The −67 A/T promoter polymorphism in the dopamine transporter gene affects personality traits of Japanese healthy females

Shibuya, Naoshi; Kamata, Mitsuhiro; Suzuki, Akihito; Matsumoto, Yoshihiko; Goto, Kaoru; Otani, Koichi

doi:10.1016/j.bbr.2009.04.008

Cited by 11 publications

(19 citation statements)

References 33 publications

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“…Our negative results are similar to the findings in healthy Korean and Japanese volunteers (Kim et al, 2006;Shibuya et al, 2009), while the results of Kazantseva et al (2011) suggested that the 3 VNTR and rs27072 of DAT1 are associated with the persistence in healthy Caucasian individuals. We used the TPQ and 18 DAT1 polymorphisms to assess gene-personality interactions in both healthy individuals and AD patients, whereas previous studies (Kazantseva et al, 2011;Kim et al, 2006;Shibuya et al, 2009) used the Temperament and Character Inventory and rare polymorphisms to evaluate healthy individuals. Conflicting findings should therefore be interpreted cautiously because of the different assessment tools used for different populations and diverse subjects.…”

Section: Dat1 Genetic Variants In Different Personality Traitssupporting

confidence: 93%

“…Comparison of the allele frequencies of DAT1 in different populations showed that the minor allele frequency of promoter and 3 VNTR polymorphisms are lower in Asians than in European Caucasian and Brazilian populations (de Azeredo et al, 2014;Huang et al, 2010;Shibuya et al, 2009;Vereczkei et al, 2013). These differences may influence the effect of DAT1 on the development of AD and on personality traits.…”

Section: Variantsmentioning

confidence: 88%

“…The DAT1 gene was reported to effect personality traits in healthy controls (Kazantseva et al, 2011;Shibuya et al, 2009) and patients with mood disorder (Huang et al, 2011;Joyce et al, 2009), but there are no available data of personality-gene interactions in AD patients. The present study assessed the personality traits of AD patients using the Tridimensional Personality Questionnaire (TPQ) to determine whether specific personality and gene-personality interactions are involved in the pathogenesis of AD.…”

Section: Introductionmentioning

confidence: 99%

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The dopamine transporter gene may not contribute to susceptibility and the specific personality traits of amphetamine dependence

Tzeng

Yeh

et al. 2015

Drug and Alcohol Dependence

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Section: Dat1 Genetic Variants In Different Personality Traitssupporting

confidence: 93%

Section: Variantsmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The dopamine transporter gene may not contribute to susceptibility and the specific personality traits of amphetamine dependence

Tzeng

Yeh

et al. 2015

Drug and Alcohol Dependence

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“…Exploring the molecular basis of personality dimensions has been the focus of numerous genetic association studies (11)(12)(13)(14). The dopaminergic system has been suggested to play a role not only in personality pathologies but also in depression (15).…”

Section: Introductionmentioning

confidence: 99%

The dopamine transporter gene possibly affects personality traits in patients with early-onset major depressive disorder

Huang

Shih

et al. 2013

Acta Neuropsychiatr.

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“…Temperament as measured with TCI was hypothesized to be determined genetically and correlated with dopaminergic, serotonergic and noradrenergic activity [13] , although there is some controversy about this claim [14][15][16][17][18] . Some psychopathological studies have reported that TCI traits are associated with major depressive disorder [19] , minor affective psychopathology [20] and regular use of psychotropic medication [20] .…”

Section: Introductionmentioning

confidence: 99%

Six-Year Stability of Affective Temperaments as Measured by TEMPS-A

Kawamura¹,

Akiyama

Shimada³

et al. 2010

Psychopathology

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Background: A number of psychopathological and neurobiological studies on affective temperament have been conducted based on the assumption that temperament is a stable trait. However, few studies have actually assessed the long-term stability of affective temperament. The objective of this study is to evaluate the 6-year stability of affective temperaments as measured by the Temperament Evaluation of Memphis, Pisa, Paris and San Diego – Autoquestionnaire version (TEMPS-A) in a non-clinical adult population. Sampling and Methods: Study participants consisted of 178 Japanese white-collar workers (103 males and 75 females; mean age = 38.5 years, SD = 7.8) who completed the Japanese version of TEMPS-A twice over a 6-year interval, and who did not have either past or current DSM-IV affective, anxiety or psychotic disorders, as diagnosed with the Mini-International Neuropsychiatric Interview. The long-term stability of affective temperaments as measured by TEMPS-A was assessed by analyzing Pearson correlation coefficients for temperament scores over a 6-year period. Results: Temperament scores were moderately to highly correlated over the 6-year period (depressive temperament, r = 0.59; cyclothymic temperament, r = 0.68; hyperthymic temperament, r = 0.82; irritable temperament, r = 0.66; anxious temperament, r = 0.74; p < 0.01 for all values). Pearson coefficients were in the range of 0.61–0.83 for males and 0.51–0.79 for females, while they were 0.56–0.85 for younger and 0.63–0.77 for older participants. All correlations were significant at p < 0.01, irrespective of temperament type, gender and age. Conclusions: Affective temperaments as measured by TEMPS-A exhibited good long-term stability and were robust, irrespective of temperament type, gender and age. Affective temperaments as measured by TEMPS-A may be considered to be stable traits, providing a sound basis for psychopathological and neurobiological studies. Limitations of this study include the fact that our sample was not drawn from the general community, it was entirely composed of Japanese participants and the size was not large.

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The −67 A/T promoter polymorphism in the dopamine transporter gene affects personality traits of Japanese healthy females

Cited by 11 publications

References 33 publications

The dopamine transporter gene may not contribute to susceptibility and the specific personality traits of amphetamine dependence

The dopamine transporter gene may not contribute to susceptibility and the specific personality traits of amphetamine dependence

The dopamine transporter gene possibly affects personality traits in patients with early-onset major depressive disorder

Six-Year Stability of Affective Temperaments as Measured by TEMPS-A

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