The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part A: Renal, Penile, and Testicular Tumours

Moch, Holger; Cubilla, Antonio L.; Humphrey, Peter A.; Reuter, Victor E.; Ulbright, Thomas M.

doi:10.1016/j.eururo.2016.02.029

Cited by 2,769 publications

(2,768 citation statements)

References 99 publications

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“…These changes are seen if you compare the WHO classification of renal neoplasms in 2004 5 to the WHO classification of renal neoplasms in 2016. 8 These major classification changes occur after enough new information emerges from a variety of studies to warrant a consensus conference to review the classification system used. 9 If PTCRs are not aware of the changes in the RCC classification system or if there is a lag time between updates, these neoplasms will continue to be recorded inaccurately.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of kidney cancer diagnosis and histological subtype within Canadian cancer registry data

Himmelman

Merrimen

Matheson

et al. 2017

CUAJ

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Introduction: Provincial/territorial cancer registries (PTCRs) are the mainstay for Canadian population-based cancer statistics. Each jurisdiction captures this data in a population-based registry, including the Nova Scotia Cancer Registry (NSCR). The goal of this study was to describe data from the NSCR regarding renal cell carcinoma (RCC) pathology subtype and method of diagnosis and compare it to the actual pathology reports to determine the accuracy of diagnosis and histological subtype assignment. Methods: This retrospective analysis included patients diagnosed with RCC in the NSCR from 2006-2010 with an ICD-O-3 code C64.9 seen or treated in the largest NS health district. From the NSCR, method of diagnosis and pathological diagnosis was recorded. All diagnoses of non-clear-cell RCC (nonccRCC) from NSCR were compared to the actual pathology report for descriptive comparison and reasons for discordance. Results: 723 patients make up the study cohort. 81.3% of patients were diagnosed by nephrectomy, 11.1% radiography, 6.9 % biopsy, and 0.7% autopsy. By NSCR data, 52.8% had clear-cell (ccRCC), 20.5% RCC not otherwise specified (NOS), 12.7% papillary, 4% chromophobe, and the rest had other nonccRCC subtypes. By pathology reports, 69.5% had clear-cell, 15% papillary, 5% chromophobe, only 2.7% RCC NOS. There was a discordance rate of 15.4% between NSCR data and diagnosis from pathology report. Reasons for discordance were not enough information by the pathologist in 45.5%, misinterpretation of report by data coder in 22.2%, and true coding error in 32.3%. Conclusions: When using PTCR for RCC incidence data, it is important to understand how the diagnosis is made, as not all are based on pathological confirmation; in this cohort 11% were based on radiology. One must also be aware that clear-cell and non-clearcell subtypes may differ between the PTCR data and pathology reports. In this study, ccRCC made up 52.8% of the registry diagnoses, but increased to 69.6% on pathology report review. Use of synoptic reporting and ongoing education may improve accuracy of registry data.

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Section: Discussionmentioning

confidence: 99%

Accuracy of kidney cancer diagnosis and histological subtype within Canadian cancer registry data

Himmelman

Merrimen

Matheson

et al. 2017

CUAJ

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“…Where the both combined together showed slightly higher incidence around 90%. 8 Corpora cavernosa invasion is seen in 19% of the patients and urethral invasion alone is seen in 7% of the patients. In 2008 Beijing and colleague showed that urethral involvement alone is associated with better prognosis and better 5-year survival rate than corpora cavernosa invasion alone.…”

Section: Discussionmentioning

confidence: 99%

Clinical study of nodal involvement in carcinoma penis: role of perineural and perivascular invasion in lymph node metastasis

Kumar¹,

Venkateswaran²

2018

Int Surg J

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Background: Penile malignancies constitute a major health problem in the developing countries especially the Afro Asian countries. It constitutes about 10% of all malignancy. The incidence of the penile malignancy is in decreasing trend in many parts of the world due to improved awareness about the personal hygiene. In this study special effort was made to analyze the histopathological correlation in predicting the lymph node involvement particularly the perivascular and perineural invasion of a tumor on his to pathology and its influence on the lymph node metastasis.Methods: After getting prior ethical committee clearance 42 cases of histopathologically proven cases are included in the study. Those patients included are explained about the nature of the study, investigations that are done. They have also discussed the various treatment options available in Thanjavur medical college. Proper consent in patients own language is obtained before including in the study.Results: The most common histological type found in present study was squalors type. More than 90% (93%) shows squamous variety. Verrucous carcinoma was found in two patients. One patient present with the mixed presentation.Conclusions: Tumour with high grade, high stage, and perineural and per vascular invasion is associated with more nodal metastasis. It is highly recommended to carry out nodal dissection in such types of a tumor. Screening for the early stage of the disease and addressing for the inguinal nodes for the high-risk group will significantly reduce the morbidity and mortality of carcinoma penis.

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“…The recent WHO classification of GCNIS replaces other long-held descriptions including Carcinoma in situ (CIS) and intratubular germ cell neoplasia unclassified (ITGNU), as well as less common designations including testicular intraepithelial neoplasia (TIN) and gonocytoma in situ (Moch et al, 2016).…”

Section: Nomenclaturementioning

confidence: 99%

“…It is postulated that these maturation-blocked XY germ cells remain dormant throughout childhood, but following puberty re-initiate proliferation and possess the capacity to transform into invasive seminoma and non-seminoma germ cell tumors (GCT) of the testis, known collectively as Type II testicular GCT. The defective germ cells are called germ cell neoplasia in situ (GCNIS) (Moch et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Germ cell neoplasia in situ: The precursor cell for invasive germ cell tumors of the testis

Spiller

Bowles

2017

The International Journal of Biochemistry & Cell Biology

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractGerm cell neoplasia in situ is the non-invasive precursor cell of origin for type II testicular germ cell tumors. It has long been postulated that germ cell neoplasia in situ is derived from defective germ cell development during embryonic life, and although it is impossible to trace in vivo the progression from fetal germ cell to germ cell neoplasia in situ to tumor, there is a large volume of evidence supporting this theory. Current studies focus on understanding how germ cell neoplasia in situ forms, how these cells are activated at puberty and how they transform to invasive tumors of various subtypes. Such information is informing novel diagnostic and therapeutic options.

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The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part A: Renal, Penile, and Testicular Tumours

Cited by 2,769 publications

References 99 publications

Accuracy of kidney cancer diagnosis and histological subtype within Canadian cancer registry data

Accuracy of kidney cancer diagnosis and histological subtype within Canadian cancer registry data

Clinical study of nodal involvement in carcinoma penis: role of perineural and perivascular invasion in lymph node metastasis

Germ cell neoplasia in situ: The precursor cell for invasive germ cell tumors of the testis

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