The 2014 ACR annual meeting: a bird’s eye view of autoimmunity in 2015

Selmi, Carlo; Cantarini, Luca; Kivity, Shaye; Dagaan, Amir; Shovman, Ora; Zandman‐Goddard, Gisele; Perricone, Carlo; Amital, Howard; Toubi, Elias; Shoenfeld, Yehuda

doi:10.1016/j.autrev.2015.03.003

Cited by 10 publications

(6 citation statements)

References 137 publications

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“…We can reasonably infer that, on one hand, the autoimmune disease can attack the lacrimal gland tissue via immune reaction to achieve the reduction of the tear secretion; on the other hand, the autoimmune disease can attack the ocular surface epithelial cells and promote the ocular surface inflammatory reaction to cause the damage of accessory lacrimal glands and goblet cells and promote the occurrence and growth of ocular surface inflammatory reactions and result in the damage of ocular surface epithelial cells and the reduction of mucin secretion. The integrated action of multiple factors and pathways enables the immune-related dry eye to become a serious mixed type of dry eye [24–29]. …”

Section: Discussionmentioning

confidence: 99%

Analysis of Clinical Characteristics of Immune-Related Dry Eye

Wang

Chen

et al. 2017

Journal of Ophthalmology

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Aim To discuss the clinical characteristics of immune-related dry eye. Methods Simple dry eye (SDE) group: we selected 224 patients of simple dry eye with no systemic lesions. Immune-related dry eye (IRDE) group: we selected 207 patients of dry eye complicated with immune system diseases, including 70 cases of Sjögren's syndrome (SS), 72 cases of systemic lupus erythematosus (SLE), and 65 cases of rheumatoid arthritis (RA). The classification of all patients was performed. The difference between the two groups was compared, including age, gender, ocular surface fluorescein staining and inflammatory reaction, tear breakup time (TBUT), Shirmer I test, confocal microscopy scan, and dry eye grading. Results Compared with the SDE group, the patients of IRDE group were younger (P < 0.05). The female patients were significantly more than the male ones (P < 0.05). Corneal staining counts and ocular surface inflammation were significantly increased (P < 0.05). TBUT and Shirmer I test shortened significantly (P < 0.05). Corneal nerve fibers were less, and the number of local lymphocyte was significant increased. The number of dry eye patients in the moderate or above IRDE group was significantly increased (P < 0.05). Conclusions The dry eye symptom and sign and ocular surface inflammation of IRDE were significantly more severe than those of the SDE.

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Section: Discussionmentioning

confidence: 99%

Analysis of Clinical Characteristics of Immune-Related Dry Eye

Wang

Chen

et al. 2017

Journal of Ophthalmology

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“…The risk of NEC among preterm infants peaks between 13 and 21 days, 46,47 and our findings suggest that this risk window is reflected in calprotectin levels. Calprotectin is derived mostly from neutrophils and monocytes, 48 when white blood cell migration to the intestines activates neutrophils to release this protein. 49 Fecal calprotectin has been directly associated with inflammation severity in the small intestine, including NEC.…”

Section: Discussionmentioning

confidence: 99%

Effect of Promoter Polymorphisms on Cytokine Concentration in Preterm Breast Milk and Subsequent Infant Outcomes

et al. 2016

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Background Breast milk concentrations of immune components are variable between women and interleukin (IL) differences may be associated with infant outcomes. Molecular mechanisms for milk variability remain unknown. Objective The aims were to (1) examine the relationship between maternal IL genotypes and milk concentrations of IL4, IL6, and IL10, (2) describe the trajectories of milk IL change, (3) examine whether maternal IL genotypes predict IL trajectories and/or average weekly IL concentration, and (4) examine if weekly IL levels and/or IL trajectories are associated with infant outcomes. Methods Milk aliquots were collected from each feeding of mother's own milk and pooled weekly. DNA was extracted from 1 sample of each mother's breast milk whey (n = 64), and single nucleotide polymorphisms (SNPs) of IL genes were genotyped. Milk IL concentrations were measured and trajectory analysis examined IL milk change over time. Multivariate breast milk IL concentration analyses controlled for gestational age and prepregnancy body mass index. Multivariate infant outcome (n = 73) analyses controlled for gestational age and the ratio of human milk to total milk. Results Trajectory analysis resulted in linear group shapes, with 2 distinct subgroups in IL6 and 3 subgroups in IL4 and IL10. Trajectory groups trended toward significance with calprotectin, intraventricular hemorrhage, and blood transfusions. Multivariate analyses resulted in trending associations between maternal SNPs and subsequent IL6 and IL10 milk levels. There was a trending relationship between IL milk levels and both fecal calprotectin and intraventricular hemorrhage. Conclusion Maternal IL SNPs may affect IL breast milk levels and IL milk levels may be associated with infant outcomes.

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“…Furthermore, PR3 and MPO-ANCAs were detected by commercially available enzyme-linked immunosorbent assay (ELISA) (“anti-PR3-hn-hr IgG” and “anti-MPO-hn-hr IgG” Euroimmun, Lubeck, Germany). 17–20 Values above 20 IU/mL were considered positive.…”

Section: Methodsmentioning

confidence: 99%

Antineutrophil Cytoplasmic Antibodies Associated With Infective Endocarditis

et al. 2016

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To determine the prevalence of antineutrophil cytoplasmic antibodies (ANCA) in patients with infective endocarditis (IE) in internal medicine; and to compare clinical and biochemical features and outcome between patients exhibiting IE with and without ANCA.Fifty consecutive patients with IE underwent ANCA testing. The medical records of these patients were reviewed.Of the 50 patients with IE, 12 exhibited ANCA (24%). ANCA-positive patients with IE exhibited: longer duration between the onset of first symptoms and IE diagnosis (P = 0.02); and more frequently: weight loss (P = 0.017) and renal impairment (P = 0.08), lower levels of C-reactive protein (P = 0.0009) and serum albumin (P = 0.0032), involvement of both aortic and mitral valves (P = 0.009), and longer hospital stay (P = 0.016). Under multivariate analysis, significant factors for ANCA-associated IE were: longer hospital stay (P = 0.004), lower level of serum albumin (P = 0.02), and multiple valve involvement (P = 0.04). Mortality rate was 25% in ANCA patients; death was because of IE complications in all these patients.Our study identifies a high prevalence of ANCA in unselected patients with IE in internal medicine (24%). Our findings further underscore that ANCA may be associated with a subacute form of IE leading to multiple valve involvement and more frequent renal impairment. Because death was due to IE complications in all patients, our data suggest that aggressive therapy may be required to improve such patients’ outcome.

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The 2014 ACR annual meeting: a bird’s eye view of autoimmunity in 2015

Cited by 10 publications

References 137 publications

Analysis of Clinical Characteristics of Immune-Related Dry Eye

Analysis of Clinical Characteristics of Immune-Related Dry Eye

Effect of Promoter Polymorphisms on Cytokine Concentration in Preterm Breast Milk and Subsequent Infant Outcomes

Antineutrophil Cytoplasmic Antibodies Associated With Infective Endocarditis

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