The 2007 WHO Classification of Tumours of the Central Nervous System

Abstract

The fourth edition of the World Health Organization (WHO) classiWcation of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneuronal tumour of the fourth ventricle, papillary tumour of the pineal region, pituicytoma and spindle cell oncocytoma of the adenohypophysis. Histological variants were added if there was evidence of a diVerent age distribution, location, genetic proWle or clinical behaviour; these included pilomyxoid astrocytoma, anaplastic medulloblastoma and medulloblastoma with extensive nodularity. The WHO grading scheme and the sections on genetic proWles were updated and the rhabdoid tumour predisposition syndrome was added to the list of familial tumour syndromes typically involving the nervous system. As in the previous, 2000 edition of the WHO 'Blue Book', the classiWcation is accompanied by a concise commentary on clinico-pathological characteristics of each tumour type. The 2007 WHO classiWcation is based on the consensus of an international Working Group of 25 pathologists and geneticists, as well as contributions from more than 70 international experts overall, and is presented as the standard for the deWnition of brain tumours to the clinical oncology and cancer research communities world-wide. Introduction and historical annotation

BRAF‐V600E immunohistochemistry in a large series of glial and glial–neuronal tumors

“…However, this finding leads to discuss the detection threshold of MB techniques. GG harbor a variable proportion of ganglion cells, from a few scattered cells to an authentic gangliocytoma (tumor composed entirely of ganglion cells with no glial tumor component) (Louis et al., 2007). The glial component is most often predominant in GG.…”

“…Tumors with the following histopathological diagnoses were selected: PA, pilomyxoid astrocytoma (PMA), ganglioglioma/gangliocytoma (GG/GC), anaplastic ganglioglioma (AGG), pleomorphic xanthoastrocytoma (PXA), anaplastic pleomorphic xanthoastrocytoma (APXA), dysembryoplastic neuroepithelial tumor (DNT), desmoplastic infantile ganglioglioma (DIG), astroblastoma (AB), and papillary glioneuronal tumor (PGNT). All cases were reviewed by two pathologists (one junior [QB] and one expert neuropathologist [AR]) and classified according to the 2016 WHO classification of tumors of the CNS (Louis et al., 2007). The entire cohort is described in Table 1.…”

“…Circumscribed glial and mixed glial–neuronal tumors (GNT) most often develop in children and young adults and are usually low‐grade (grade I or II) according to the 2016 World Health Organization (WHO) classification (Louis et al., 2007). …”

Prognostic value of preoperative von Willebrand factor plasma levels in patients with Glioblastoma

“…Gliomas are the most common type of primary tumors of the central nervous system and among them, GBM is the most common primary malignant brain tumor in adults and with the worst prognosis 21. Several clinical predictors of survival have been identified, such as age, preoperative functional status, and tumor extent 22.…”

Rapid diffuse pleural thickening due to metastatic meningioma

“…The exact frequency of meningioma metastasizing to the pleura is unknown, but previous studies have reported the range to be from 5.5% 2 to 9.0% 4, suggesting that it is an extremely rare event. However, for WHO grade 3 meningioma 3, the rate of metastasis to other organs was as high as 42.8% 1, and only 4.3% to the pleura 2.…”