Despite greater awareness that the American population and workforce are increasingly diverse, there is little appreciation for the persistent and discrepant effect of difference on the lived experiences of social outsider groups. Consistent with a history of preference for able-bodied, well off, White, mature, heterosexual, males, for example, most U.S. institutions continue to be hegemonic. Proffering a road map for managing diversity and equalizing life chances across multiple spaces, this paper articulates an innovative conceptual framework called ACRASH. This powerful analogy and acronym (for ableism, classism, racism, ageism, sexism, and heterosexism) denotes the primary dimensions of difference that spawn discrimination, harassment, and prejudice and shape disparate realities for Americans. As well, attention calling, perpetual proportionate affirmative action, and the use of a progressive syntax are posited as effective means for improved relations and the development of more positive socioeconomic and political outcomes in the U.S. and, perhaps, beyond.