The 24-hour pulse wave velocity, aortic augmentation index, and central blood pressure in normotensive volunteers

Abstract

The purpose of this study was to examine the pulse wave velocity, aortic augmentation index corrected for heart rate 75 (AIx@75), and central systolic and diastolic blood pressure during 24-hour monitoring in normotensive volunteers. Overall, 467 subjects (206 men and 261 women) were recruited in this study. Participants were excluded from the study if they were less than 19 years of age, had blood test abnormalities, had a body mass index greater than 2 7.5 kg/m2, had impaired glucose tolerance, or had hypotension or hypertension. Ambulatory blood pressure monitoring (ABPM) with the BPLab® device was performed in each subject. ABPM waveforms were analyzed using the special automatic Vasotens® algorithm, which allows the calculation of pulse wave velocity, AIx@75, central systolic and diastolic blood pressure for “24-hour”, “awake”, and “asleep” periods. Circadian rhythms and sex differences in these indexes were identified. Pending further validation in prospective outcome-based studies, our data may be used as preliminary diagnostic values for the BPLab ABPM additional index in adult subjects.

Evaluation of 24-Hour Arterial Stiffness Indices and Central Hemodynamics in Healthy Normotensive Subjects versus Treated or Untreated Hypertensive Patients: A Feasibility Study

“…All these findings are in line with and confirm those obtained in healthy volunteers or hypertensive patients with other oscillometric devices; although such studies were based on a different technology, they were carried out in smaller groups of subjects and the majority of them evaluated central BP only [ 11 , 24 – 26 ]. Our study also adds data to existing evidence collected in normotensive volunteers with the same technology [ 27 ]. Interestingly, regardless of the awake or asleep period and of the presence or absence of a circadian rhythm and with the only exception of nighttime PWV, average transit time was lower and PWV, AI, and central BP were higher in hypertensive than normotensive individuals.…”

Comparison of the BPLab® sphygmomanometer for ambulatory blood pressure monitoring with mercury sphygmomanometry in pregnant women: validation study according to the British Hypertension Society protocol

“… 12 – 14 It provides normative data for arterial stiffness and central BP indices and allows studying the feasibility of BPLab indices in daily life dynamic conditions. 15 , 16 We believe that this is an additional advantage of BPLab use for ABPM in the antenatal clinic, in the pregnancy day assessment unit, or when admitted to the antenatal ward for hypertension management.…”

Validation of the BPLab® 24-hour blood pressure monitoring system in a pediatric population according to the 1993 British Hypertension Society protocol

“… 8 Moreover, the device was clinically validated for measuring central aortic pressure and parameters of arterial stiffness, 9 – 11 which provides normative data for arterial stiffness and central BP indices. 12 However, validation of the accuracy of the device in the pediatric population has not been performed as yet. Thus, the aim of this study was to validate the accuracy of the device for measuring peripheral arterial BP in “older” children (aged 5–15 years).…”