Encyclopedia of Life Sciences 2018
DOI: 10.1002/9780470015902.a0027958
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The 3′ UTR Landscape in Cancer

Abstract: Oncogenesis is tightly connected with dysregulated gene expression. Alterations occur at many levels, including in posttranscriptional regulatory elements that control the stability, cellular localisation or translation efficiency of messenger ribonucleic acids (mRNAs). These elements are located primarily in the 3′ untranslated region (UTR) of mRNAs. Multiple examples are known of oncogenes whose activity and function become altered owing to changes in their 3′ UTRs. Strikingly, recent studies have uncovered … Show more

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Cited by 3 publications
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“…The remodeling of gene expression in cancers involves, among other processes, alternative polyadenylation. A tendency toward 3' UTR shortening has been generally observed, though to different extents, in virtually all studied cancers (Schmidt et al, 2018;Xia et al, 2014).…”
Section: Discussionmentioning
confidence: 82%
“…The remodeling of gene expression in cancers involves, among other processes, alternative polyadenylation. A tendency toward 3' UTR shortening has been generally observed, though to different extents, in virtually all studied cancers (Schmidt et al, 2018;Xia et al, 2014).…”
Section: Discussionmentioning
confidence: 82%