The 95ΔG mutation in the 5′untranslated region of the norA gene increases efflux activity in Staphylococcus epidermidis isolates

García-Gómez, Elizabeth; Jaso-Vera, Marcos Emmanuel; Juárez-Verdayes, Marco A.; Alcántar‐Curiel, María Dolores; Zenteno, Juan Carlos; Betanzos‐Cabrera, Gabriel; Peralta, Humberto; Rodríguez‐Martínez, Sandra; Cancino-Díaz, Mario E.; Jan‐Roblero, Janet; Cancino‐Díaz, Juan C.

doi:10.1016/j.micpath.2016.12.021

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2017

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“…Target site mutations have been described [6]. Active efflux, as suggested by blocking by reserpine, contributes substantially to the resistance phenotype in some strains of CoNS [7],[8], and role of efflux overexpression of a mutation in an untraslated sequence before norA -like gene [9].…”

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confidence: 99%

Intrinsic role of coagulase negative staphylococci <em>norA</em>-like efflux system in fluoroquinolones resistance

et al. 2017

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NorA is a Staphylococcus aureus multidrug transporter that exports structurally distinct compounds including fluoroquinolones. In this study norA- like genes of Staphylococcus epidermidis ( norA SEP ) and Staphylococcus haemolyticus ( norA SHAE ) were identified and sequenced. The nucleotide identity of norA SEP and norA SHAE with norA was 75.3 and 74.1%, respectively, and the amino acid identity 87.7 and 86%, respectively. Inactivation of norA SEP increased the ciprofloxacin susceptibility of E. coli DH5α carrying the pB SK 198 norA SEP EZ cat norA SEP plasmid.

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