The 262T&gt;C promoter polymorphism of the catalase gene is associated with diabetic neuropathy in type 1 diabetic Russian patients

Chistiakov, Dimitry A.; Zotova, Elena; Savost'anov, KV; Tr, Bursa; Galeev, I. V.; Строков, И. А.; Vv, Nosikov

doi:10.1016/s1262-3636(07)70248-3

Cited by 59 publications

(49 citation statements)

References 15 publications

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“…Secondary risk factors are smoking and prediabetes [1,21,60,63]. Platelet activation [79][80][81][82], oxidative stress [65][66][67][68][69][70][71][72][73][74], low vitamin D [83,84], insulin resistance [58], and genetic factors [100][101][102][103][104][105][106] play another supplementary role, but, for the time being, there are limited options for intervention. A suggestion for targeting insulin resistance originates from the study by Pop-Busui et al, showing that reduced incident DSPN is less frequent in T2D patients receiving insulin-sensitizing oral agents (66%) than in those receiving insulinproviding treatment (66% vs. 72%, respectively, p = 0.02) [155].…”

Section: Discussionmentioning

confidence: 99%

“…Na + /K + -ATPase may be influenced by metabolic control and C-peptide secretion [101]. Some single nucleotide polymorphisms (SNPs) have been studied in Russian T1D patients with DSPN: these relate to the poly(ADPribose)polymerase-1 gene, the catalase gene, and genes encoding the enzymes superoxide dismutase extracellular superoxide dismutase [102][103][104]. In Greek T2D patients, the D allele of the Alpha2B adrenoceptor has been found to be associated with presence and severity of DSPN [105].…”

Section: Genetic Factorsmentioning

confidence: 99%

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Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

2015

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■ AbstractDistal symmetric sensorimotor polyneuropathy (DSPN) is the most common neurological manifestation in diabetes. Major risk factors of DSPN include diabetes duration, hyperglycemia, and age, followed by prediabetes, hypertension, dyslipidemia, and obesity. Height, smoking, insulin resistance, hypoinsulinemia, and others represent an additional risk. Importantly, hyperglycemia, hypertension, dyslipidemia, obesity, and smoking are modifiable. Stringent glycemic control has been shown to be effective in type 1, but not to the same extent in type 2 diabetes. Antilipidemic treatment, especially with fenofibrate, and multi-factorial intervention have produced encouraging results, but more experience is necessary. The major comorbidities of DSPN are depression, autonomic neuropathy, peripheral artery disease, cardiovascular disease, nephropathy, retinopathy, and medial arterial calcification. Knowledge of risk factors and comorbidities has the potential to enrich the therapeutic strategy in clinical practice as part of the overall medical care for patients with neuropathy. This article provides an updated overview of DSPN risk factors and comorbidities.

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Section: Discussionmentioning

confidence: 99%

Section: Genetic Factorsmentioning

confidence: 99%

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

2015

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“…17 Moreover, several single nucleotide polymorphisms (SNPs) in the CAT gene have been found to be associated with diabetic nephropathy and neuropathy. 18,19 However, it is unknown whether there is an association between antioxidant gene polymorphisms and clinical outcomes of acute kidney injury (AKI). Therefore, in the current study, we studied the association between MnSOD, CAT and GPX1 gene polymorphisms and clinical outcomes of AKI.…”

Section: Introductionmentioning

confidence: 99%

Manganese superoxide dismutase, glutathione peroxidase and catalase gene polymorphisms and clinical outcomes in acute kidney injury

Kıdır

Yiğit

et al. 2016

Renal Failure

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Introduction The aim of this study was to evaluate the potential association of single gene polymorphisms of manganese superoxide dismutase (MnSOD), glutathione peroxidase 1 (GPX1) and catalase (CAT) with clinical outcomes of acute kidney injury (AKI). Materials and methods Ninety AKI patients and 101 healthy volunteers were included in the study. Determination of MnSOD rs4880, GPX1 rs1050450 and CAT rs769217 polymorphisms was performed using real-time polymerase chain reaction amplification. The duration of hospitalization of AKI patients, dialysis and intensive care requirements, sepsis, oliguria and in-hospital mortality rates were assessed. Results The MnSOD, GPX1 and CAT genotypes and allele frequencies of AKI patients did not differ significantly from those of healthy controls. In patients with a T allele in the ninth exon of the CAT gene, intensive care requirements were greater than those of patients with the CC genotype (p ¼ 0.04). In addition, sepsis and in-hospital mortality were observed significantly more frequently in patients with a T allele in the ninth exon of the CAT gene (p ¼ 0.03). Logistic regression analysis determined that bearing a T allele was the primary determinant of intensive care requirements and in-hospital mortality, independent of patient age, gender, presence of diabetes and dialysis requirements (OR 6.10, 95% CI 1.34-27.81, p ¼ 0.02 and OR 10.25, 95% CI 1.13-92.80, p ¼ 0.04, respectively). Conclusion Among AKI patients in the Turkish population, hospital morbidity and mortality were found to be more frequent in patients bearing a T allele of the rs769217 polymorphism of the CAT gene.

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“…A microsatellite polymorphism (D11S2008) of the CAT gene region has been identified, closely linked to the CAT gene on chromosome 11p13, including a CTAT repeat array [23,24]. The microsatellite polymorphism studied in the patients with T1DM from the D11S2008 CAT gene region has been weakly associated with coronary heart disease and blood pressure levels in patients with T2DM [23].…”

Section: Introductionmentioning

confidence: 99%