1992
DOI: 10.1073/pnas.89.21.10464
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The (4;11)(q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase.

Abstract: Chromosomal region 11q23 is frequently rearranged in acute lymphocytic leukemias (ALLs) and in acute myeloid leukemlas (AMLs), mostly In reciprocal ex n with various transocation partners. The most of these translocations is t(4;11)(q21;q23). It Is present in -10% ofALL patients, most frequently in very young children. We have recently cloned a region of chromosome 11, the ALL-i locus, found to be rearranged in maligant cells from patients with the t(4;11), t(9;11),) t(11;19)9 t(1;11), t(6;11)9 t(10;11)9 and d… Show more

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Cited by 88 publications
(47 citation statements)
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“…The absolute lymphocyte count inversely correlated with current but not with cumulative exposure, which was expected because peripheral white blood cell counts decline within several months of initial contact with high levels of benzene and generally return to baseline after benzene levels are reduced below hematotoxic levels (26,27). (29) and some leukemias (30). Because these translocations appear to be centrally involved in the development of the leukemic phenotype, further investigation of the ability of benzene and its metabolites to induce recombination is warranted.…”
Section: Discussionmentioning
confidence: 99%
“…The absolute lymphocyte count inversely correlated with current but not with cumulative exposure, which was expected because peripheral white blood cell counts decline within several months of initial contact with high levels of benzene and generally return to baseline after benzene levels are reduced below hematotoxic levels (26,27). (29) and some leukemias (30). Because these translocations appear to be centrally involved in the development of the leukemic phenotype, further investigation of the ability of benzene and its metabolites to induce recombination is warranted.…”
Section: Discussionmentioning
confidence: 99%
“…These included homologous interchromosomal Alu-Alu recombination (Chen et al, 1989;Onno et al, 1992), recombination by the machinery of the immune system (Haluska et al, 1990;Gu et al, 1992b), and recombination subsequent to the inhibition of topoisomerase II (Negrini et al, 1993;Aplan et al, 1996). None of our cases showed evidence for Alu-Alu recombination.…”
Section: Observations Excluding Other Potential Mechanisms Of Recombimentioning
confidence: 99%
“…Gu and colleagues noted nucleotide sequences that resembled heptamer and nonamer sequences near the t(4;11) breakpoints in two cell lines derived from patients with B-cell precursor ALL and MLL translocations [38]. They proposed that the VDJ recombination machinery may have been directly involved in the genesis of these translocations.…”
Section: Aberrant Vdj Recombinationmentioning
confidence: 99%