The 30-item and 15-item Boston naming test Czech version: Item response analysis and normative values for healthy older adults

Bezdíček, Ondřej; Rosická, Anna Marie; Mana, Josef; Libon, David J.; Kopeček, Miloslav; Georgi, Hana

doi:10.1080/13803395.2022.2029360

Cited by 11 publications

(8 citation statements)

References 89 publications

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“…Old subjects underwent neuropsychological assessment by an experienced neuropsychologist during a preliminary visit approximately two weeks before the MRI session. The assessments included two neuropsychological tests for each of the following domains: (1) Psychomotor speed and working memory: Trail Making Test, part A 41 and Digit span backwards from the Wechsler Adult Intelligence Scale, third revision (WAIS-III) 42 ; (2) Executive function: Tower of London 43 and semantic verbal fluency 44 ; (3) Language: Boston Naming Test, Czech version 45 , 46 and WAIS-III Similarities (Wechsler, 1997); (4) Long term memory: Rey Auditory Verbal Learning Test, delayed recall 47 and Brief Visuospatial Memory Test, revised, delayed recall 48 , 49 ; (5) Visuospatial function: CLOX 50 and Judgment of Line Orientation 51 . The score on each test was transformed into a z-score using the Rankit formula 52 .…”

Section: Methodsmentioning

confidence: 99%

Directed functional connectivity of the default-mode-network of young and older healthy subjects

Goelman,

Dan,

Bezdicek

et al. 2024

Sci Rep

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Alterations in the default mode network (DMN) are associated with aging. We assessed age-dependent changes of DMN interactions and correlations with a battery of neuropsychological tests, to understand the differences of DMN directed connectivity between young and older subjects. Using a novel multivariate analysis method on resting-state functional MRI data from fifty young and thirty-one healthy older subjects, we calculated intra- and inter-DMN 4-nodes directed pathways. For the old subject group, we calculated the partial correlations of inter-DMN pathways with: psychomotor speed and working memory, executive function, language, long-term memory and visuospatial function. Pathways connecting the DMN with visual and limbic regions in older subjects engaged at BOLD low frequency and involved the dorsal posterior cingulate cortex (PCC), whereas in young subjects, they were at high frequency and involved the ventral PCC. Pathways combining the sensorimotor (SM) cortex and the DMN, were SM efferent in the young subjects and SM afferent in the older subjects. Most DMN efferent pathways correlated with reduced speed and working memory. We suggest that the reduced sensorimotor efferent and the increased need to control such activities, cause a higher dependency on external versus internal cues thus suggesting how physical activity might slow aging.

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Section: Methodsmentioning

confidence: 99%

Directed functional connectivity of the default-mode-network of young and older healthy subjects

Goelman,

Dan,

Bezdicek

et al. 2024

Sci Rep

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“…The executive function was measured by the Tower of London ( Michalec et al, 2014 ) and by semantic verbal fluency ( Nikolai et al, 2015 ). Language was measured by the Boston Naming Test, Czech version ( Zemanová et al, 2016 ; Bezdicek et al, 2021 ) and WAIS-III Similarities ( Wechsler, 1997 ). The score on each test was transformed into a z-score using the Rankit formula ( Solomon and Sawilowsky, 2009 ).…”

Section: Methodsmentioning

confidence: 99%

Directed functional connectivity of the sensorimotor system in young and older individuals

Goelman,

Dan,

Bezdicek

et al. 2023

Front. Aging Neurosci.

