The Abdominal Constriction Response and Its Suppression by Analgesic Drugs in the Mouse

Collier, H. O. J.; Dinneen, L. C.; Johnson, Christine A.; Schneider, C

doi:10.1111/j.1476-5381.1968.tb00973.x

Cited by 1,043 publications

(796 citation statements)

References 25 publications

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“…Os modelos de nocicepção empregados envolvem diferentes mecanismos da dor, tais como o sistema simpático com liberação de aminas bioativas, os metabólitos da via do ácido araquidônico (Duarte et al, 1992) e o sistema opióide (Collier et al, 1968). O ácido acético age induzindo a liberação de mediadores endógenos que estimulam os nociceptores que são sensíveis aos antiinfl amatórios não-esteróides e/ou opióides (Collier et al, 1968).…”

Section: Discussionunclassified

Investigação das atividades analgésica e antiinflamatória do extrato metanólico dos rizomas de Echinodorus grandiflorus

Dutra¹,

Tavares²,

Ferraz³

et al. 2006

Rev. bras. farmacogn.

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RESUMO:O presente trabalho investigou as atividades analgésica e antiinfl amatória do extrato metanólico de rizomas de Echinodorus grandifl orus. Para isto, foram realizados os testes de contorções abdominais induzidas por ácido acético; tempo da lambida da pata induzida por formalina; edema de pata e pleurisia induzidas por carragenina. As doses de 100, 200 e 400 mg/kg inibiram as contorções em 34,30%, 35,84% e 36,07%, respectivamente. O tempo de lambida da primeira fase foi reduzido nas doses de 200 e 400 mg/kg, enquanto a segunda fase teve redução em 400 mg/kg. As doses testadas diminuíram o edema, enquanto o volume do exsudato foi reduzido em 24,61% na dose de 400 mg/kg. As doses de 200 e 400 mg/kg diminuíram a migração leucocitária. Os resultados indicam que o extrato de E. grandifl orus testado pode constituir alvo potencial para uso em terapias da dor e da infl amação. Unitermos:Echinodorus grandifl orus, atividade analgésica, atividade antiinfl amatória.ABSTRACT: "Investigation of analgesic and anti-infl ammatory activities of Echinodorus grandifl orus rhizomes methanol extract". The present work investigated the analgesic and antiinfl ammatory activities of the methanol extract of the rhizomes of Echinodorus grandifl orus. For this purpose, acetic acid writhing, paw licking induced by formalin, carrageenan-induced rat paw edema and pleurisy tests were performed. The doses of 100, 200 and 400 mg/kg inhibited the contortions 34.30%, 35.84% and 36.07%, respectively. The lick of the paw 1st phase was reduced at the doses of 200 and 400 mg/kg, while the 2nd phase had reduction at 400 mg/kg. All doses inhibited the paw edema, while the volume of the exsudate was reduced 24.61% in the dose of 400 mg/kg. The doses of 200 and 400 mg/kg decreased the leukocytes migration. The results indicate that the methanol extract of E. grandifl orus can constitute target potential for use in therapies of the pain and infl ammation.

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Section: Discussionunclassified

Investigação das atividades analgésica e antiinflamatória do extrato metanólico dos rizomas de Echinodorus grandiflorus

Dutra¹,

Tavares²,

Ferraz³

et al. 2006

Rev. bras. farmacogn.

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“…The first characteristic is quite important for investigating the contribution of the peripheral neurons to the nociceptive behavior. The use of the classical acetic acid writhing (36) or formalin (37) test does not permit the direct determination of the contribution of nociceptor sensitization to the overall nociceptive behavior. In contrast, this is a straightforward procedure with mechanical tests applied to paws pretreated with phlogogenic substances or inflammatory mediators.…”

