The 3′UTR 1188A/C polymorphism of IL-12p40 is not associated with susceptibility for developing plaque psoriasis in Mestizo population from western Mexico

Sandoval-Talamantes, Ana Karen; Brito-Luna, M.J.; Fafutis‐Morris, Mary; Villanueva-Quintero, Delfina Guadalupe; Graciano-Machuca, Omar; Ramírez‐Dueñas, Maria Guadalupe; Alvarado-Navarro, Anabell

doi:10.1016/j.imlet.2014.10.004

Cited by 7 publications

(2 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genome-wide association and linkage-based studies have identified several psoriasis susceptibility regions (PSORS) predisposing to the disease [ 1 , 5 – 9 ]. However, many of them failed to be replicated in other populations, except HLA-Cw6 allele in patients with age of disease onset below 40 years [ 10 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

Epigenome-wide DNA methylation regulates cardinal pathological features of psoriasis

Chandra

Senapati

Roy³

et al. 2018

Clin Epigenet

View full text Add to dashboard Cite

BackgroundPsoriasis is a chronic inflammatory autoimmune skin disorder. Several studies suggested psoriasis to be a complex multifactorial disease, but the exact triggering factor is yet to be determined. Evidences suggest that in addition to genetic factors, epigenetic reprogramming is also involved in psoriasis development. Major histopathological features, like increased proliferation and abnormal differentiation of keratinocytes, and immune cell infiltrations are characteristic marks of psoriatic skin lesions. Following therapy, histopathological features as well as aberrant DNA methylation reversed to normal levels. To understand the role of DNA methylation in regulating these crucial histopathologic features, we investigated the genome-wide DNA methylation profile of psoriasis patients with different histopathological features.ResultsGenome-wide DNA methylation profiling of psoriatic and adjacent normal skin tissues identified several novel differentially methylated regions associated with psoriasis. Differentially methylated CpGs were significantly enriched in several psoriasis susceptibility (PSORS) regions and epigenetically regulated the expression of key pathogenic genes, even with low-CpG promoters. Top differentially methylated genes overlapped with PSORS regions including S100A9, SELENBP1, CARD14, KAZN and PTPN22 showed inverse correlation between methylation and gene expression. We identified differentially methylated genes associated with characteristic histopathological features in psoriasis. Psoriatic skin with Munro’s microabscess, a distinctive feature in psoriasis including parakeratosis and neutrophil accumulation at the stratum corneum, was enriched with differentially methylated genes involved in neutrophil chemotaxis. Rete peg elongation and focal hypergranulosis were also associated with epigenetically regulated genes, supporting the reversible nature of these characteristic features during remission and relapse of the lesions.ConclusionOur study, for the first time, indicated the possible involvement of DNA methylation in regulating the cardinal pathophysiological features in psoriasis. Common genes involved in regulation of these pathologies may be used to develop drugs for better clinical management of psoriasis.Electronic supplementary materialThe online version of this article (10.1186/s13148-018-0541-9) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

Epigenome-wide DNA methylation regulates cardinal pathological features of psoriasis

Chandra

Senapati

Roy³

et al. 2018

Clin Epigenet

View full text Add to dashboard Cite

show abstract

“…No significant phenotype variations between patients of different ages were found, but a correlation was identified between the genes IFIH1 and ERAP1 and the severity of the disease [57]. Another study performed in Mexican Mestizo population from western Mexico showed that there is no correlation between the SNPrs3212227 (identified in the IL-12B gene), the susceptibility to develop plaque psoriasis and levels of IL-12 and IL-23 in serum [58]. The age and the sex of the patients have no significant influence in genetic aspects of the plaque psoriasis [50].…”

Section: Genotype-phenotype Correlationsmentioning

confidence: 96%

Plaque Psoriasis: Understanding Risk Factors of This Inflammatory Skin Pathology

Bélanger¹,

Oliveira²,

Maheux³

et al. 2016

JCDSA

View full text Add to dashboard Cite

Covering the entire human body, the skin is considered to be one of the most important organs, since it is the first line of protection against chemical and biological external agents. Although the skin protects tissues and organs against external aggression, it can still be unbalanced by various skin diseases, such as psoriasis. This non-contagious inflammatory dermatosis is characterized by the occurrence of erythematous lesions of various sizes covered with whitish scales. This scaling of the skin is the result of a rapid renewal of the epidermis, occurring over five to seven days instead of 28 days. Psoriasis vulgaris, or plaque psoriasis, is the most common form of this disease and is therefore commonly referred to by the term "psoriasis". This work is a review of the literature on plaque psoriasis, aiming at a better comprehension of the pathology at the histological level, but also to understand the genetic and environmental factors associated with this inflammatory dermatosis.

show abstract

Correlation of IL-12, IL-22, and IL-23 in patients with psoriasis and metabolic syndrome. Preliminary report

Brito-Luna¹,

Villanueva-Quintero²,

Sandoval-Talamantes

et al. 2016

Cytokine

View full text Add to dashboard Cite

The 3′UTR 1188A/C polymorphism of IL-12p40 is not associated with susceptibility for developing plaque psoriasis in Mestizo population from western Mexico

Cited by 7 publications

References 64 publications

Epigenome-wide DNA methylation regulates cardinal pathological features of psoriasis

Epigenome-wide DNA methylation regulates cardinal pathological features of psoriasis

Plaque Psoriasis: Understanding Risk Factors of This Inflammatory Skin Pathology

Correlation of IL-12, IL-22, and IL-23 in patients with psoriasis and metabolic syndrome. Preliminary report

Contact Info

Product

Resources

About