The ABCs of MHC

Knapp, Leslie A.

doi:10.1002/evan.20038

Cited by 32 publications

(21 citation statements)

References 85 publications

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“…Higher expression of these genes was also observed in testis, spermatozoa and ovary in buffalo. This is in accordance with earlier studies reporting the presence of cells expressing class II MHC molecules within the mice corpus luteum indicating their roles in reproduction, mate selection, pregnancy maintenance and fertility [43, 44]. …”

Section: Discussionsupporting

confidence: 93%

Major Histocompatibility Complex Dmα/β Genes and Their Expressional Diversity in Healthy and Diseased Water Buffalo Bubalus bubalis

Rawal

Panwar

Ali

2018

Cell Physiol Biochem

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Background/Aims: The major histocompatibility complex (MHC) categorized into three (I, II and III) classes elicits the immunogenic response by presenting exogenous peptides to T cells. The MHC-II DM is composed of DMα and DMβ, two polypeptide chains, both are encoded by separate MHC genes involved in antigen processing and presentation. Despite the acknowledged role of MHC complex in humans, the literature is silent on the organization and expression of these genes in water buffalo Bubalus bubalis, an agriculturally important animal species. Methods: We deduced the full-length mRNA sequences of DMα and DMβ genes, localized them onto the chromosome 2, assessed their copy number per haploid genome and studied tissue and disease specific expression. Results: The Real Time PCR showed higher expression of both the genes and their seven interacting partners in spleen, gonads and spermatozoa. Significantly, upregulation of DMα and DMβ genes and their interacting partners were detected in diseased group of buffaloes as compared to that in healthy ones. Conclusion: The upregulation of Bubalus bubalis (BuLA)-DMα and DMβ genes and their interacting partners reflect their role in regulating immune responses towards the amelioration of diseases. Work on this line would enhance our understanding on the overall roles of MHC locus, allowing development of possible therapeutic treatment strategies.

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Section: Discussionsupporting

confidence: 93%

Major Histocompatibility Complex Dmα/β Genes and Their Expressional Diversity in Healthy and Diseased Water Buffalo Bubalus bubalis

Rawal

Panwar

Ali

2018

Cell Physiol Biochem

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“…obs.). Information from non neutral genes may help determine if the reduction in neutral diversity seen here is consistent with inbreeding depression (e.g., the Major Histocompatibility Complex (MHC); Knapp ; Radwan et al. ).…”

Section: Discussionmentioning

confidence: 97%

Population genetic patterns among social groups of the endangered Central American spider monkey (Ateles geoffroyi) in a human‐dominated landscape

Hagell

Whipple

Chambers

2013

Ecology and Evolution

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Spider monkeys (Genus: Ateles) are a widespread Neotropical primate with a highly plastic socioecological strategy. However, the Central American species, Ateles geoffroyi, was recently re-listed as endangered due to the accelerated loss of forest across the subcontinent. There is inconsistent evidence that spider monkey populations could persist when actively protected, but their long-term viability in unprotected, human-dominated landscapes is not known. We analyzed noninvasive genetic samples from 185 individuals in 14 putative social groups on the Rivas Isthmus in southwestern Nicaragua. We found evidence of weak but significant genetic structure in the mitochondrial control region and in eight nuclear microsatellite loci plus negative spatial autocorrelation in Fst and kinship. The overall pattern suggests strong localized mating and at least historical female-biased dispersal, as is expected for this species. Heterozygosity was significantly lower than expected under random mating and lower than that found in other spider monkey populations, possibly reflecting a recent decline in genetic diversity and a threat from inbreeding. We conclude that despite a long history of human disturbance on this landscape, spider monkeys were until recently successful at maintaining gene flow. We consider the recent decline to be further indication of accelerated anthropogenic disturbance, but also of an opportunity to conserve native biodiversity. Spider monkeys are one of many wildlife species in Central America that is threatened by land cover change, and an apt example of how landscape-scale conservation planning could be used to ensure long-term persistence.

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“…For example, frequent duplications mean that genes are often found in multiple, tightly linked copies, so that singlelocus amplification is impossible [79]. Separating sequences after multiple-locus amplification can be costly and time consuming and usually requires high-quality DNA extracted from blood or tissue [80]. Invasive sampling of large numbers of study subjects raises logistic and ethical problems.…”

Section: Technical Challenges and Outstanding Questions Overcoming Tementioning

confidence: 99%

The hidden benefits of sex: Evidence for MHC‐associated mate choice in primate societies

Setchell

Huchard

2010

BioEssays

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Major histocompatibility complex (MHC)-associated mate choice is thought to give offspring a fitness advantage through disease resistance. Primates offer a unique opportunity to understand MHC-associated mate choice within our own zoological order, while their social diversity provides an exceptional setting to examine the genetic determinants and consequences of mate choice in animal societies. Although mate choice is constrained by social context, increasing evidence shows that MHCdependent mate choice occurs across the order in a variety of socio-sexual systems and favours mates with dissimilar, diverse or specific genotypes non-exclusively. Recent research has also identified phenotypic indicators of MHC quality. Moreover, novel findings rehabilitate the importance of olfactory cues in signalling MHC genes and influencing primate mating decisions. These findings underline the importance to females of selecting a sexual partner of high genetic quality, as well as the generality of the role of MHC genes in sexual selection.

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The ABCs of MHC

Cited by 32 publications

References 85 publications

Major Histocompatibility Complex Dmα/β Genes and Their Expressional Diversity in Healthy and Diseased Water Buffalo Bubalus bubalis

Major Histocompatibility Complex Dmα/β Genes and Their Expressional Diversity in Healthy and Diseased Water Buffalo Bubalus bubalis

Population genetic patterns among social groups of the endangered Central American spider monkey (Ateles geoffroyi) in a human‐dominated landscape

The hidden benefits of sex: Evidence for MHC‐associated mate choice in primate societies

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