The 21-day cumulative irritation assay in man: a half-century summary and re-evaluation

Do, Le Hanh Dung; Maibach, Howard I.

doi:10.1080/15569527.2021.1887885

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…The 21-day cumulative irritation assay was developed as a solution for detecting subtle reactions that may become apparent only after cumulative exposure. 78 The problem with the 21-day test is that like the Draize test it is not designed for multiple formulations. As such, the tandem repeated irritation test (TRIT) was developed to explore the effect of tandem applications which has been reviewed previously.…”

Section: Animal and Human Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Multiple topical product dermatitis: Paradigms in understanding and future perspectives

Mangion,

Mikkonen,

Mackenzie

et al. 2023

JEADV Clinical Practice

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It is common for people to be exposed to multiple topical products daily, either through cosmetics, personal care or drug formulations. This increases the possibility of contact dermatitis and poses a major challenge for treatment as well as the design and regulation of safe and effective topical products. Here, we define the scope of the problem of multiple topical product dermatitis and highlight a strategy for differential diagnosis. The tools currently available for prediction of skin reactions are also discussed along with further work required to improve our ability to (1) identify irritant or sensitising agents and (2) prevent dermatitis occurrence.

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Section: Animal and Human Studiesmentioning

confidence: 99%

“…The 21‐day cumulative irritation assay was developed as a solution for detecting subtle reactions that may become apparent only after cumulative exposure 78 . The problem with the 21‐day test is that like the Draize test it is not designed for multiple formulations.…”

Section: Predictive Studies For Skin Dermatitismentioning

confidence: 99%