The 2011–2014 prevalence of eosinophilic oesophagitis in the elderly amongst 10 million patients in the United States

Maradey–Romero, Carla; Prakash, Ravi; Lewis, Steven; Perzynski, Adam T.; Fass, Ronnie

doi:10.1111/apt.13171

Cited by 53 publications

(52 citation statements)

References 29 publications

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“…It currently encompasses 23 integrated health systems consisting of 360 hospitals, 315,000 providers, and over 50 million unique patients. It collects data through a healthcare gateway server behind the firewall of participating institutions[5]. The data are collected from billing inquiries, electronic health records, and laboratory systems.…”

Section: Methodsmentioning

confidence: 99%

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Heart failure in patients with human immunodeficiency virus infection: Epidemiology and management disparities

Al‐Kindi

ElAmm

Ginwalla

et al. 2016

International Journal of Cardiology

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Background Persons living with HIV are at a higher risk of cardiovascular disease despite effective antiretroviral therapy and dramatic reductions in AIDS-related conditions. We sought to identify the epidemiology of heart failure (HF) among persons living with HIV in the United States in an era of contemporary antiretroviral therapy. Methods Explorys is an electronic healthcare database that aggregates medical records from 23 healthcare systems nationwide. Using systemized nomenclature of medicine - clinical terms (SNOMED-CT), we identified adult patients (age > 18), who had active records over the past year (September 2014–September 2015). We described the prevalence of HF in HIV patients by demographics and treatment and compared them to HIV-uninfected controls. Results Overall, there were 36,400 patients with HIV and 12,208,430 controls. The overall prevalence of HF was 7.2% in HIV and 4.4% in controls (RR 1.66 [1.60–1.72], p<0.0001). The relative risk of HF associated with HIV infection was higher among women and younger age groups. Patients receiving antiretroviral therapy had only marginally lower risk (6.4% vs 7.7%, p<0.0001) of HF compared to those who were untreated. Compared to uninfected patients with HF, HIV patients with HF were less likely to receive antiplatelet drugs, statins, diuretics, and ACE/ARBs (p<0.0001 for all comparisons). For patients with HIV and HF, receiving care from a cardiologist was associated with higher use of antiplatelets, statins, betablockers, ACE/ARBs, and diuretics. Conclusions Persons with HIV are at higher risk for HF in this large contemporary sample that includes both men and women. Although the prevalence of heart failure is higher in older HIV patients, the relative risk associated with HIV is highest in young people and in women. HIV patients are less likely to have HF optimally treated, but cardiology referral was associated with higher treatment rates.

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Section: Methodsmentioning

confidence: 99%

“…The database rounds number of patients to the nearest 10 for an added data protection. This platform has been used for research purposes and has been validated in fields of orthopedics[6], hematology[7], surgery[8], gastroenterology[5], gynecology[9] among others.…”

Section: Methodsmentioning

confidence: 99%

Heart failure in patients with human immunodeficiency virus infection: Epidemiology and management disparities

Al‐Kindi

ElAmm

Ginwalla

et al. 2016

International Journal of Cardiology

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“…First described in 1978 [2], EoE has become increasingly common in both adults and children with recent studies showing increasing incidence and prevalence [3–6]. Numerous studies in the United States and other industrial countries have reported prevalence rates of EoE in the adult and pediatric population, which have ranged from 2.3 to 400 cases per 100,000 in various time frames between 1976 to 2014 [4–17]. However, most of these studies were niche studies, specific to some locations, and have many limitations, including small sample sizes and referral bias.…”

Section: Background and Aimsmentioning

confidence: 99%

The 2010–2015 Prevalence of Eosinophilic Esophagitis in the USA: A Population-Based Study

Mansoor

Cooper

2016

Dig Dis Sci

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Background & Aims Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder with increasing prevalence. However, epidemiologic data has mostly been acquired from small studies. We sought to describe the epidemiology of EoE in the United States, utilizing a large database. Methods We queried a commercial database (Explorys Inc, Cleveland, OH), an aggregate of electronic health record data from 26 major integrated US healthcare systems from 1999 to July 2015. We identified an aggregated patient cohort of eligible patients with EoE and a history of proton pump inhibitor use between July 2010 to July 2015, based on Systematized Nomenclature Of Medicine – Clinical Terms (SNOMED-CT). We calculated the prevalence of EoE among different patient groups. Results Of the 30,301,440 individuals in the database, we identified 7,840 patients with EoE with an overall prevalence of 25.9/100,000 persons. Prevalence was higher in males than females (Odds Ratio [OR] 2.00; 95% CI=1.92–2.10, p<0.0001), Caucasians vs. African-Americans and Asians (OR 2.00; 95% CI: 1.86–2.14, p<0.0001) and adults (18–65yrs) vs. elderly (>65yrs) and children (<18yrs) (OR 1.63; 95% CI: 1.54–1.71, p<0.0001). Compared with controls (individuals in database without EoE), individuals with EoE were more likely to have other gastrointestinal diagnoses such as dysphagia and at least one allergic condition. Conclusions In this large study, we found that the estimated prevalence of EoE in the US is 25.9/100,000, which is at the lower end of prevalence rates reported in US and other industrial countries. We confirmed that EoE has a strong association with allergic and gastrointestinal diagnoses.

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“…Finally, the percentage of asthma patients was significantly higher among the paediatric age group than the elderly in this study. 1 It is known that there is an association between GERD and bronchial asthma, and the severity of asthma improves significantly after PPI therapy. 3 Thus, it would have been better to report the percentage of PPI use in this subgroup to determine the exact correlation between EoE and asthma.…”

mentioning

confidence: 99%

Letter: oesophageal eosinophilia must be excluded before determining prevalence of eosinophilic oesophagitis

Sakin¹,

Kekilli

Uygun³

et al. 2015

Aliment Pharmacol Ther

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The 2011–2014 prevalence of eosinophilic oesophagitis in the elderly amongst 10 million patients in the United States

Abstract: SUMMARY BackgroundEosinophilic oesophagitis (EoE) is primarily diagnosed by clinicians. There are less than a handful of epidemiological studies in EoE that have included elderly patients (>65 years).

Cited by 53 publications

References 29 publications

Heart failure in patients with human immunodeficiency virus infection: Epidemiology and management disparities

Heart failure in patients with human immunodeficiency virus infection: Epidemiology and management disparities

The 2010–2015 Prevalence of Eosinophilic Esophagitis in the USA: A Population-Based Study

Letter: oesophageal eosinophilia must be excluded before determining prevalence of eosinophilic oesophagitis

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