The −308 G/A polymorphism in TNF-α gene is associated with asthma risk: an update by meta-analysis

Abstract

Our results suggest that the TNF-α -308 G/A polymorphism contributes to susceptibility to asthma.

Genetic Polymorphism of Transforming Growth Factor β1 and Tumor Necrosis Factor α Is Associated With Asthma and Modulates the Severity of Asthma

“…Our results support the recent meta-analysis showing the -308 G/A polymorphism in TNF-␣ gene to be associated with asthma risk. 30 In this meta-analysis study, subgroup analysis by ethnicity showed significant elevated risks for asthma to be associated with A allele carriers in Asians but not in whites. 30 These conflicting results may have arisen from a range of factors, such as racial/ethnic differences, linkage or case-control association study, sample size, and the strictness of the asthmatic enrolment by definite diagnosis.…”

“…30 In this meta-analysis study, subgroup analysis by ethnicity showed significant elevated risks for asthma to be associated with A allele carriers in Asians but not in whites. 30 These conflicting results may have arisen from a range of factors, such as racial/ethnic differences, linkage or case-control association study, sample size, and the strictness of the asthmatic enrolment by definite diagnosis. Asthmatic subjects in the present study were strictly enrolled based on clear diagnostic criteria, and were regularly followed up in our out-patient clinic.…”

Gene Polymorphisms of 22 Cytokines in Macedonian Children with Hyperimmunoglobulinemia E

“…It is necessary to investigate cytokine gene polymorphisms in our population in well defined subgroups of phenotypes with bigger number of participants in order to have more precise conclusions for genetic background of development of hyperimmunoglobulinemia E in Macedonians. However, multicentre studies and/or meta-analysis of the patients with hyperimmunoglobulinaemia E and association with cytokine polymorphisms should be very useful, as it was shown before with our published data about cytokine polymorphism associations [59][60][61].…”

Gene Expression in Chronic Fatigue Syndrome

“…TNFA expression increases in the presence of stress and this has been observed in CFS patients although this increase was similar in healthy controls (Light et al, 2009). While mRNA levels in TNFA may be similar in CFS and healthy controls, polymorphism within TNFA may affect their ability to perform efficiently as shown in other diseases (Zhang et al, 2010).…”