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IntroductionStudies in the sensorimotor system of older versus young individuals have shown alterations in functional connectivity and organization. Our objective was to explore the implications of these differences in terms of local organizations, and to identify processes that correlate with neuropsychological parameters.MethodsUsing a novel multivariate analysis method on resting-state functional MRI data obtained from 50 young and 31 older healthy individuals, we identified directed 4-node functional pathways within the sensorimotor system and examined their correlations with neuropsychological assessments.ResultsIn young individuals, the functional pathways were unidirectional, flowing from the primary motor and sensory cortices to higher motor and visual regions. In older individuals, the functional pathways were more complex. They originated either from the calcarine sulcus or the insula and passed through mutually coupled high-order motor areas before reaching the primary sensory and motor cortices. Additionally, the pathways in older individuals that resembled those found in young individuals exhibited a positive correlation with years of education.DiscussionThe flow pattern of young individuals suggests efficient and fast information transfer. In contrast, the mutual coupling of high-order motor regions in older individuals suggests an inefficient and slow transfer, a less segregated and a more integrated organization. The differences in the number of sensorimotor pathways and of their directionality suggests reduced efferent degenerated pathways and increased afferent compensated pathways. Furthermore, the positive effect of years of education may be associated with the Cognitive Reserve Hypothesis, implying that cognitive reserve could be maintained through specific information transfer pathways.

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“…Participants underwent comprehensive neuropsychological testing to evaluate various domains of cognition after completing a standard clinical assessment. (i) The Mini-Mental State Examination (MMSE) (score range 0–30) was used to assess global cognitive function (Tombaugh and McIntyre, 1992 ); (ii) the Auditory Verbal Learning Test (AVLT) N5 was used to assess memory (score range 0–12) (Hawkins et al ., 2004 ); (iii) the Trail-Making Test B was used to assess executive function with scores depending on the number of seconds it took for the participant to complete the test (Tombaugh, 2004 ); (iv) the Boston Naming Test (BNT) was used to assess language function with scores ranging from 0–30 (Bezdicek et al ., 2021 ); and (v) the Symbolic Digit Transformation Test (SDMT) was used to assess information processing speed, with scores depending on the number of symbols recorded correctly within 90 s (Fellows and Schmitter-Edgecombe, 2019 ). Additionally, the 17-item Hamilton Depression Rating Scale (HAMD-17) was used to evaluate the severity of depression (Schwab et al ., 1967 ).…”

Section: Methodsmentioning

confidence: 99%

Differences in olfactory functional connectivity in early-onset depression and late-onset depression

Chen,

Yang,

Liu

et al. 2023

Psychoradiology

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Background Late-onset depression (LOD) and early-onset depression (EOD) exhibit different pathological mechanisms and clinical phenotypes, including different extents of olfactory dysfunction. However, the brain abnormalities underlying the differences in olfactory dysfunction between EOD and LOD remain unclear. Objective The aim of this study was to compare the functional connectivity (FC) patterns of olfactory regions between EOD patients and LOD patients and examine their relationship with cognitive function. Methods One hundred and five patients with EOD, 101 patients with LOD and 160 normal controls (NCs) were recruited for the present study. Participants underwent clinical assessment, olfactory testing, cognitive assessments, and magnetic resonance imaging. Eight regions of the primary and secondary olfactory regions were selected to investigate olfactory FC. Results Patients with LOD exhibited decreased odor identification (OI) compared with patients with EOD and NCs. The LOD group exhibited decreased FC compared with the EOD and NC groups when primary and secondary olfactory regions were selected as the regions of interest (the piriform cortex, lateral entorhinal cortex, and orbital-frontal cortex). Additionally, these abnormal olfactory FCs were associated with decreased cognitive function scores and OI, and the FC between the left orbital-frontal cortex and left amygdala was a partial mediator of the relationship between global cognitive scores and OI. Conclusion Overall, patients with LOD exhibited decreased FC in both the primary and secondary olfactory cortices compared with patients with EOD, and abnormal olfactory FC was associated with OI dysfunction and cognitive impairment. The FC between the orbital-frontal cortex and amygdala mediated the relationship between global cognitive function and OI.

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The 30-item and 15-item Boston naming test Czech version: Item response analysis and normative values for healthy older adults

Cited by 11 publications

References 89 publications

Directed functional connectivity of the default-mode-network of young and older healthy subjects

Directed functional connectivity of the default-mode-network of young and older healthy subjects

Directed functional connectivity of the sensorimotor system in young and older individuals

Differences in olfactory functional connectivity in early-onset depression and late-onset depression

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