The abietane diterpenoid parvifloron D from Plectranthus ecklonii is a potent apoptotic inducer in human leukemia cells

Burmistrova, Olga; Perdomo, Juan Alejandro; Simões, M. Fátima; Rijo, Patrícia; Quintana, José; Estévez, Francisco

doi:10.1016/j.phymed.2015.06.013

Cited by 36 publications

(48 citation statements)

References 21 publications

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“…Of these, the abietane diterpenes have demonstrated strong biological activity, particularly with regard to their cytotoxic, anti-proliferative and antimicrobial potential [17,32,33]. Therefore, in recent years, many molecular studies have examined their influence on various cancer cells [15,19].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Burmistrova et al report that Parv D displays cytotoxic activity against various leukemia cell lines, including HL-60, U-937, MOLT-3, and K-562 [6]. They propose that the mechanism of action is associated with a decrease in mitochondrial membrane potential and the release of cytochrome c, and that it may be amplified by inhibition of extracellular signal-regulated kinases (ERKs) 1/2 signaling; they also suggest it may be caused by a mechanism dependent on intracellular ROS generation in leukemia cells [19]. Santos-Rebelo et al also report that Parv D obtained from P. ecklonii displayed a cytotoxic effect on pancreatic cell lines [42].…”

Section: Discussionmentioning

confidence: 99%

“…Parviforon D (Parv D) was isolated from an acetonic extract Biomolecules 2020, 10,194 3 of 13 of the whole plant of P. ecklonii. The isolation and identification of all compounds were described earlier [15,19,21].…”

Section: Isolation and Identification Of Abietane Diterpenesmentioning

confidence: 99%

“…However, the acetone extracts are rich in various royleanones, including 7β,6β-dihydroxyroyleanone (Diroy) and 7α-acetoxy-6β-hydroxyroyleanone (Roy) [18]. Another Plectranthus member, P. ecklonii, is highly rich in another abietane diterpene, parvifloron D (Parv D), which has long been known to display potent anticancer activities [19,20].To gain a greater insight into their potential use in cancer treatment, the present study examines the apoptotic character of these Plectranthus-derived abietanes and their activities against a human glioma cell line.…”

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Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp.

et al. 2020

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Natural compounds isolated from plants are excellent starting points in drug design and have been widely studied as anticancer agents; they hence find use in a considerable proportion of anticancer drugs. The genus Plectranthus (Lamiaceae) comprises a large and widespread group of species with various applications in traditional medicine. Therefore, the aim of the present study was to determine the effectiveness of treatment with four abietane diterpenoids isolated from P. madagascariensis and P. ecklonii, 6,7-dehydroroyleanone, 7β,6β-dihydroxyroyleanone, 7α-acetoxy-6β-hydroxyroyleanone and parvifloron D, in initiating apoptosis in a glioma cell line. The pure compounds were found to exhibit anticancer effects in primary H7PX glioma cells line by inducing apoptosis G2/M cell cycle arrest and double-strand breaks, indicated by increased levels of phosphorylated H2A.X and decreasing mitochondrial membrane potential; they also influenced the expression of pro- and anti-apoptotic genes (Bax, Bcl-2, TP53, or Cas-3). Our findings indicate that these compounds may offer potential as beneficial antitumor drugs but further in vivo studies are needed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Isolation and Identification Of Abietane Diterpenesmentioning

confidence: 99%

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Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp.

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“…This genus is often cited for its medicinal properties and is traditionally used to treat gastro-intestinal, respiratory, infectious (such as malaria) or skin disorders (14). Several components of plants from the Plectranthus genus have been isolated and identified and have shown to have different pharmacological activities including antimicrobial (15), antitumor (16) and antioxidant activities (17). In the present work, the uric acid-lowering properties of an aqueous extract of Plectranthus saccatus plant, as well as of its major constituent, were studied.…”

Section: Introductionmentioning

confidence: 99%

Xanthine Oxidase Inhibitory Activity of a Plectranthus saccatus aqueous extract

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Rijo

et al. 2016

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Biopharmaceutical Sciences│Ciências BiofarmacêuticasBiomed Biopharm Res. , 2016; (13) 2: , 259-269 259 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Xanthine Oxidase Inhibitory Activity of a Plectranthus saccatus aqueous extract AbstractGout is a disease with high prevalence in developed countries, resulting from the deposition of uric acid crystals in various locations, particularly at the joints. The pharmacotherapeutic approach to chronic gout essentially consists of administration of uric acid-lowering agents. The main mechanism of action of these agents is the inhibition of xanthine oxidase (XO), the enzyme responsible for the formation of uric acid. The therapeutic alternatives available for this purpose are limited, thus justifying the interest of the discovery of potential new uric acidlowering drugs. In this regard, an aqueous extract of the plant Plectranthus saccatus has been studied for its ability to inhibit XO. The composition of the extract was determined by HPLC and rosmarinic acid was identified as the major constituent. Both the extract and rosmarinic acid have demonstrated the ability to inhibit the production of uric acid by interfering with XO activity. The results obtained herein support the continuation of the study of their uric acid-lowering properties in cell-based and in vivo models to further explore their potential in gout therapy. Key-words: Plectranthus saccatus, rosmarinic acid, xanthine oxidase, uric acid, gout ResumoA gota é uma patologia com elevada prevalência nos países desenvolvidos, que resulta da deposição de cristais de ácido úrico em várias localizações, sobretudo ao nível das articulações. A abordagem farmacoterapêutica da gota crónica consiste essencialmente na administração de agentes hipouricemiantes, i.e., fármacos que permitem reduzir os níveis séricos de ácido úrico. Estes agentes apresentam como principal mecanismo de ação a inibição da xantina oxidase (XO), a enzima responsável pela formação de ácido úrico. As alternativas terapêuticas disponíveis para este fim são limitadas, o que justifica o interesse da descoberta de potenciais novos fármacos hipouricemiantes. Neste âmbito, foi estudado um extrato aquoso da planta Plectranthus saccatus, relativamente à capacidade de inibição da XO. A composição do extrato foi determinada por HPLC, tendo-se identificado o ácido rosmarínico como constituinte maioritário. Tanto o extrato como o ácido rosmarínico demonstraram a capacidade de inibir a produção de ácido úrico por interferirem com a atividade da XO. Os resultados obtidos sustentam a continuação do estudo das suas propriedades hipouricemiantes em modelos celulares e in vivo, de modo a explorar mais aprofundadamente as suas potencialidades na terapêutica da gota. Palavras-chave:Plectranthus saccatus, ácido rosmarínico, xantina oxidase, ácido úrico, gota

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