2008
DOI: 10.1016/j.jmb.2008.01.038
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The 3′ Ends of Mature Transcripts Are Generated by a Processosome Complex in Fission Yeast Mitochondria

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Cited by 31 publications
(30 citation statements)
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“…We then compared the genes that were differentially expressed in response to antimycin A (Additional file 1: Table S4) to the genes that were differentially expressed in two different respiratory-deficient mutants, rpm1 [52] and reb1 (M. R.-L., unpublished data). Rpm1 is a mitochondrial RNA exonuclease involved in the processing and degradation of mitochondrial transcripts [53]; its deletion therefore abolishes production of mitochondrial-encoded ETC subunits (the rpm1 deletion was not present in our mutant libraries for the genetic screens). Reb1 is a RNA polymerase I transcription termination protein that also functions as a transcription factor [54].…”
Section: Resultsmentioning
confidence: 99%
“…We then compared the genes that were differentially expressed in response to antimycin A (Additional file 1: Table S4) to the genes that were differentially expressed in two different respiratory-deficient mutants, rpm1 [52] and reb1 (M. R.-L., unpublished data). Rpm1 is a mitochondrial RNA exonuclease involved in the processing and degradation of mitochondrial transcripts [53]; its deletion therefore abolishes production of mitochondrial-encoded ETC subunits (the rpm1 deletion was not present in our mutant libraries for the genetic screens). Reb1 is a RNA polymerase I transcription termination protein that also functions as a transcription factor [54].…”
Section: Resultsmentioning
confidence: 99%
“…rpm1 (also called par1 ) encodes a protein with a predicted exonuclease II domain that localizes to mitochondria [50], [51]. Rpm1 is essential for growth in non-fermentable carbon sources, and rpm1Δ cells are defective in the processing of mitochondrially-encoded transcripts that encode key components of the respiratory chain, resulting in the accumulation of their RNA precursors [50].…”
Section: Resultsmentioning
confidence: 99%
“…Rpm1 is essential for growth in non-fermentable carbon sources, and rpm1Δ cells are defective in the processing of mitochondrially-encoded transcripts that encode key components of the respiratory chain, resulting in the accumulation of their RNA precursors [50]. rpm1 deletion caused reduced expression of a set of 38 nuclear-encoded genes, most of which encoded proteins localized to the mitochondrial envelope, including multiple components of the F0 and F1 ATPases and the cytochrome c oxidase complex (Figure 2E).…”
Section: Resultsmentioning
confidence: 99%
“…Also, the 3' UTRs of fission yeast mt-mRNAs are very short and cannot include obvious binding sites for a specific factor, since they already contain a C-rich motif that has been proposed to be the target of a general 3' processing complex. 14 The Ppr1 binding sites within the cox2 and cox3 mRNAs might correspond to a common or rather similar sequence and the identification of this sequence would be a significant step toward understanding the binding parameters of fission yeast PPR proteins.…”
Section: Principal Steps Of Mitochondrial Gene Expression Affected Bymentioning
confidence: 99%