The ABO blood group system: historical background

Watkins, Winifred M.

doi:10.1046/j.1365-3148.2001.00321.x

Cited by 154 publications

(115 citation statements)

References 156 publications

(151 reference statements)

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“…Early studies on isolation and chemical characterization of ABH and Lewis antigens added much to the understanding of their structures (31,32). Technological advances allowed more detailed characterization and revealed the presence of type I-IV ABH structures attached to lipids and proteins in erythrocytes and tissues (3,5,7,(33)(34)(35)(36)(37)(38). Studies by us (data not shown) and others (39) recognized a problem in the stated specificity of many commercially available blood group antibodies.…”

Section: Discussionmentioning

confidence: 99%

Chemical Basis for Qualitative and Quantitative Differences Between ABO Blood Groups and Subgroups: Implications for Organ Transplantation

Jeyakanthan

Tao

Zou

et al. 2015

American Journal of Transplantation

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Blood group ABH(O) carbohydrate antigens are carried by precursor structures denoted type I-IV chains, creating unique antigen epitopes that may differ in expression between circulating erythrocytes and vascular endothelial cells. Characterization of such differences is invaluable in many clinical settings including transplantation. Monoclonal antibodies were generated and epitope specificities were characterized against chemically synthesized type I-IV ABH and related glycans. Antigen expression was detected on endomyocardial biopsies (n ¼ 50) and spleen (n ¼ 11) by immunohistochemical staining and on erythrocytes by flow cytometry. On vascular endothelial cells of heart and spleen, only type II-based ABH antigens were expressed; type III/IV structures were not detected. Type II-based ABH were expressed on erythrocytes of all blood groups. Group A 1 and A 2 erythrocytes additionally expressed type III/IV precursors, whereas group B and O erythrocytes did not. Intensity of A/B antigen expression differed among group A 1 , A 2 , A 1 B, A 2 B and B erythrocytes. On group A 2 erythrocytes, type III H structures were largely un-glycosylated with the terminal ''A'' sugar a-GalNAc. Together, these studies define qualitative and quantitative differences in ABH antigen expression between erythrocytes and vascular tissues. These expression profiles have important implications that must be considered in clinical settings of ABO-incompatible transplantation when interpreting anti-ABO antibodies measured by hemagglutination assays with reagent erythrocytes.

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Section: Discussionmentioning

confidence: 99%

Chemical Basis for Qualitative and Quantitative Differences Between ABO Blood Groups and Subgroups: Implications for Organ Transplantation

Jeyakanthan

Tao

Zou

et al. 2015

American Journal of Transplantation

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“…Namely, using our ELISA, we investigated its specificity for anti-A and anti-B Abs, measured anti-A and anti-B Abs in 6 ABO-I LDLT recipients, and evaluated its correlation with the agglutination titer. Landsteiner (1901), it is widely accepted that anti-A and anti-B Abs arise from immunization by exogenous factors in the environment, such as bacterial or viral antigens in the gastrointestinal tract (Watkins 2001;Hutson et al 2003). But the reason an individual's anti-A and anti-B Abs do not react with autologous blood type Ag remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Development of a Novel ELISA for Detection of Anti-A and Anti-B Antibodies in Recipients of ABO-Incompatible Living Donor Liver Grafts

Satoh

Kawagishi

Minegishi

et al. 2007

Tohoku J. Exp. Med.

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The survival rate in ABO-incompatible (ABO-I) liver transplantation was much lower than that in ABO-compatible recipients for the early experiences. It is therefore essential to develop the precise and fast measurement of anti-A and anti-B antibodies (Abs) to prevent humoral rejection in ABO-I liver transplantation. Agglutination titer has been the standard method to measure these Abs, but the interpretation of the results is subject to bias. Here, we have developed an objective and quantitative enzyme-linked immunosorbent assay (ELISA) to measure anti-A and anti-B Abs. This test requires only a small amount (10 μ l) of recipient's serum. We applied the newly developed ELISA to monitor living donor liver transplant recipients and investigated the correlation between ELISA and agglutination titer. The Spearman's correlation coefficient for Abs ranged from 0.461 to 0.812. Moreover, in one case of humoral rejection, the increase of Abs was detected by ELISA one day earlier than by the agglutination titer. In conclusion, our ELISA method proved useful to detect an increase of anti-A and anti-B Abs titers at an early stage, thereby contributing to a prompt treatment of humoral rejection due to ABO-I.ABO-incompatibility; ELISA; living donor liver transplantation; ABO histo-blood group antibodies; rejection

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“…ABO blood group system, initially described by Karl Landsteiner in 1900, is the most important blood group system in transfusion and organ transplantation medicine [1]. This system consists of four antigens-A, B AB and A1, and Four phenotypes-A, B, AB, and O blood groups.…”

Section: Introductionmentioning

confidence: 99%

Resolving Serological Blood Group Discrepancy and Providing Transfusion Support in a Patient of Mixed Auto Immune Hemolytic Anemia: A Case Report

Sahoo¹

2018

HIJ

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and presence of cold agglutinins. We report a case of mixed AIHA in 35 yr old lady who had severe anemia, blood group discrepancy, crossmatch incompatibility. We provided 2 units of Best matched blood (least incompatible) and she responded to corticosteroids. To our knowledge a careful communication between the transfusion services and clinicians can avoid unnecessary blood transfusions in such cases especially in clinically responding patients.

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The ABO blood group system: historical background

Cited by 154 publications

References 156 publications

Chemical Basis for Qualitative and Quantitative Differences Between ABO Blood Groups and Subgroups: Implications for Organ Transplantation

Chemical Basis for Qualitative and Quantitative Differences Between ABO Blood Groups and Subgroups: Implications for Organ Transplantation

Development of a Novel ELISA for Detection of Anti-A and Anti-B Antibodies in Recipients of ABO-Incompatible Living Donor Liver Grafts

Resolving Serological Blood Group Discrepancy and Providing Transfusion Support in a Patient of Mixed Auto Immune Hemolytic Anemia: A Case Report

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