1987
DOI: 10.1016/0092-8674(87)90359-x
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The 5S gene internal control region is composed of three distinct sequence elements, organized as two functional domains with variable spacing

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Cited by 195 publications
(131 citation statements)
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“…In yeast cells, for example, there is synergistic binding of transcription factors al and PRTF (7) and of HAP1 and A2 (39) to juxtaposed binding sites in the STE3 and CYC7 promoters, respectively. In other eucaryotic systems, synergistic binding has been observed for AP-2 and SP1 in the simian virus 40 early promoter (34) and for TFIIIA and TFIIIC in Xenopus laevis 5S RNA genes (38). Is there genetic evidence for such a factor in ADH2 regulation?…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In yeast cells, for example, there is synergistic binding of transcription factors al and PRTF (7) and of HAP1 and A2 (39) to juxtaposed binding sites in the STE3 and CYC7 promoters, respectively. In other eucaryotic systems, synergistic binding has been observed for AP-2 and SP1 in the simian virus 40 early promoter (34) and for TFIIIA and TFIIIC in Xenopus laevis 5S RNA genes (38). Is there genetic evidence for such a factor in ADH2 regulation?…”
Section: Discussionmentioning
confidence: 99%
“…Consistent with this observation, ADR1 did not form a detectable complex with UAS2. Deletion of UAS2 at the chromosomal ADH2 locus virtually abolished ADH2 derepression and had no effect on glucose repression.Recent studies indicate that eucaryotic gene regulation often involves the coordinate interaction of multiple transcription factors (4,7,34,(36)(37)(38)(39). These trans-acting proteins may regulate several genes which function in separate pathways (4, 7).…”
mentioning
confidence: 99%
“…As some ICRs coincided with the primerannealing regions, some sequences were excluded from the comparisons, and sequences amplified with the 5S-Univ primers (Table 2) Pieler et al (1987) in Xenopus laevis, obtaining 6/12, 6/10 and 12/18 matches. Within razor shells, the matches obtained were 9/12, 7/10 and 14/18.…”
Section: Upstream Elementsmentioning
confidence: 99%
“…7). By sequence comparison with the well-characterized Xenopus model (Pieler et al 1987), the intermediate element (one of the three boxes from the internal promoter) is between positions 67 and 72. Nearly all the 5S units from the chromosome 5 minor block (96%) have mutations at position 70A, 71T, and 72T, which could participate to the transcription inhibition or to the recognition by the degradation mechanism.…”
Section: Chromosome 5 Minor Blockmentioning
confidence: 99%