The 5-hydroxytryptamine receptor type 4 regulates blood-brain-barrier permeability

Becker, Guillaume; Silva, S. Da; Sabo, Amelia-Naomi; Kemmel, Véronique; Monassier, Laurent

doi:10.1016/j.acvdsp.2021.04.093

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2022

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“…Prucalopride has been shown to permeate into the CNS in rat models, supporting a potential neurobiological mechanism for psychotropic effects 2 . More recently, prucalopride has been shown to increase the permeability of the blood–brain barrier in a model using human cerebral microvascular endothelial cells 3 …”

Section: Discussionmentioning

confidence: 90%

“…2 More recently, prucalopride has been shown to increase the permeability of the blood-brain barrier in a model using human cerebral microvascular endothelial cells. 3 Pre-clinical studies have also implicated the 5-HT4 receptor in mood disorders such as depression using murine models. Rats treated with prucalopride have been shown to spend less time immobile and greater time climbing in a forced swimming test (FST), showing no statistical difference in performance compared to rats treated with citalopram.…”

Section: Discussionmentioning

confidence: 99%

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