Differences of the LupusQoL in Patients With Systemic Lupus Erythematosus

Sensitivity to Change and Minimal Important Differences of the LupusQoL in Patients With Systemic Lupus Erythematosus

Increased prevalence of renal disease in systemic lupus erythematosus families with affected male relatives

Two major autoantigen—Antibody systems of the mitotic spindle apparatus

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