The 2004 Fitts Lecture: Current Perspective on Combat Casualty Care

Holcomb, John B.

doi:10.1097/01.ta.0000188010.65920.26

Cited by 50 publications

(27 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A 48-h postexposure time period was chosen for this study because of both practical and medical reasons as outlined previously for both thermal and sulfur mustard cutaneous injuries on the battlefield [18]. Following injury, wounded military personnel can typically reach an intensive care unit in the United States and receive treatment within 2-4 days [27,28]. Moreover, cutaneous bromine exposure often leads to delayed signs of injury, and Sagi et al [5] observed that 40% of 59 patients did not seek medical aid until at least 1 day after injury.…”

Section: Discussionmentioning

confidence: 99%

An assessment of transcriptional changes in porcine skin exposed to bromine vapor

Rogers

Price

Wendling

et al. 2011

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Bromine is an industrial chemical that can cause severe cutaneous burns. This study was a preliminary investigation into the effect of cutaneous exposure to bromine vapor using a weanling swine burn model and microarray analysis. Ventral abdominal sites were exposed to a mean calculated bromine vapor concentration of 0.69 g L(-1) for 10 or 20 min. At 48 h postexposure, total RNA from skin samples was isolated, processed, and hybridized to Affymetrix GeneChip Porcine Genome Arrays. Expression analysis revealed that bromine vapor exposure for 10 or 20 min promoted similar transcriptional changes in the number of significantly modulated probe sets. A minimum of 83% of the probe sets was similar for both exposure times. Ingenuity pathways analysis revealed eight common biological functions among the top 10 functions of each experimental group, in which 30 genes were commonly shared among 19 significantly altered signaling pathways. Transcripts encoding heme oxygenase 1, interleukin-1β, interleukin 2 receptor gamma chain, and plasminogen activator inhibitor-1 were identified as common potential therapeutic targets for Phase II/III clinical trial or FDA-approved drugs. The present study is an initial assessment of the transcriptional responses to cutaneous bromine vapor exposure identifying molecular networks and genes that could serve as targets for developing therapeutics for bromine-induced skin injury.

show abstract

Section: Discussionmentioning

confidence: 99%

An assessment of transcriptional changes in porcine skin exposed to bromine vapor

Rogers

Price

Wendling

et al. 2011

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

“…It should be emphasized, however, that it is important to correctly and descriptively categorize combat casualties, as well as wounding patterns, to maintain consistency when comparing combat casualty statistics within and between wars. 22,27,28 Combat casualty care epidemiology reporting is valid only when a clearly defined population is studied and combat casualty classification is reliably performed. Calculating combat casualty care statistics using the Directorate for Information Operations and Reports is limited by the classification of service members and a priori categorization of individuals KIA/DOW in a single status.…”

Section: Discussionmentioning

confidence: 99%

Combat wounds in Iraq and Afghanistan from 2005 to 2009

Belmont

McCriskin

Sieg

et al. 2012

Journal of Trauma and Acute Care Surgery

195

110

View full text Add to dashboard Cite

“…18,31,34,37 Defining the population studied is necessary to perform valid comparisons and meaningful conclusions between wars. The inclusion of soldiers killed in action, RTD, and nonbattle injuries in any cohort analyzed will affect the distribution of musculoskeletal wounds and mechanism of injury.…”

Section: Discussionmentioning

confidence: 99%