The ability of hesperidin compared to that of insulin for preventing osteoporosis induced by type I diabetes in young male albino rats: A histological and biochemical study

Shehata, Azza S.; Amer, Mona G.; El-Haleem, Manal R. Abd; Karam, Rehab A.

doi:10.1016/j.etp.2017.01.008

Cited by 15 publications

(9 citation statements)

References 49 publications

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“…Until recently, to the knowledge of the researchers, herbal applications in the treatment of osteoporosis related to diabetes mellitus remain rare. An application of hesperidin to mice with type 1 diabetes mellitus can suppress some pro-inflammatory markers and increase serum markers of bone turnover, including osteopontin and osteocalcin, and lower alkaline phosphatase (10). Green tea supplementation has not been able to improve bone mineral content and bone mass in individuals with diabetes mellitus (11).…”

Section: Introductionmentioning

confidence: 99%

In Silico Interaction of the Active Compounds of Scurrula Atropurpurea with the RANK/RANKL/OPG System in Diabetoporosis

Akbar

Dewi²,

Setiawan

2019

Acta Inform Med

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Introduction: Diabetoporosis is a very complex health problem in Indonesia. One approach to the problem is through native Indonesian herbal medicine. The application of Scurrula atropurpurea in the treatment of diabetoporosis has not been revealed, so preliminary in silico study needs to be done. Aim: The purpose of the present study was to analyze the interaction between the active compound of Scurrula atropurpurea and the RANKL/RANK/OPG system in the pathomechanism of osteoporosis in diabetes mellitus. Methods: The procedures of the study included the search for the constituent amino acid of the RANK/RANKL/OPG system, the search for the structure of the active component of Scurrula atropurpurea , 3D modeling of protein structure, protein-ligand docking and visualization, and analysis of protein-ligand bonding interactions. Results: Those bond energies were RANKL-aviculin (–274.96 kJ/mol), RANKL-rutin (–263.12 kJ/mol), RANKL-quercitrin (–256.98 kJ/mol), RANKL-quercetin (–226,50 kJ/mol), RANKL-kaempferol (–221,65 kJ/mol), RANKL-catechin (–214,85 kJ/mol), RANKL-epicatechin (–211.66 kJ/mol), RANKL-caffeine (-171.73 kJ/mol), and RANKL-theobromine (-161.14 kJ/mol). The bond energies were RANK-rutin (-719.26 kJ/mol), RANK-catechin (-680.15 kJ/mol), RANK-caffeine (-654.48 kJ/mol), RANK-theobromine (-651.77 kJ/mol), RANK-quercitrin (-650.68 kJ/mol), RANK-kaempferol (-643.03 kJ/mol), RANK-epicatechin (-641.86 kJ/mol), RANK-quercetin (-641.76 kJ/mol), and RANK-aviculin (-628.62 kJ/mol). Those bond energies were OPG-epicatechin (-590.09 kJ/mol), OPG-theobromine (-578.08 kJ/mol), OPG-caffeine (-568.88 kJ/mol), RANKL-catechin (-560.63 kJ/mol), OPG-quercitrin (-554.50 kJ/mol), OPG-rutin (-547.91 kJ/mol), OPG-quercetin (-545.75 kJ/mol), OPG-kaempferol (-544.48 kJ/mol), and OPG-aviculin (-539.15 kJ/mol). Conclusion: The nine active ingredients of Scurrula atropurpurea do not interfere with the physiological function of RANKL to interact with RANK. The initial interaction of RANK with catechin or rutin will facilitate the bond of RANK to RANKL. When forming a complex with OPG, epicatechin will facilitate its interaction with RANKL.