Section: Discussionmentioning

confidence: 99%

An electronic pressure-meter nociception paw test for rats

Vivancos

Verri

Cunha

et al. 2004

Braz J Med Biol Res

201

118

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The objective of the present investigation was to compare the sensitivity of an electronic nociceptive mechanical paw test with classical mechanical tests to quantify the intensity variation of inflammatory nociception. The electronic pressure-meter test consists of inducing the hindpaw flexion reflex by poking the plantar region with a polypropylene pipette tip adapted to a hand-held force transducer. This method was compared with the classical von Frey filaments test and with the rat paw constant pressure test, a modification of the Randall and Selitto test developed by our group. When comparing the three methods, the electronic pressure-meter and the rat paw constant pressure test, but not the von Frey filaments test, detected time vs treatment interactions in prostaglandin E 2 (PGE 2 )-induced hypernociception. Both methods also detected the PGE 2 -induced hypernociception in dose-(50-400 ng/ paw) and time-(1-4 h) dependent manners, and time vs treatment interactions induced by carrageenin (25-400 µg/paw). Furthermore, the electronic pressure-meter test was more sensitive at early times, whereas the constant pressure test was more sensitive at later times. Moreover, the electronic pressure-meter test detected the dose-dependent antinociceptive effect of local indomethacin (30-300 µg/paw) and dipyrone (80-320 µg/paw) on carrageenin-(200 µg/paw) and PGE 2 -(100 ng/paw) induced hypernociception, respectively, and also detected the ineffectiveness of indomethacin (300 µg) on the effect of PGE 2 . Our results show that the electronic pressure-meter provides a sensitive, objective and quantitative mechanical nociceptive test that could be useful to characterize new nociceptive inflammatory mediators and also to evaluate new peripheral analgesic substances. Correspondence

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“…anticholinergic and antihistaminic and other agents show activity in this assay), but it is frequently used for analgesic screening and involves local peritoneal receptors (cholinergic and histamine receptor) and acetylcholine and histamine mediators (Calixto et al, 2000;Choi et al, 2003). The acetic acid model is generally used to evaluate the action of peripheral drugs, acting indirectly by inducing the release of endogenous mediators, which stimulate nociceptive neurons that are sensitive to non-steroidal anti-inflammatory drugs and/ or opioids (Collier et al, 1968).…”

Section: Discussionmentioning

confidence: 99%

“…Abdominal constriction was induced by intraperitoneal injection of acetic acid (0.6%), according to the procedure described previously (Collier et al, 1968) with minor modifications. Male Swiss mice (25-30 g) were pre-treated with extracts (3-20 mg/kg), intraperitoneally (i.p.…”

Section: Abdominal Constriction Response Caused By Intraperitoneal Inmentioning

confidence: 99%

Antinociceptive effects of Abarema cochliacarpos (B.A. Gomes) Barneby & J.W.Grimes (Mimosaceae)

Silva¹,

Esquibel²,

Alves³

et al. 2009

Rev. bras. farmacogn.

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RESUMO: "Efeito antinociceptivo de Abarema cochliacarpos (B.A. Gomes) Barneby & J.w.Grimes (Mimosaceae)". No presente trabalho foram avaliados a atividade antinociceptiva e o perfil fitoquímico dos extratos aquosos e metanólico produzidos com a casca do caule de Abarema cochliacarpos, uma espécie de Mata Atlântica com diversas indicações populares. Todos os extratos apresentaram atividade analgésica quando avaliados pelo teste das contorções abdominais induzidas pelo ácido acético via intraperitonial, apresentando respostas superiores às drogas usadas como referência, bem como no modelo da dor induzida por capsaicina. A avaliação fitoquímica demonstrou a presença de saponinas, catequinas, taninos, fenóis e antraquinonas.Unitermos: Abarema cochliacarpos, Mimosaceae, atividade analgésica, plantas medicinais, perfil fitoquímico. ABSTRACT:In this study, we investigated the analgesic activity of crude aqueous and methanol extracts obtained from Abarema cochliacarpos bark in mice, and analyzed its phytochemical profile. All the extracts exhibited analgesic properties against the writhing test in mice, but the aqueous and methanol extracts were more active, and more potent than two known analgesic and anti-inflammatory drugs used as reference. They were also active against the capsaicin-model, but inactive when evaluated in the hot-plate test. Phytochemical studies revealed the presence of saponins, catechins, tannins, phenols and anthraquinones.

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The Abdominal Constriction Response and Its Suppression by Analgesic Drugs in the Mouse

Cited by 1,043 publications

References 25 publications

Investigação das atividades analgésica e antiinflamatória do extrato metanólico dos rizomas de Echinodorus grandiflorus

Investigação das atividades analgésica e antiinflamatória do extrato metanólico dos rizomas de Echinodorus grandiflorus

An electronic pressure-meter nociception paw test for rats

Antinociceptive effects of Abarema cochliacarpos (B.A. Gomes) Barneby & J.W.Grimes (Mimosaceae)

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