The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: Phase 2 methodological report

Neogi, Tuhina; Aletaha, Daniel; Silman, Alan J.; Naden, Raymond L.; Felson, David T.; Aggarwal, Rohit; Bingham, Clifton O.; Birnbaum, Neal S.; Burmester, Gerd R; Bykerk, Vivian P.; Cohen, Marc D.; Combe, Bernard; Costenbader, Karen H.; Dougados, Maxime; Emery, Paul; Ferraccioli, Gianfranco; Hazes, Johanna M. W.; Hobbs, Kathryn; Huizinga, Tom W J; Kavanaugh, Arthur; Kay, Jonathan; Khanna, Dinesh; Kvien, Tore K; Laing, Timothy; Liao, Katherine P.; Mease, Philip J.; Ménard, Henri A.; Moreland, Larry W.; Nair, Raj; Pincus, Theodore; Ringold, Sarah; Smolen, Josef S.; Stanisławska-Biernat, Ewa; Symmons, Deborah; Tak, Paul P.; Upchurch, Katherine S.; Vencovský, Jiří; Wolfe, Frederick; Hawker, Gillian

doi:10.1002/art.27580

Cited by 264 publications

(171 citation statements)

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“…Phase 3, which is the focus of this report, describes the derivation, from the previous 2 phases, of the final classification criteria set. The details of the methods and results from Phases 1 and 2 are provided elsewhere (25,26), and are briefly summarized below.…”

Section: Overview On Hypothesis and Methods Of Phases 1 Andmentioning

confidence: 99%

“…When appropriate, these judgments were informed by the results of Phase 1 and other available literature. The relative importance or weights of these domains and their categories were determined by means of decision science theory and conjoint adaptive technology, using the computerized 1000Minds program (www.1000minds.com) in an interactive and iterative process (26). This analysis permitted the calculation of an individual's score of the likelihood of developing RA from 0 to 100, where a higher score indicated greater likelihood of RA development.…”

Section: Overview On Hypothesis and Methods Of Phases 1 Andmentioning

confidence: 99%

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2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

Aletaha

Neogi

Silman³

et al. 2010

Arthritis & Rheumatism

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This criteria set has been approved by the American College of Rheumatology (ACR) Board of Directors and the European League Against Rheumatism (EULAR) ExecutiveCommittee. This signifies that the criteria set has been quantitatively validated using patient data, and it has undergone validation based on an external data set. All presenting with undifferentiated inflammatory synovitis, factors that best discriminated between those who were and those who were not at high risk for persistent and/or erosive disease-this being the appropriate current paradigm underlying the disease construct "rheumatoid arthritis." Results. In the new criteria set, classification as "definite RA" is based on the confirmed presence of synovitis in at least 1 joint, absence of an alternative diagnosis that better explains the synovitis, and achievement of a total score of 6 or greater (of a possible 10) from the individual scores in 4 domains: number and site of involved joints (score range 0-5), serologic abnormality (score range 0-3), elevated acute-phase response (score range 0-1), and symptom duration (2 levels; range 0-1).Conclusion. This new classification system redefines the current paradigm of RA by focusing on features at earlier stages of disease that are associated with persistent and/or erosive disease, rather than defining the disease by its late-stage features. This will refocus attention on the important need for earlier diagnosis and institution of effective disease-suppressing therapy to prevent or minimize the occurrence of the undesirable sequelae that currently comprise the paradigm underlying the disease construct "rheumatoid arthritis."

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Section: Overview On Hypothesis and Methods Of Phases 1 Andmentioning

confidence: 99%

Section: Overview On Hypothesis and Methods Of Phases 1 Andmentioning

confidence: 99%

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

Aletaha

Neogi

Silman³

et al. 2010

Arthritis & Rheumatism

Self Cite

8,092

5,050

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“…In addition, although low serum Fe and transferrin, anemia, high ESR, and even higher CRP can be observed in patients with inflammatory arthritis like RA, no clinical evidence of synovitis involving peripheral joints of hands and feet that is typical of RA was observed. Finally, and according both to the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism and to the 1987 ACR classification criteria [9][10][11] , our patient did not meet the criteria for RA diagnosis. Table 2.…”

Section: Discussionmentioning

confidence: 83%

Idiopathic chronic polyserositis with massive ascites responding to colchicine in an adult: A case report

Fernández-Ayala

Carrascosa

Salcines-Caviedes

2014

CRIM

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Objective: While there are many different causes of ascites, most cases are due to cirrhosis. However, a serum/ascites albumin gradient <1.1 indicates that the ascites is not induced by portal hypertension and mandates a search for other etiologies, including causes of serositis. We describe a 70-year-old patient with persistent ascites and pleuropericarditis who underwent a successful outcome while on colchicine treatment. Methods:This study was delineated on a case-report basis. Besides supportive care measures, we performed a comprehensive clinical and complementary assessment of the patient, which included laboratory tests, imaging techniques, endoscopic evaluation, full microbiological and pathological studies, diagnostic laparoscopy and thoracoscopy, and genetic testing for autoinflammatory diseases. Results:Diagnostic workup failed to demonstrate the presence of an underlying etiologic disorder. Large-volume paracentesis was performed once monthly during 13 consecutive months due to painless, massive accumulation of peritoneal fluid. Eventually, colchicine therapy induced a dramatic response with clinical and radiological disappearance of polyserositis within three months of starting on the drug. While on colchicine, the disease has not recurred throughout a thirty two months period of follow-up so far. To our knowledge, the occurrence of idiopathic, chronic refractory ascites and pleuropericarditis resolved under colchicine treatment in an adult not diagnosed with Familial Mediterranean Fever is an exceptional event.Conclusion: We suggest that in adult patients suffering from idiopathic chronic polyserositis including massive ascites the possible existence of an underlying autoinflammatory condition should be sought. In such a case, a colchicine trial might be regarded as an early suitable therapeutic option.

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“…The final effect is usually the destruction of articular cartilage and ankylosis of the joints, with a prevalence of the wrist and small joints of the hand. Diagnostic criteria have recently been revised (Aletaha et al, 2010;Neogi et al, 2010). The prevalence of RA is about 1% in the total population, being women more affected than men in a ratio of approximately 2-3:1 (Alamanos & Drosos, 2005).…”

Section: Introductionmentioning

confidence: 99%

HLA and Citrullinated Peptides in Rheumatoid Arthritis

Álvarez¹

2011

Autoimmune Disorders - Pathogenetic Aspects

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The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: Phase 2 methodological report

Cited by 264 publications

References 6 publications

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

Idiopathic chronic polyserositis with massive ascites responding to colchicine in an adult: A case report

HLA and Citrullinated Peptides in Rheumatoid Arthritis

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