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Section: Introductionmentioning

confidence: 99%

In Silico Interaction of the Active Compounds of Scurrula Atropurpurea with the RANK/RANKL/OPG System in Diabetoporosis

Akbar

Dewi²,

Setiawan

2019

Acta Inform Med

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“…Hesperidin has been shown to protect male mice against androgen deficiency-induced bone loss by inhibiting bone resorption and hyperlipidemia ( Chiba et al, 2014 ). It has been reported that hesperidin alleviated diabetic osteoporosis via reducing the expression level of TNF-α and NF-κB in rat bone and increasing the expression of OPN and OCN in serum ( Shehata et al, 2017 ). In addition, calcium supplementation along with hesperidin was effective to improve bone health in postmenopausal women ( Martin et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Hesperidin Ameliorates Dexamethasone-Induced Osteoporosis by Inhibiting p53

Zhang

Chen

Zeng

et al. 2022

Front. Cell Dev. Biol.

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Osteoporosis is one of the most frequent skeletal disorders and a major cause of morbidity and mortality in the expanding aging population. Evidence suggests that hesperidin may have a therapeutic impact on osteoporosis. Nevertheless, little is known about the role of hesperidin in the development of osteoporosis. Bioinformatics analyses were carried out to explore the functions and possible molecular mechanisms by which hesperidin regulates osteogenic differentiation. In the present study, we screened and harvested 12 KEGG pathways that were shared by hesperidin-targeted genes and osteoporosis. The p53 signaling pathway was considered to be a key mechanism. Our in vitro results showed that hesperidin partially reversed dexamethasone-induced inhibition of osteogenic differentiation by suppressing the activation of p53, and suggest that hesperidin may be a promising candidate for the treatment against dexamethasone-induced osteoporosis.

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“…Hesperidin which was used in this experiment is available in powder form and was dissolved in 1mL of 0.9% saline and given orally to group III at 200mg/kg/day using gastric gavage, 2 days after induction of diabetes for a period of 6 weeks. (15,16,18) Euthanasia of experimental animals Rats were euthanized after six weeks by decapitation. The mandible of each rat was dissected out and divided into 2 halves.…”

Section: Administration Of Hesperidinmentioning

confidence: 99%

Biological Effect of Hesperidin Administration on Alveolar Bone Structure in Induced Diabetic Rats

Aboshosha,

Elba,

Kawana

et al. 2023

Alexandria Dental Journal

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BACKGROUND: Diabetes mellitus (DM) is one of the most common endocrine disorders. It is associated with an elevation in blood glucose levels. Oxidative stress caused by hyperglycemia is central to the occurrence of diabetic complications such as retinopathy, nephropathy and diabetic osteopenia. Alveolar Bone forms the primary support structure of teeth. It's affected majorly by diabetic osteopenia. Some antidiabetic drugs may also increase the risk of diabetic fractures. Hesperidin is an active flavanone isolated from citrus fruits . OBJECTIVES: The aim of the current study is to evaluate the effect of Hesperidin administration on alveolar bone structure in rats with Streptozotocin-induced diabetes. MATERIALS AND METHODS: Eighteen adult male albino rats will be randomly divided into 3 equal groups: Group I (Control group). Group II (DM group): Rats will be administered Streptozotocin (STZ) to induce DM. Group III (Hesperidin group): Rats with STZ-induced DM will be given Hesperidin via gastric gavage. Rats will be euthanized after 6 weeks. Mandibles will be dissected and prepared for histological evaluation by light and scanning electron microscope. Percentages of Calcium and Phosphorus will be analyzed using EDX . RESULTS: Control group showed normal histological features of the alveolar bone. The diabetic group revealed an irregular outline with severe destruction while the Hesperidin group showed almost normal restoration of the structure of alveolar bone . CONCLUSION: Hesperidin exerted a protective effect on alveolar bone osteoporosis in diabetic rats .

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The ability of hesperidin compared to that of insulin for preventing osteoporosis induced by type I diabetes in young male albino rats: A histological and biochemical study

Cited by 15 publications

References 49 publications

In Silico Interaction of the Active Compounds of Scurrula Atropurpurea with the RANK/RANKL/OPG System in Diabetoporosis

In Silico Interaction of the Active Compounds of Scurrula Atropurpurea with the RANK/RANKL/OPG System in Diabetoporosis

Hesperidin Ameliorates Dexamethasone-Induced Osteoporosis by Inhibiting p53

Biological Effect of Hesperidin Administration on Alveolar Bone Structure in Induced Diabetic Rats

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